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Selection of a Moxifloxacin Dose That Suppresses Drug Resistance in Mycobacterium tuberculosis, by Use of an In Vitro Pharmacodynamic Infection Model and Mathematical Modeling

The Journal of infectious diseases, 2004-11, Vol.190 (9), p.1642-1651

2004

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Concentration-Dependent Mycobacterium tuberculosis Killing and Prevention of Resistance by Rifampin

Antimicrobial Agents and Chemotherapy, 2007-11, Vol.51 (11), p.3781-3788

2007

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The Relationship between Quinolone Exposures and Resistance Amplification Is Characterized by an Inverted U: a New Paradigm for Optimizing Pharmacodynamics To Counterselect Resistance

Antimicrobial Agents and Chemotherapy, 2007-02, Vol.51 (2), p.744-747

2007

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Bacterial-Population Responses to Drug-Selective Pressure: Examination of Garenoxacin’s Effect on Pseudomonas aeruginosa

The Journal of infectious diseases, 2005-08, Vol.192 (3), p.420-428

2005

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Pharmacodynamic Evidence that Ciprofloxacin Failure against Tuberculosis Is Not Due to Poor Microbial Kill but to Rapid Emergence of Resistance

Antimicrobial Agents and Chemotherapy, 2005-08, Vol.49 (8), p.3178-3181

2005

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Anidulafungin Pharmacokinetics and Microbial Response in Neutropenic Mice with Disseminated Candidiasis

Antimicrobial Agents and Chemotherapy, 2006-11, Vol.50 (11), p.3695-3700

2006

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Application of a mathematical model to prevent in vivo amplification of antibiotic-resistant bacterial populations during therapy

The Journal of clinical investigation, 2003-07, Vol.112 (2), p.275-285

2003

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Effective Antimicrobial Regimens for Use in Humans for Therapy of Bacillus anthracis Infections and Postexposure Prophylaxis

Antimicrobial Agents and Chemotherapy, 2005-12, Vol.49 (12), p.5099-5106

2005

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Quinolone Efflux Pumps Play a Central Role in Emergence of Fluoroquinolone Resistance in Streptococcus pneumoniae

Antimicrobial Agents and Chemotherapy, 2006-01, Vol.50 (1), p.310-317

2006

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Impact of Resistance Selection and Mutant Growth Fitness on the Relative Efficacies of Streptomycin and Levofloxacin for Plague Therapy

Antimicrobial Agents and Chemotherapy, 2007-08, Vol.51 (8), p.2661-2667

2007

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Pharmacodynamics of Cidofovir for Vaccinia Virus Infection in an In Vitro Hollow-Fiber Infection Model System

Antimicrobial Agents and Chemotherapy, 2009-01, Vol.53 (1), p.129-135

2009

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In Vitro Infection Model Characterizing the Effect of Efflux Pump Inhibition on Prevention of Resistance to Levofloxacin and Ciprofloxacin in Streptococcus pneumoniae

Antimicrobial Agents and Chemotherapy, 2007-11, Vol.51 (11), p.3988-4000

2007

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Quinolone efflux pumps play a central role in emergence of fluoroquinolone resistance in Streptococcus pneumoniae

Antimicrobial agents and chemotherapy, 2006, Vol.50 (1), p.310-317

2006

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Discovery of a New Class of Macrocyclic Antagonists to the Human Motilin Receptor

Journal of medicinal chemistry, 2006-11, Vol.49 (24), p.7190-7197

2006

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Retinoic acid inhibition of thyroxine binding to human transthyretin

Biochimica et biophysica acta, 1994-01, Vol.1199 (1), p.76-80

1994

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Inhibition of human cytomegalovirus protease N o with monocyclic β-lactams

Bioorganic & medicinal chemistry letters, 1998-06, Vol.8 (11), p.1437-1442

1998

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Purification of a high molecular weight follicle-stimulating hormone receptor-binding inhibitor from human follicular fluid

The journal of clinical endocrinology and metabolism, 1993-07, Vol.77 (1), p.163-168

1993

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Synthetic peptides corresponding to residues 551 to 555 and 650 to 653 of the rat testicular follicle-stimulating hormone (FSH) receptor are sufficient for post-receptor modulation of Sertoli cell responsiveness to FSH stimulation

Regulatory peptides, 1995-12, Vol.60 (2), p.177-183

1995

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Myofibrillar protein structure and assembly during idiopathic dilated cardiomyopathy

