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Tipranavir (PNU-140690): A Potent, Orally Bioavailable Nonpeptidic HIV Protease Inhibitor of the 5,6-Dihydro-4-hydroxy-2-pyrone Sulfonamide Class

Journal of medicinal chemistry, 1998-08, Vol.41 (18), p.3467-3476

1998

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Structure-Based Design of Novel HIV Protease Inhibitors: Sulfonamide-Containing 4-Hydroxycoumarins and 4-Hydroxy-2-pyrones as Potent Non-Peptidic Inhibitors

Journal of medicinal chemistry, 1996-06, Vol.39 (12), p.2400-2410

1996

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Structure-Based Design of Novel HIV Protease Inhibitors: Carboxamide-Containing 4-Hydroxycoumarins and 4-Hydroxy-2-pyrones as Potent Nonpeptidic Inhibitors

Journal of medicinal chemistry, 1995-09, Vol.38 (18), p.3624-3637

1995

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Synthesis and Biological Activities of (R)-5,6-Dihydro-N,N-dimethyl-4H-imidazo[4,5,1-ij]quinolin-5-amine and Its Metabolites

Journal of medicinal chemistry, 1997-02, Vol.40 (5), p.639-646

1997

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(-)-6-chloro-2-[(1-furo[2,3-c]pyridin-5-yl-ethyl)thio]-4-pyrimidinamine, PNU-142721, a new broad spectrum HIV-1 non-nucleoside reverse transcriptase inhibitor

Journal of medicinal chemistry, 1998-04, Vol.41 (9), p.1357-1360

1998

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Structure-Based Design of Sulfonamide-Substituted Non-Peptidic HIV Protease Inhibitors

Journal of medicinal chemistry, 1995-12, Vol.38 (26), p.4968-4971

1995

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The amphiphilic properties of novenamines determine their activity as inhibitors of HIV-1 RNase H

Cellular and molecular life sciences : CMLS, 1996-04, Vol.52 (4), p.329-335

1996

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Carbon–carbon-linked (pyrazolylphenyl)oxazolidinones with antibacterial activity against multiple drug resistant gram-positive and fastidious gram-negative bacteria

Bioorganic & medicinal chemistry, 2001-12, Vol.9 (12), p.3243-3253

2001

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Novenamine is the active moiety in novobiocin

Journal of antibiotics, 1986-02, Vol.39 (2), p.272-274

1986

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Identification of novel potent hydroxamic acid inhibitors of peptidyl deformylase and the importance of the hydroxamic acid functionality on inhibition

Bioorganic & medicinal chemistry letters, 2001-06, Vol.11 (11), p.1355-1358

2001

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CLAZAMYCIN B IS ANTIBIOTIC 354

The Journal of Antibiotics, 1980, Vol.33(1), pp.83-84

1980

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MICROBIAL HYDROXYLATION OF NOVOBIOCIN AND RELATED COMPOUNDS

The Journal of Antibiotics, 1984, Vol.37(2), pp.136-142

1984

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Asymmetric Syntheses and Absolute Stereochemistry of 5,6-Dihydro-α-pyrones, A New Class of Potent HIV Protease Inhibitors

Journal of the American Chemical Society, 1997-04, Vol.119 (15), p.3627-3628

1997

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3-TREHALOSAMINE, A NEW DISACCHARIDE ANTIBIOTIC

The Journal of Antibiotics, 1980, Vol.33(7), pp.690-694

1980

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Use of Medium-Sized Cycloalkyl Rings To Enhance Secondary Binding: Discovery of a New Class of Human Immunodeficiency Virus (HIV) Protease Inhibitors

Journal of medicinal chemistry, 1995-05, Vol.38 (11), p.1884-1891

1995

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THE SYNTHESIS OF NITROSOFUNGIN, A NEW ANTIBIOTIC

The Journal of Antibiotics, 1983, Vol.36(7), pp.916-917

1983

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NEW ANTIBIOTIC U-64846: FERMENTATION, ISOLATION AND CHARACTERIZATION

The Journal of Antibiotics, 1984, Vol.37(2), pp.96-102

1984

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ENZYMATIC PHOSPHORYLATION OF MACROLIDE ANTIBIOTICS

The Journal of Antibiotics, 1987/02/25, Vol.40(2), pp.195-201

1987

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FERMENTATION, ISOLATION, CHARACTERIZATION AND STRUCTURE OF NITROSOFUNGIN

