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IAP family proteins--suppressors of apoptosis

Genes & development, 1999-02, Vol.13 (3), p.239-252

1999

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IAPs block apoptotic events induced by caspase-8 and cytochrome c by direct inhibition of distinct caspases

The EMBO journal, 1998-04, Vol.17 (8), p.2215-2223

1998

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X-linked IAP is a direct inhibitor of cell-death proteases

Nature (London), 1997-07, Vol.388 (6639), p.300-304

1997

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Cleavage of human inhibitor of apoptosis protein XIAP results in fragments with distinct specificities for caspases

The EMBO journal, 1999-10, Vol.18 (19), p.5242-5251

1999

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Caspase-3 is essential for procaspase-9 processing and cisplatin-induced apoptosis of MCF-7 breast cancer cells

Cancer research (Chicago, Ill.), 2000-08, Vol.60 (16), p.4386-4390

2000

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Endogenous inhibitors of caspases

Journal of clinical immunology, 1999-11, Vol.19 (6), p.388-398

1999

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Changes in intramitochondrial and cytosolic pH: early events that modulate caspase activation during apoptosis

Nature cell biology, 2000-06, Vol.2 (6), p.318-325

2000

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Synthetic lethal targeting of MYC by activation of the DR5 death receptor pathway

Cancer cell, 2004-05, Vol.5 (5), p.501-512

2004

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Overexpression, genomic amplification and therapeutic potential of inhibiting the UbcH10 ubiquitin conjugase in human carcinomas of diverse anatomic origin

Oncogene, 2004-08, Vol.23 (39), p.6621-6629

2004

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The c-IAP-1 and c-IAP-2 proteins are direct inhibitors of specific caspases

The EMBO journal, 1997-12, Vol.16 (23), p.6914-6925

1997

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Release of Caspase-9 from Mitochondria during Neuronal Apoptosis and Cerebral Ischemia

Proceedings of the National Academy of Sciences - PNAS, 1999-05, Vol.96 (10), p.5752-5757

1999

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Caspase-9 Can Be Activated without Proteolytic Processing

The Journal of biological chemistry, 1999-03, Vol.274 (13), p.8359-8362

1999

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RNAi and HTS: exploring cancer by systematic loss-of-function

Oncogene, 2004-11, Vol.23 (51), p.8392-8400

2004

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Evolutionary Conservation of Apoptosis Mechanisms: Lepidopteran and Baculoviral Inhibitor of Apoptosis Proteins Are Inhibitors of Mammalian Caspase-9

Proceedings of the National Academy of Sciences - PNAS, 2000-02, Vol.97 (4), p.1427-1432

2000

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Antiapoptotic proteins. The bcl-2 and inhibitor of apoptosis protein families

Cardiology clinics, 2001-02, Vol.19 (1), p.57-74

2001

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TRAF1 Is a Substrate of Caspases Activated during Tumor Necrosis Factor Receptor-α-induced Apoptosis

The Journal of biological chemistry, 2001-03, Vol.276 (11), p.8087-8093

2001

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Cloning and characterization of an inhibitor of apoptosis protein (IAP) from Bombyx mori

Biochimica et biophysica acta, 2001-01, Vol.1499 (3), p.191-198

2001

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Identification of Modulators of TRAIL-Induced Apoptosis via RNAi-Based Phenotypic Screening

Molecular cell, 2003-09, Vol.12 (3), p.627-637

2003

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Exposing oncogenic dependencies for cancer drug target discovery and validation using RNAi

Seminars in cancer biology, 2003-08, Vol.13 (4), p.293-300

2003

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Caspase-2 Can Function Upstream of Bid Cleavage in the TRAIL Apoptosis Pathway

The Journal of biological chemistry, 2004-08, Vol.279 (33), p.35047-35052

2004

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A TRAIL Receptor-Dependent Synthetic Lethal Relationship between MYC Activation and GSK3β/FBW7 Loss of Function

Proceedings of the National Academy of Sciences - PNAS, 2005-10, Vol.102 (42), p.15195-15200

2005

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[13] Purification and use of recombinant inhibitor of apoptosis proteins as caspase inhibitors

Methods in Enzymology, 2000, Vol.322, p.154-161

2000

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IAP Suppression of Apoptosis Involves Distinct Mechanisms: the TAK1/JNK1 Signaling Cascade and Caspase Inhibition

Molecular and Cellular Biology, 2002-03, Vol.22 (6), p.1754-1766

2002

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Differential regulation of the TRAIL death receptors DR4 and DR5 by the signal recognition particle

Molecular biology of the cell, 2004-11, Vol.15 (11), p.5064-5074

2004

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ILPIP, a Novel Anti-apoptotic Protein That Enhances XIAP-mediated Activation of JNK1 and Protection against Apoptosis

The Journal of biological chemistry, 2002-08, Vol.277 (34), p.30454-30462

2002

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Cell Death
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IAP family proteins--suppressors of apoptosis

IAPs block apoptotic events induced by caspase-8 and cytochrome c by direct inhibition of distinct caspases

X-linked IAP is a direct inhibitor of cell-death proteases

Cleavage of human inhibitor of apoptosis protein XIAP results in fragments with distinct specificities for caspases

Caspase-3 is essential for procaspase-9 processing and cisplatin-induced apoptosis of MCF-7 breast cancer cells

Endogenous inhibitors of caspases

Changes in intramitochondrial and cytosolic pH: early events that modulate caspase activation during apoptosis

Synthetic lethal targeting of MYC by activation of the DR5 death receptor pathway

Overexpression, genomic amplification and therapeutic potential of inhibiting the UbcH10 ubiquitin conjugase in human carcinomas of diverse anatomic origin

The c-IAP-1 and c-IAP-2 proteins are direct inhibitors of specific caspases

Release of Caspase-9 from Mitochondria during Neuronal Apoptosis and Cerebral Ischemia

Caspase-9 Can Be Activated without Proteolytic Processing

RNAi and HTS: exploring cancer by systematic loss-of-function

Evolutionary Conservation of Apoptosis Mechanisms: Lepidopteran and Baculoviral Inhibitor of Apoptosis Proteins Are Inhibitors of Mammalian Caspase-9

Antiapoptotic proteins. The bcl-2 and inhibitor of apoptosis protein families

TRAF1 Is a Substrate of Caspases Activated during Tumor Necrosis Factor Receptor-α-induced Apoptosis

Cloning and characterization of an inhibitor of apoptosis protein (IAP) from Bombyx mori

Identification of Modulators of TRAIL-Induced Apoptosis via RNAi-Based Phenotypic Screening

Exposing oncogenic dependencies for cancer drug target discovery and validation using RNAi

Caspase-2 Can Function Upstream of Bid Cleavage in the TRAIL Apoptosis Pathway

A TRAIL Receptor-Dependent Synthetic Lethal Relationship between MYC Activation and GSK3β/FBW7 Loss of Function

[13] Purification and use of recombinant inhibitor of apoptosis proteins as caspase inhibitors

IAP Suppression of Apoptosis Involves Distinct Mechanisms: the TAK1/JNK1 Signaling Cascade and Caspase Inhibition

Differential regulation of the TRAIL death receptors DR4 and DR5 by the signal recognition particle

ILPIP, a Novel Anti-apoptotic Protein That Enhances XIAP-mediated Activation of JNK1 and Protection against Apoptosis

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