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Discovery of Disubstituted Cyclohexanes as a New Class of CC Chemokine Receptor 2 Antagonists

Journal of medicinal chemistry, 2008-02, Vol.51 (4), p.721-724

2008

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α,β-Cyclic-β-benzamido hydroxamic acids: Novel templates for the design, synthesis, and evaluation of selective inhibitors of TNF-α converting enzyme (TACE)

Bioorganic & medicinal chemistry, 2008-01, Vol.18 (2), p.694-699

2008

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N-in-1 Dosing Pharmacokinetics in Drug Discovery: Experience, Theoretical and Practical Considerations

Journal of pharmaceutical sciences, 2008-07, Vol.97 (7), p.2568-2580

2008

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Discovery of trisubstituted cyclohexanes as potent CC chemokine receptor 2 (CCR2) antagonists

Bioorganic & medicinal chemistry letters, 2009-02, Vol.19 (3), p.597-601

2009

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Synthesis and evaluation of cis-3,4-disubstituted piperidines as potent CC chemokine receptor 2 (CCR2) antagonists

Bioorganic & medicinal chemistry letters, 2008-09, Vol.18 (18), p.5063-5065

2008

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Structure-Based Design of Macrocyclic Factor XIa Inhibitors: Discovery of the Macrocyclic Amide Linker

Journal of medicinal chemistry, 2017-02, Vol.60 (3), p.1060-1075

2017

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Discovery of a small molecule antagonist of the parathyroid hormone receptor by using an N-terminal parathyroid hormone peptide probe

Proceedings of the National Academy of Sciences - PNAS, 2007-04, Vol.104 (16), p.6846-6851

2007

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Discovery and Evaluation of BMS-708163, a Potent, Selective and Orally Bioavailable γ-Secretase Inhibitor

ACS medicinal chemistry letters, 2010-06, Vol.1 (3), p.120-124

2010

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Discovery and Structure−Activity Relationship of N-(Ureidoalkyl)-Benzyl-Piperidines As Potent Small Molecule CC Chemokine Receptor-3 (CCR3) Antagonists

Journal of medicinal chemistry, 2002-08, Vol.45 (17), p.3794-3804

2002

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A new synthesis of cytoxazone and its diastereomers provides key initial SAR information

Bioorganic & medicinal chemistry letters, 2003-04, Vol.13 (7), p.1237-1239

2003

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Role of P-glycoprotein and the intestine in the excretion of DPC 333 [(2R)-2-{(3R)-3-amino-3-[4-(2-methylquinolin-4-ylmethoxy)phenyl]-2-oxopyrrolidin-1-yl}-N-hydroxy-4-methylpentanamide] in rodents

Drug metabolism and disposition, 2008-06, Vol.36 (6), p.1102

2008

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Therapeutic Potential and Strategies for Inhibiting Tumor Necrosis Factor-α

Journal of medicinal chemistry, 1999-07, Vol.42 (13), p.2295-2314

1999

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Cloning and Characterization of ADAMTS11 , an Aggrecanase from the ADAMTS Family

The Journal of biological chemistry, 1999-08, Vol.274 (33), p.23443-23450

1999

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Intramolecular O-Arylation of Phenols with Phenylboronic Acids: Application to the Synthesis of Macrocyclic Metalloproteinase Inhibitors

Organic letters, 2001-04, Vol.3 (7), p.1029-1032

2001

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Asymmetric Synthesis of trans-2,3-Piperidinedicarboxylic Acid and trans-3,4-Piperidinedicarboxylic Acid Derivatives

Journal of organic chemistry, 2002-02, Vol.67 (3), p.865-870

2002

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Total Asymmetric Synthesis of the Potent Immunosuppressive Marine Natural Product Microcolin A

Journal of organic chemistry, 1996-05, Vol.61 (10), p.3534-3541

1996

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Alkylsulfone-containing trisubstituted cyclohexanes as potent and bioavailable chemokine receptor 2 (CCR2) antagonists

Bioorganic & medicinal chemistry letters, 2014-04, Vol.24 (7), p.1843-1845

2014

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Photochemically Enhanced Binding of Small Molecules to the Tumor Necrosis Factor Receptor-1 Inhibits the Binding of TNF-α

Proceedings of the National Academy of Sciences - PNAS, 2001-10, Vol.98 (21), p.11879-11884

2001

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Inhibition of tumor necrosis factor-alpha-converting enzyme by a selective antagonist protects brain from focal ischemic injury in rats

Molecular pharmacology, 2004-04, Vol.65 (4), p.890-896

2004

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Hydantoins, triazolones, and imidazolones as selective non-hydroxamate inhibitors of tumor necrosis factor-α converting enzyme (TACE)

Bioorganic & medicinal chemistry letters, 2007-05, Vol.17 (10), p.2769-2774

2007

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Discovery of γ-Lactam Hydroxamic Acids as Selective Inhibitors of Tumor Necrosis Factor α Converting Enzyme: Design, Synthesis, and Structure−Activity Relationships

