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Inhibition of thyroid hormone signaling protects retinal pigment epithelium and photoreceptors from cell death in a mouse model of age-related macular degeneration

Cell death & disease, 2020-01, Vol.11 (1), p.24, Article 24

2020

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Deficiency of thyroid hormone receptor protects retinal pigment epithelium and photoreceptors from cell death in a mouse model of age-related macular degeneration

Cell death & disease, 2022-03, Vol.13 (3), p.255-255, Article 255

2022

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Potential contribution of ryanodine receptor 2 upregulation to cGMP/PKG signaling‐induced cone degeneration in cyclic nucleotide‐gated channel deficiency

The FASEB journal, 2020-05, Vol.34 (5), p.6335-6350

2020

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Transcriptomic Analysis Reveals That Excessive Thyroid Hormone Signaling Impairs Phototransduction and Mitochondrial Bioenergetics and Induces Cellular Stress in Mouse Cone Photoreceptors

International journal of molecular sciences, 2024-07, Vol.25 (13), p.7435

2024

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Comparative mechanistic study of RPE cell death induced by different oxidative stresses

Redox biology, 2023-09, Vol.65, p.102840-102840, Article 102840

2023

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Inhibition of thyroid hormone receptor locally in the retina is a therapeutic strategy for retinal degeneration

The FASEB journal, 2017-08, Vol.31 (8), p.3425-3438

2017

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Suppressing thyroid hormone signaling preserves cone photoreceptors in mouse models of retinal degeneration

Proceedings of the National Academy of Sciences - PNAS, 2014-03, Vol.111 (9), p.3602-3607

2014

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cGMP accumulation causes photoreceptor degeneration in CNG channel deficiency: evidence of cGMP cytotoxicity independently of enhanced CNG channel function

The Journal of neuroscience, 2013-09, Vol.33 (37), p.14939-14948

2013

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Targeting iodothyronine deiodinases locally in the retina is a therapeutic strategy for retinal degeneration

The FASEB journal, 2016-12, Vol.30 (12), p.4313-4325

2016

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The cGMP-Dependent Protein Kinase 2 Contributes to Cone Photoreceptor Degeneration in the Cnga3 -Deficient Mouse Model of Achromatopsia

International journal of molecular sciences, 2020-12, Vol.22 (1), p.52

2020

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cGMP/Protein Kinase G Signaling Suppresses Inositol 1,4,5-Trisphosphate Receptor Phosphorylation and Promotes Endoplasmic Reticulum Stress in Photoreceptors of Cyclic Nucleotide-gated Channel-deficient Mice

The Journal of biological chemistry, 2015-08, Vol.290 (34), p.20880-20892

2015

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Endoplasmic Reticulum Stress-associated Cone Photoreceptor Degeneration in Cyclic Nucleotide-gated Channel Deficiency

The Journal of biological chemistry, 2012-05, Vol.287 (22), p.18018-18029

2012

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Ocular delivery of compacted DNA-nanoparticles does not elicit toxicity in the mouse retina

PloS one, 2009-10, Vol.4 (10), p.e7410-e7410

2009

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Expression of Cone-Photoreceptor-Specific Antigens in a Cell Line Derived from Retinal Tumors in Transgenic Mice

Investigative ophthalmology & visual science, 2004-03, Vol.45 (3), p.764-768

2004

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Early-onset, slow progression of cone photoreceptor dysfunction and degeneration in CNG channel subunit CNGB3 deficiency

Investigative ophthalmology & visual science, 2011-05, Vol.52 (6), p.3557-3566

2011

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Loss of cone cyclic nucleotide-gated channel leads to alterations in light response modulating system and cellular stress response pathways: a gene expression profiling study

Human molecular genetics, 2013-10, Vol.22 (19), p.3906-3919

2013

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Differential requirements for retinal degeneration slow intermolecular disulfide-linked oligomerization in rods versus cones

Human molecular genetics, 2009-03, Vol.18 (5), p.797-808

2009

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Preservation of endoplasmic reticulum (ER) Ca2+ stores by deletion of inositol‐1,4,5‐trisphosphate receptor type 1 promotes ER retrotranslocation, proteostasis, and protein outer segment localization in cyclic nucleotide‐gated channel‐deficient cone photoreceptors

The FASEB journal, 2021-06, Vol.35 (6), p.e21579-n/a

2021

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Thyroid Hormone Signaling in Retinal Development, Survival, and Disease

Vitamins and hormones, 2018, Vol.106, p.333-349

2018

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Inhibition of Ryanodine Receptor 1 Reduces Endoplasmic Reticulum (ER) Stress and Promotes ER Protein Degradation in Cyclic Nucleotide-Gated Channel Deficiency

Advances in experimental medicine and biology, 2023, Vol.1415, p.353-358

2023

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Promotion of endoplasmic reticulum retrotranslocation by overexpression of E3 ubiquitin‐protein ligase synoviolin 1 reduces endoplasmic reticulum stress and preserves cone photoreceptors in cyclic nucleotide‐gated channel deficiency