The Journal of Antibiotics, 1983, Vol.36(11), pp.1425-1430

1983

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ISOLATION AND STRUCTURE OF ANTIBIOTIC U-68, 204, A NEW THIOLACTONE

The Journal of Antibiotics, 1986, Vol.39(1), pp.26-31

1986

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DESERTOMYCIN : PURIFICATION AND PHYSICAL-CHEMICAL PROPERTIES

The Journal of Antibiotics, 1983, Vol.36(1), pp.13-19

1983

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THE ISOLATION AND CHARACTERIZATION OF THE NEW ANTIBIOTIC U-60, 394

The Journal of Antibiotics, 1980, Vol.33(11), pp.1391-1394

1980

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Structure-Based Design of Nonpeptidic HIV Protease Inhibitors from a Cyclooctylpyranone Lead Structure

Journal of medicinal chemistry, 1995-10, Vol.38 (22), p.4463-4473

1995

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Identification of Phenylisoxazolines as Novel and Viable Antibacterial Agents Active against Gram-Positive Pathogens

Journal of medicinal chemistry, 2003-01, Vol.46 (2), p.284-302

2003

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Tipranavir (PNU-140690): A Potent, Orally Bioavailable Nonpeptidic HIV Protease Inhibitor of the 5,6-Dihydro-4-hydroxy-2-pyrone Sulfonamide Class

Structure-Based Design of Novel HIV Protease Inhibitors: Sulfonamide-Containing 4-Hydroxycoumarins and 4-Hydroxy-2-pyrones as Potent Non-Peptidic Inhibitors

Structure-Based Design of Novel HIV Protease Inhibitors: Carboxamide-Containing 4-Hydroxycoumarins and 4-Hydroxy-2-pyrones as Potent Nonpeptidic Inhibitors

Synthesis and Biological Activities of (R)-5,6-Dihydro-N,N-dimethyl-4H-imidazo[4,5,1-ij]quinolin-5-amine and Its Metabolites

(-)-6-chloro-2-[(1-furo[2,3-c]pyridin-5-yl-ethyl)thio]-4-pyrimidinamine, PNU-142721, a new broad spectrum HIV-1 non-nucleoside reverse transcriptase inhibitor

Structure-Based Design of Sulfonamide-Substituted Non-Peptidic HIV Protease Inhibitors

Structure-Based Design of Nonpeptidic HIV Protease Inhibitors: The Sulfonamide-Substituted Cyclooctylpyranones

The amphiphilic properties of novenamines determine their activity as inhibitors of HIV-1 RNase H

Carbon–carbon-linked (pyrazolylphenyl)oxazolidinones with antibacterial activity against multiple drug resistant gram-positive and fastidious gram-negative bacteria

Novenamine is the active moiety in novobiocin

Identification of novel potent hydroxamic acid inhibitors of peptidyl deformylase and the importance of the hydroxamic acid functionality on inhibition

CLAZAMYCIN B IS ANTIBIOTIC 354

MICROBIAL HYDROXYLATION OF NOVOBIOCIN AND RELATED COMPOUNDS

Asymmetric Syntheses and Absolute Stereochemistry of 5,6-Dihydro-α-pyrones, A New Class of Potent HIV Protease Inhibitors

3-TREHALOSAMINE, A NEW DISACCHARIDE ANTIBIOTIC

Use of Medium-Sized Cycloalkyl Rings To Enhance Secondary Binding: Discovery of a New Class of Human Immunodeficiency Virus (HIV) Protease Inhibitors

THE SYNTHESIS OF NITROSOFUNGIN, A NEW ANTIBIOTIC

NEW ANTIBIOTIC U-64846: FERMENTATION, ISOLATION AND CHARACTERIZATION

ENZYMATIC PHOSPHORYLATION OF MACROLIDE ANTIBIOTICS

FERMENTATION, ISOLATION, CHARACTERIZATION AND STRUCTURE OF NITROSOFUNGIN

ISOLATION AND STRUCTURE OF ANTIBIOTIC U-68, 204, A NEW THIOLACTONE

DESERTOMYCIN : PURIFICATION AND PHYSICAL-CHEMICAL PROPERTIES

THE ISOLATION AND CHARACTERIZATION OF THE NEW ANTIBIOTIC U-60, 394

Structure-Based Design of Nonpeptidic HIV Protease Inhibitors from a Cyclooctylpyranone Lead Structure

Identification of Phenylisoxazolines as Novel and Viable Antibacterial Agents Active against Gram-Positive Pathogens

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