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ADAM Proteases and Gastrointestinal Function

Annual review of physiology, 2016-02, Vol.78 (1), p.243-276

2016

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Notch signaling modulates proliferation and differentiation of intestinal crypt base columnar stem cells

Development (Cambridge), 2012-02, Vol.139 (3), p.488-497

2012

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ADAMs as mediators of EGF receptor transactivation by G protein-coupled receptors

American Journal of Physiology: Cell Physiology, 2006-07, Vol.291 (1), p.C1-C10

2006

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Transcriptome-wide Analysis Reveals Hallmarks of Human Intestine Development and Maturation In Vitro and In Vivo

Stem cell reports, 2015-06, Vol.4 (6), p.1140-1155

2015

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Examination of Wnt signaling as a therapeutic target for pancreatic ductal adenocarcinoma (PDAC) using a pancreatic tumor organoid library (PTOL)

PloS one, 2024-04, Vol.19 (4), p.e0298808-e0298808

2024

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ErbB4 signaling stimulates pro-inflammatory macrophage apoptosis and limits colonic inflammation

Cell death & disease, 2017-02, Vol.8 (2), p.e2622-e2622

2017

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Robo4 is constitutively shed by ADAMs from endothelial cells and the shed Robo4 functions to inhibit Slit3-induced angiogenesis

Scientific reports, 2022-03, Vol.12 (1), p.4352-4352, Article 4352

2022

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Pharmacogenomic Predictor of Sensitivity to Preoperative Chemotherapy With Paclitaxel and Fluorouracil, Doxorubicin, and Cyclophosphamide in Breast Cancer

Journal of clinical oncology, 2006-09, Vol.24 (26), p.4236-4244

2006

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ADAM10 is essential for Notch2-dependent marginal zone B cell development and CD23 cleavage in vivo

The Journal of experimental medicine, 2010-03, Vol.207 (3), p.623-635

2010

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TPN‐associated intestinal epithelial cell atrophy is modulated by TLR4/EGF signaling pathways

The FASEB journal, 2015-07, Vol.29 (7), p.2943-2958

2015

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Role of ADAM10 in intestinal crypt homeostasis and tumorigenesis

Biochimica et biophysica acta. Molecular cell research, 2017-11, Vol.1864 (11), p.2228-2239

Dempsey, Peter J.

2017

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Constitutive α- and β-secretase cleavages of the amyloid precursor protein are partially coupled in neurons, but not in frequently used cell lines

Neurobiology of disease, 2013-01, Vol.49, p.137-147

2013

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Mucus Detachment by Host Metalloprotease Meprin β Requires Shedding of Its Inactive Pro-form, which Is Abrogated by the Pathogenic Protease RgpB

Cell reports (Cambridge), 2017-11, Vol.21 (8), p.2090-2103

2017

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A Disintegrin and Metalloproteinase 10-Mediated Cleavage and Shedding Regulates the Cell Surface Expression of CXC Chemokine Ligand 16

The Journal of immunology (1950), 2004-03, Vol.172 (6), p.3678-3685

2004

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Loss of ADAM17-Mediated Tumor Necrosis Factor Alpha Signaling in Intestinal Cells Attenuates Mucosal Atrophy in a Mouse Model of Parenteral Nutrition

Molecular and cellular biology, 2015-11, Vol.35 (21), p.3604-3621

2015

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Generation of novel, secreted epidermal growth factor receptor (EGFR/ErbB1) isoforms via metalloprotease-dependent ectodomain shedding and exosome secretion

Journal of cellular biochemistry, 2008-04, Vol.103 (6), p.1783-1797

2008

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Epidermal Growth Factor Receptor Activation Protects Gastric Epithelial Cells From Helicobacter pylori -Induced Apoptosis

Gastroenterology (New York, N.Y. 1943), 2009-04, Vol.136 (4), p.1297-1307.e3

2009

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TACE/ADAM-17: A Component of the Epidermal Growth Factor Receptor Axis and a Promising Therapeutic Target in Colorectal Cancer

Clinical cancer research, 2008-02, Vol.14 (4), p.1182-1191

2008

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G Protein Coupling and Second Messenger Generation Are Indispensable for Metalloprotease-dependent, Heparin-binding Epidermal Growth Factor Shedding through Angiotensin II Type-1 Receptor

The Journal of biological chemistry, 2005-07, Vol.280 (28), p.26592-26599

2005

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Control of ErbB signaling through metalloprotease mediated ectodomain shedding of EGF-like factors

Growth factors (Chur, Switzerland), 2006, Vol.24 (2), p.121-136

2006

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Interdependency of EGF and GLP-2 Signaling in Attenuating Mucosal Atrophy in a Mouse Model of Parenteral Nutrition

