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Individual and Combined Effects of Peroxisome Proliferator-Activated Receptor α and γ Agonists, Fenofibrate and Rosiglitazone, on Biomarkers of Lipid and Glucose Metabolism in Healthy Nondiabetic Volunteers

Journal of clinical pharmacology, 2005-05, Vol.45 (5), p.504-513

2005

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Low density lipoprotein is protected from oxidation and the progression of atherosclerosis is slowed in cholesterol-fed rabbits by the antioxidant N,N'-diphenyl-phenylenediamine

The Journal of clinical investigation, 1992-06, Vol.89 (6), p.1885-1891

1992

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Novel Peroxisome Proliferator-activated Receptor (PPAR) γ and PPARδ Ligands Produce Distinct Biological Effects

The Journal of biological chemistry, 1999-03, Vol.274 (10), p.6718-6725

1999

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Peroxisome proliferator-activated receptors gamma and alpha mediate in vivo regulation of uncoupling protein (UCP-1, UCP-2, UCP-3) gene expression

Endocrinology (Philadelphia), 1998-12, Vol.139 (12), p.4920-4927

1998

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Thiazolidinediones produce a conformational change in peroxisomal proliferator-activated receptor-gamma: binding and activation correlate with antidiabetic actions in db/db mice

Endocrinology (Philadelphia), 1996-10, Vol.137 (10), p.4189-4195

1996

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Discovery of a Novel Series of Peroxisome Proliferator-Activated Receptor α/γ Dual Agonists for the Treatment of Type 2 Diabetes and Dyslipidemia

Journal of medicinal chemistry, 2005-04, Vol.48 (7), p.2262-2265

2005

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Platelet activating factor (PAF) involvement in endotoxin-induced hypotension in rats. studies with paf-receptor antagonist kadsurenone

Biochemical and biophysical research communications, 1985-03, Vol.127 (3), p.799-808

1985

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Characterization of a Platelet-Activating Factor Receptor Antagonist Isolated from Haifenteng (Piper futokadsura): Specific Inhibition of in vitro and in vivo Platelet-Activating Factor-Induced Effects

Proceedings of the National Academy of Sciences - PNAS, 1985-02, Vol.82 (3), p.672-676

1985

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Down-regulation of the Expression of the Obese Gene by an Antidiabetic Thiazolidinedione in Zucker Diabetic Fatty Rats and db/db Mice (∗)

The Journal of biological chemistry, 1996-04, Vol.271 (16), p.9455-9459

1996

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MK-0767, a novel dual PPARα/γ agonist, displays robust antihyperglycemic and hypolipidemic activities

Biochemical and biophysical research communications, 2004-05, Vol.318 (2), p.323-328

2004

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Platelet-Activating Factor (PAF) Stimulates the PAF-Synthesizing Enzyme acetyl-CoA:1-alkyl-sn-glycero-3-phosphocholine O2-acetyltransferase and PAF Synthesis in Neutrophils

Proceedings of the National Academy of Sciences - PNAS, 1987-11, Vol.84 (21), p.7557-7561

1987

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Platelet-activating factor (PAF) mediation of rat anaphylactic responses to soluble immune complexes. Studies with PAF receptor antagonist L-652,731

The Journal of immunology (1950), 1986-06, Vol.136 (12), p.4659-4668

1986

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(±)-Trans-2-(3-methoxy-5-methylsulfonyl-4-propoxyphenyl)-5-(3,4,5-trimethoxyphenyl)tetrahydrofuran (L-659,989), a novel, potent PAF receptor antagonist

Biochemical and biophysical research communications, 1988-02, Vol.150 (3), p.1213-1220

1988

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Inhibition of the platelet activating factor (PAF)-induced in vivo responses in rats by trans-2,5-(3,4,5-trimethoxyphenyl) tetrahydrofuran (L-652,731), a PAF receptor antagonist

The Journal of pharmacology and experimental therapeutics, 1986-12, Vol.239 (3), p.841

1986

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Cell-specific ligands for selective drug delivery to tissues and organs

Journal of medicinal chemistry, 1981-12, Vol.24 (12), p.1388-1395

1981

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Enhanced macrophage uptake of synthetically glycosylated human placental beta-glucocerebrosidase

The Journal of biological chemistry, 1982-03, Vol.257 (5), p.2193-2199

1982

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Plasma clearance of glycoproteins with terminal mannose and N-acetylglucosamine by liver non-parenchymal cells. Studies with beta-glucuronidase, N-acetyl-beta-D-glucosaminidase, ribonuclease B and agalacto-orosomucoid

Biochemical journal, 1978-10, Vol.176 (1), p.103-109

1978

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Platelet‐activating factor (PAF) stimulates the lysoPAF acetyltransferase in leukocyte‐rich plasma: Use in PAF antagonist studies

Lipids, 1991-12, Vol.26 (12Part1), p.997-1003

1991

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Platelet activating factor intravenous infusion in rats stimulates vascular lysosomal hydrolase secretion independent of blood neutrophils

Biochemical and biophysical research communications, 1984-12, Vol.125 (3), p.980-987

1984

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Thiazolidinediones produce a conformational change in peroxisomal proliferator-activated receptor-gamma: binding and activation correlate with antidiabetic actions in db/db mice

Endocrinology (Philadelphia), 1996-10, Vol.137 (10), p.4189-4195

1996

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The role of extra-hepatic tissues in the receptor-mediated plasma clearance of glycoproteins terminated by mannose or N-acetylglucosamine