Journal of medicinal chemistry, 2002-11, Vol.45 (23), p.4954-4957

2002

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Discovery of low nanomolar non-hydroxamate inhibitors of tumor necrosis factor-α converting enzyme (TACE)

Bioorganic & medicinal chemistry letters, 2007, Vol.17 (1), p.266-271

2007

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Pharmacokinetics and pharmacodynamics of DPC 333 ((2R)-2-((3R)-3-amino-3{4-[2-methyl-4-quinolinyl) methoxy] phenyl}-2-oxopyrrolidinyl)-N-hydroxy-4-methylpentanamide)), a potent and selective inhibitor of tumor necrosis factor alpha-converting enzyme in rodents, dogs, chimpanzees, and humans

Drug metabolism and disposition, 2007-10, Vol.35 (10), p.1916

2007

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Benzimidazoles as benzamide replacements within cyclohexane-based CC chemokine receptor 2 (CCR2) antagonists

Bioorganic & medicinal chemistry letters, 2012-10, Vol.22 (19), p.6181-6184

2012

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γ-Lactams as glycinamide replacements in cyclohexane-based CC chemokine receptor 2 (CCR2) antagonists

Bioorganic & medicinal chemistry letters, 2010-04, Vol.20 (8), p.2425-2430

2010

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Discovery of Disubstituted Cyclohexanes as a New Class of CC Chemokine Receptor 2 Antagonists

α,β-Cyclic-β-benzamido hydroxamic acids: Novel templates for the design, synthesis, and evaluation of selective inhibitors of TNF-α converting enzyme (TACE)

N-in-1 Dosing Pharmacokinetics in Drug Discovery: Experience, Theoretical and Practical Considerations

Discovery of trisubstituted cyclohexanes as potent CC chemokine receptor 2 (CCR2) antagonists

Synthesis and evaluation of cis-3,4-disubstituted piperidines as potent CC chemokine receptor 2 (CCR2) antagonists

Structure-Based Design of Macrocyclic Factor XIa Inhibitors: Discovery of the Macrocyclic Amide Linker

Discovery of a small molecule antagonist of the parathyroid hormone receptor by using an N-terminal parathyroid hormone peptide probe

Discovery and Evaluation of BMS-708163, a Potent, Selective and Orally Bioavailable γ-Secretase Inhibitor

Discovery and Structure−Activity Relationship of N-(Ureidoalkyl)-Benzyl-Piperidines As Potent Small Molecule CC Chemokine Receptor-3 (CCR3) Antagonists

A new synthesis of cytoxazone and its diastereomers provides key initial SAR information

Role of P-glycoprotein and the intestine in the excretion of DPC 333 [(2R)-2-{(3R)-3-amino-3-[4-(2-methylquinolin-4-ylmethoxy)phenyl]-2-oxopyrrolidin-1-yl}-N-hydroxy-4-methylpentanamide] in rodents

Therapeutic Potential and Strategies for Inhibiting Tumor Necrosis Factor-α

Cloning and Characterization of ADAMTS11 , an Aggrecanase from the ADAMTS Family

Intramolecular O-Arylation of Phenols with Phenylboronic Acids: Application to the Synthesis of Macrocyclic Metalloproteinase Inhibitors

Asymmetric Synthesis of trans-2,3-Piperidinedicarboxylic Acid and trans-3,4-Piperidinedicarboxylic Acid Derivatives

Total Asymmetric Synthesis of the Potent Immunosuppressive Marine Natural Product Microcolin A

Alkylsulfone-containing trisubstituted cyclohexanes as potent and bioavailable chemokine receptor 2 (CCR2) antagonists

Photochemically Enhanced Binding of Small Molecules to the Tumor Necrosis Factor Receptor-1 Inhibits the Binding of TNF-α

Inhibition of tumor necrosis factor-alpha-converting enzyme by a selective antagonist protects brain from focal ischemic injury in rats

Hydantoins, triazolones, and imidazolones as selective non-hydroxamate inhibitors of tumor necrosis factor-α converting enzyme (TACE)

Discovery of γ-Lactam Hydroxamic Acids as Selective Inhibitors of Tumor Necrosis Factor α Converting Enzyme: Design, Synthesis, and Structure−Activity Relationships

Discovery of low nanomolar non-hydroxamate inhibitors of tumor necrosis factor-α converting enzyme (TACE)

Pharmacokinetics and pharmacodynamics of DPC 333 ((2R)-2-((3R)-3-amino-3{4-[2-methyl-4-quinolinyl) methoxy] phenyl}-2-oxopyrrolidinyl)-N-hydroxy-4-methylpentanamide)), a potent and selective inhibitor of tumor necrosis factor alpha-converting enzyme in rodents, dogs, chimpanzees, and humans

Benzimidazoles as benzamide replacements within cyclohexane-based CC chemokine receptor 2 (CCR2) antagonists

γ-Lactams as glycinamide replacements in cyclohexane-based CC chemokine receptor 2 (CCR2) antagonists

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