Cellular and molecular gastroenterology and hepatology, 2017-05, Vol.3 (3), p.447-468

2017

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ADAM10 Mediates Ectodomain Shedding of the Betacellulin Precursor Activated by p-Aminophenylmercuric Acetate and Extracellular Calcium Influx

The Journal of biological chemistry, 2005-01, Vol.280 (3), p.1826-1837

2005

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The Effect of Thiol Structure on Allyl Sulfide Photodegradable Hydrogels and their Application as a Degradable Scaffold for Organoid Passaging

Advanced materials (Weinheim), 2020-07, Vol.32 (30), p.e1905366-n/a

2020

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Are Facultative Reserve ISCs the Cellular Origin of Familial Small Intestinal Neuroendocrine Tumors?

Gastroenterology (New York, N.Y. 1943), 2016-07, Vol.151 (1), p.27-29

Dempsey, Peter

2016

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A Lactobacillus rhamnosus GG-derived Soluble Protein, p40, Stimulates Ligand Release from Intestinal Epithelial Cells to Transactivate Epidermal Growth Factor Receptor

The Journal of biological chemistry, 2013-10, Vol.288 (42), p.30742-30751

2013

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ADAM Proteases and Gastrointestinal Function

Notch signaling modulates proliferation and differentiation of intestinal crypt base columnar stem cells

ADAMs as mediators of EGF receptor transactivation by G protein-coupled receptors

Transcriptome-wide Analysis Reveals Hallmarks of Human Intestine Development and Maturation In Vitro and In Vivo

Examination of Wnt signaling as a therapeutic target for pancreatic ductal adenocarcinoma (PDAC) using a pancreatic tumor organoid library (PTOL)

ErbB4 signaling stimulates pro-inflammatory macrophage apoptosis and limits colonic inflammation

Robo4 is constitutively shed by ADAMs from endothelial cells and the shed Robo4 functions to inhibit Slit3-induced angiogenesis

Pharmacogenomic Predictor of Sensitivity to Preoperative Chemotherapy With Paclitaxel and Fluorouracil, Doxorubicin, and Cyclophosphamide in Breast Cancer

ADAM10 is essential for Notch2-dependent marginal zone B cell development and CD23 cleavage in vivo

TPN‐associated intestinal epithelial cell atrophy is modulated by TLR4/EGF signaling pathways

Role of ADAM10 in intestinal crypt homeostasis and tumorigenesis

Constitutive α- and β-secretase cleavages of the amyloid precursor protein are partially coupled in neurons, but not in frequently used cell lines

Mucus Detachment by Host Metalloprotease Meprin β Requires Shedding of Its Inactive Pro-form, which Is Abrogated by the Pathogenic Protease RgpB

A Disintegrin and Metalloproteinase 10-Mediated Cleavage and Shedding Regulates the Cell Surface Expression of CXC Chemokine Ligand 16

Loss of ADAM17-Mediated Tumor Necrosis Factor Alpha Signaling in Intestinal Cells Attenuates Mucosal Atrophy in a Mouse Model of Parenteral Nutrition

Generation of novel, secreted epidermal growth factor receptor (EGFR/ErbB1) isoforms via metalloprotease-dependent ectodomain shedding and exosome secretion

Epidermal Growth Factor Receptor Activation Protects Gastric Epithelial Cells From Helicobacter pylori -Induced Apoptosis

TACE/ADAM-17: A Component of the Epidermal Growth Factor Receptor Axis and a Promising Therapeutic Target in Colorectal Cancer

G Protein Coupling and Second Messenger Generation Are Indispensable for Metalloprotease-dependent, Heparin-binding Epidermal Growth Factor Shedding through Angiotensin II Type-1 Receptor

Control of ErbB signaling through metalloprotease mediated ectodomain shedding of EGF-like factors

Interdependency of EGF and GLP-2 Signaling in Attenuating Mucosal Atrophy in a Mouse Model of Parenteral Nutrition

ADAM10 Mediates Ectodomain Shedding of the Betacellulin Precursor Activated by p-Aminophenylmercuric Acetate and Extracellular Calcium Influx

The Effect of Thiol Structure on Allyl Sulfide Photodegradable Hydrogels and their Application as a Degradable Scaffold for Organoid Passaging

Are Facultative Reserve ISCs the Cellular Origin of Familial Small Intestinal Neuroendocrine Tumors?

A Lactobacillus rhamnosus GG-derived Soluble Protein, p40, Stimulates Ligand Release from Intestinal Epithelial Cells to Transactivate Epidermal Growth Factor Receptor

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