Biochemical journal, 1980-11, Vol.192 (2), p.597-606

1980

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Benzoyl 2-methyl indoles as selective PPARγ modulators

Bioorganic & medicinal chemistry letters, 2005-01, Vol.15 (2), p.357-362

2005

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Identification of a tripeptidyl aminopeptidase in the anterior pituitary gland: effect on the chemical and biological properties of rat and bovine growth hormones

Endocrinology (Philadelphia), 1978-11, Vol.103 (5), p.1794-1804

1978

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Gene expression profile of adipocyte differentiation and its regulation by peroxisome proliferator-activated receptor-gamma agonists

Endocrinology (Philadelphia), 2002-06, Vol.143 (6), p.2106-2118

2002

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Development, synthesis, and biological evaluation of (-)-trans-(2S,5S)-2-[3-[(2-oxopropyl)sulfonyl]-4-n-propoxy-5-(3-hydroxypropoxy)-phenyl]-5-(3,4,5-trimethoxyphenyl)tetrahydrofuran, a potent orally active platelet-activating factor (PAF) antagonist and its water-soluble prodrug phosphate ester

Journal of medicinal chemistry, 1992-09, Vol.35 (19), p.3474-3482

1992

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Individual and Combined Effects of Peroxisome Proliferator-Activated Receptor α and γ Agonists, Fenofibrate and Rosiglitazone, on Biomarkers of Lipid and Glucose Metabolism in Healthy Nondiabetic Volunteers

Low density lipoprotein is protected from oxidation and the progression of atherosclerosis is slowed in cholesterol-fed rabbits by the antioxidant N,N'-diphenyl-phenylenediamine

Novel Peroxisome Proliferator-activated Receptor (PPAR) γ and PPARδ Ligands Produce Distinct Biological Effects

Peroxisome proliferator-activated receptors gamma and alpha mediate in vivo regulation of uncoupling protein (UCP-1, UCP-2, UCP-3) gene expression

Thiazolidinediones produce a conformational change in peroxisomal proliferator-activated receptor-gamma: binding and activation correlate with antidiabetic actions in db/db mice

Discovery of a Novel Series of Peroxisome Proliferator-Activated Receptor α/γ Dual Agonists for the Treatment of Type 2 Diabetes and Dyslipidemia

Platelet activating factor (PAF) involvement in endotoxin-induced hypotension in rats. studies with paf-receptor antagonist kadsurenone

Characterization of a Platelet-Activating Factor Receptor Antagonist Isolated from Haifenteng (Piper futokadsura): Specific Inhibition of in vitro and in vivo Platelet-Activating Factor-Induced Effects

Down-regulation of the Expression of the Obese Gene by an Antidiabetic Thiazolidinedione in Zucker Diabetic Fatty Rats and db/db Mice (∗)

MK-0767, a novel dual PPARα/γ agonist, displays robust antihyperglycemic and hypolipidemic activities

Platelet-Activating Factor (PAF) Stimulates the PAF-Synthesizing Enzyme acetyl-CoA:1-alkyl-sn-glycero-3-phosphocholine O2-acetyltransferase and PAF Synthesis in Neutrophils

Platelet-activating factor (PAF) mediation of rat anaphylactic responses to soluble immune complexes. Studies with PAF receptor antagonist L-652,731

(±)-Trans-2-(3-methoxy-5-methylsulfonyl-4-propoxyphenyl)-5-(3,4,5-trimethoxyphenyl)tetrahydrofuran (L-659,989), a novel, potent PAF receptor antagonist

Inhibition of the platelet activating factor (PAF)-induced in vivo responses in rats by trans-2,5-(3,4,5-trimethoxyphenyl) tetrahydrofuran (L-652,731), a PAF receptor antagonist

Cell-specific ligands for selective drug delivery to tissues and organs

Enhanced macrophage uptake of synthetically glycosylated human placental beta-glucocerebrosidase

Plasma clearance of glycoproteins with terminal mannose and N-acetylglucosamine by liver non-parenchymal cells. Studies with beta-glucuronidase, N-acetyl-beta-D-glucosaminidase, ribonuclease B and agalacto-orosomucoid

Platelet‐activating factor (PAF) stimulates the lysoPAF acetyltransferase in leukocyte‐rich plasma: Use in PAF antagonist studies

Platelet activating factor intravenous infusion in rats stimulates vascular lysosomal hydrolase secretion independent of blood neutrophils

Thiazolidinediones produce a conformational change in peroxisomal proliferator-activated receptor-gamma: binding and activation correlate with antidiabetic actions in db/db mice

The role of extra-hepatic tissues in the receptor-mediated plasma clearance of glycoproteins terminated by mannose or N-acetylglucosamine

Benzoyl 2-methyl indoles as selective PPARγ modulators

Identification of a tripeptidyl aminopeptidase in the anterior pituitary gland: effect on the chemical and biological properties of rat and bovine growth hormones

Gene expression profile of adipocyte differentiation and its regulation by peroxisome proliferator-activated receptor-gamma agonists

Development, synthesis, and biological evaluation of (-)-trans-(2S,5S)-2-[3-[(2-oxopropyl)sulfonyl]-4-n-propoxy-5-(3-hydroxypropoxy)-phenyl]-5-(3,4,5-trimethoxyphenyl)tetrahydrofuran, a potent orally active platelet-activating factor (PAF) antagonist and its water-soluble prodrug phosphate ester

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