Molecular and cellular biochemistry, 1999-05, Vol.195 (1-2), p.1-10

1999

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Synthesis and antiviral activity of monobactams inhibiting the human cytomegalovirus protease

Bioorganic & medicinal chemistry, 1999-08, Vol.7 (8), p.1521-1531

1999

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Novel nevirapine-like inhibitors with improved activity against NNRTI-resistant HIV: 8-heteroarylthiomethyldipyridodiazepinone derivatives

Bioorganic & medicinal chemistry letters, 2004-02, Vol.14 (3), p.739-742

2004

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β-Lactam Derivatives as Inhibitors of Human Cytomegalovirus Protease

Journal of medicinal chemistry, 1998-07, Vol.41 (15), p.2882-2891

1998

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Inhibition of human cytomegalovirus protease N(o) with monocyclic beta-lactams

Bioorganic & medicinal chemistry letters, 1998-06, Vol.8 (11), p.1437-1442

1998

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A potent peptidomimetic inhibitor of HSV ribonucleotide reductase with antiviral activity in vivo

Nature (London), 1994-12, Vol.372 (6507), p.695-698

1994

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Increased plasma IGF-1 levels but lack of changes in adipocyte glucose transport in weanling rats with dorsomedial hypothalamic nucleus lesions 1 year after lesion production

Physiology & behavior, 1996-04, Vol.59 (4), p.689-697

1996

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Selection of a Moxifloxacin Dose That Suppresses Drug Resistance in Mycobacterium tuberculosis, by Use of an In Vitro Pharmacodynamic Infection Model and Mathematical Modeling

Concentration-Dependent Mycobacterium tuberculosis Killing and Prevention of Resistance by Rifampin

The Relationship between Quinolone Exposures and Resistance Amplification Is Characterized by an Inverted U: a New Paradigm for Optimizing Pharmacodynamics To Counterselect Resistance

Bacterial-Population Responses to Drug-Selective Pressure: Examination of Garenoxacin’s Effect on Pseudomonas aeruginosa

Pharmacodynamic Evidence that Ciprofloxacin Failure against Tuberculosis Is Not Due to Poor Microbial Kill but to Rapid Emergence of Resistance

Anidulafungin Pharmacokinetics and Microbial Response in Neutropenic Mice with Disseminated Candidiasis

Application of a mathematical model to prevent in vivo amplification of antibiotic-resistant bacterial populations during therapy

Effective Antimicrobial Regimens for Use in Humans for Therapy of Bacillus anthracis Infections and Postexposure Prophylaxis

Quinolone Efflux Pumps Play a Central Role in Emergence of Fluoroquinolone Resistance in Streptococcus pneumoniae

Impact of Resistance Selection and Mutant Growth Fitness on the Relative Efficacies of Streptomycin and Levofloxacin for Plague Therapy

Pharmacodynamics of Cidofovir for Vaccinia Virus Infection in an In Vitro Hollow-Fiber Infection Model System

In Vitro Infection Model Characterizing the Effect of Efflux Pump Inhibition on Prevention of Resistance to Levofloxacin and Ciprofloxacin in Streptococcus pneumoniae

Quinolone efflux pumps play a central role in emergence of fluoroquinolone resistance in Streptococcus pneumoniae

Discovery of a New Class of Macrocyclic Antagonists to the Human Motilin Receptor

Retinoic acid inhibition of thyroxine binding to human transthyretin

Inhibition of human cytomegalovirus protease N o with monocyclic β-lactams

Purification of a high molecular weight follicle-stimulating hormone receptor-binding inhibitor from human follicular fluid

Synthetic peptides corresponding to residues 551 to 555 and 650 to 653 of the rat testicular follicle-stimulating hormone (FSH) receptor are sufficient for post-receptor modulation of Sertoli cell responsiveness to FSH stimulation

Myofibrillar protein structure and assembly during idiopathic dilated cardiomyopathy

Synthesis and antiviral activity of monobactams inhibiting the human cytomegalovirus protease

Novel nevirapine-like inhibitors with improved activity against NNRTI-resistant HIV: 8-heteroarylthiomethyldipyridodiazepinone derivatives

β-Lactam Derivatives as Inhibitors of Human Cytomegalovirus Protease

Inhibition of human cytomegalovirus protease N(o) with monocyclic beta-lactams

A potent peptidomimetic inhibitor of HSV ribonucleotide reductase with antiviral activity in vivo

Increased plasma IGF-1 levels but lack of changes in adipocyte glucose transport in weanling rats with dorsomedial hypothalamic nucleus lesions 1 year after lesion production

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