The FASEB journal, 2024-09, Vol.38 (17), p.e70021

2024

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Preservation of endoplasmic reticulum (ER) Ca 2+ stores by deletion of inositol-1,4,5-trisphosphate receptor type 1 promotes ER retrotranslocation, proteostasis, and protein outer segment localization in cyclic nucleotide-gated channel-deficient cone photoreceptors

The FASEB journal, 2021-06, Vol.35 (6), p.e21579

2021

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Deficiency of type 2 iodothyronine deiodinase reduces necroptosis activity and oxidative stress responses in retinas of Leber congenital amaurosis model mice

The FASEB journal, 2018-06, Vol.32 (11), p.fj201800484RR-fj201800484RR

2018

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Native cone photoreceptor cyclic nucleotide-gated channel is a heterotetrameric complex comprising both CNGA3 and CNGB3: a study using the cone-dominant retina of Nrl-/- mice

Journal of neurochemistry, 2008-09, Vol.106 (5), p.2042-2055

2008

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Thyroid Hormone Signaling and Cone Photoreceptor Viability

Advances in experimental medicine and biology, 2016-01, Vol.854, p.613-618

2016

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Inhibition of thyroid hormone signaling protects retinal pigment epithelium and photoreceptors from cell death in a mouse model of age-related macular degeneration

Deficiency of thyroid hormone receptor protects retinal pigment epithelium and photoreceptors from cell death in a mouse model of age-related macular degeneration

Potential contribution of ryanodine receptor 2 upregulation to cGMP/PKG signaling‐induced cone degeneration in cyclic nucleotide‐gated channel deficiency

Transcriptomic Analysis Reveals That Excessive Thyroid Hormone Signaling Impairs Phototransduction and Mitochondrial Bioenergetics and Induces Cellular Stress in Mouse Cone Photoreceptors

Comparative mechanistic study of RPE cell death induced by different oxidative stresses

Inhibition of thyroid hormone receptor locally in the retina is a therapeutic strategy for retinal degeneration

Suppressing thyroid hormone signaling preserves cone photoreceptors in mouse models of retinal degeneration

cGMP accumulation causes photoreceptor degeneration in CNG channel deficiency: evidence of cGMP cytotoxicity independently of enhanced CNG channel function

Targeting iodothyronine deiodinases locally in the retina is a therapeutic strategy for retinal degeneration

The cGMP-Dependent Protein Kinase 2 Contributes to Cone Photoreceptor Degeneration in the Cnga3 -Deficient Mouse Model of Achromatopsia

cGMP/Protein Kinase G Signaling Suppresses Inositol 1,4,5-Trisphosphate Receptor Phosphorylation and Promotes Endoplasmic Reticulum Stress in Photoreceptors of Cyclic Nucleotide-gated Channel-deficient Mice

Endoplasmic Reticulum Stress-associated Cone Photoreceptor Degeneration in Cyclic Nucleotide-gated Channel Deficiency

Ocular delivery of compacted DNA-nanoparticles does not elicit toxicity in the mouse retina

Expression of Cone-Photoreceptor-Specific Antigens in a Cell Line Derived from Retinal Tumors in Transgenic Mice

Early-onset, slow progression of cone photoreceptor dysfunction and degeneration in CNG channel subunit CNGB3 deficiency

Loss of cone cyclic nucleotide-gated channel leads to alterations in light response modulating system and cellular stress response pathways: a gene expression profiling study

Differential requirements for retinal degeneration slow intermolecular disulfide-linked oligomerization in rods versus cones

Preservation of endoplasmic reticulum (ER) Ca2+ stores by deletion of inositol‐1,4,5‐trisphosphate receptor type 1 promotes ER retrotranslocation, proteostasis, and protein outer segment localization in cyclic nucleotide‐gated channel‐deficient cone photoreceptors

Thyroid Hormone Signaling in Retinal Development, Survival, and Disease

Inhibition of Ryanodine Receptor 1 Reduces Endoplasmic Reticulum (ER) Stress and Promotes ER Protein Degradation in Cyclic Nucleotide-Gated Channel Deficiency

Promotion of endoplasmic reticulum retrotranslocation by overexpression of E3 ubiquitin‐protein ligase synoviolin 1 reduces endoplasmic reticulum stress and preserves cone photoreceptors in cyclic nucleotide‐gated channel deficiency

Preservation of endoplasmic reticulum (ER) Ca 2+ stores by deletion of inositol-1,4,5-trisphosphate receptor type 1 promotes ER retrotranslocation, proteostasis, and protein outer segment localization in cyclic nucleotide-gated channel-deficient cone photoreceptors

Deficiency of type 2 iodothyronine deiodinase reduces necroptosis activity and oxidative stress responses in retinas of Leber congenital amaurosis model mice

Native cone photoreceptor cyclic nucleotide-gated channel is a heterotetrameric complex comprising both CNGA3 and CNGB3: a study using the cone-dominant retina of Nrl-/- mice

Thyroid Hormone Signaling and Cone Photoreceptor Viability

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