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Block-And-Lock Strategies to Cure HIV Infection

Viruses, 2020-01, Vol.12 (1), p.84

2020

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Allele specific repair of splicing mutations in cystic fibrosis through AsCas12a genome editing

Nature communications, 2019-08, Vol.10 (1), p.3556-11, Article 3556

2019

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Towards a Functional Cure of HIV-1: Insight Into the Chromatin Landscape of the Provirus

Frontiers in microbiology, 2021-03, Vol.12, p.636642-636642

2021

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Establishment of latent HIV-1 reservoirs: what do we really know?

Journal of Virus Eradication, 2019-01, Vol.5 (1), p.3-9

2019

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Single-Cell Imaging Shows That the Transcriptional State of the HIV-1 Provirus and Its Reactivation Potential Depend on the Integration Site

mBio, 2022-08, Vol.13 (4), p.e0000722-e0000722

2022

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Determinants of Retroviral Integration and Implications for Gene Therapeutic MLV-Based Vectors and for a Cure for HIV-1 Infection

Viruses, 2022-12, Vol.15 (1), p.32

2022

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Rational design of small-molecule inhibitors of the LEDGF/p75-integrase interaction and HIV replication

Nature chemical biology, 2010-06, Vol.6 (6), p.442

2010

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Genetic variation of the HIV-1 subtype C transmitted/founder viruses long terminal repeat elements and the impact on transcription activation potential and clinical disease outcomes

PLoS pathogens, 2023-06, Vol.19 (6), p.e1011194-e1011194

2023

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GS-9822, a preclinical LEDGIN candidate, displays a block-and-lock phenotype in cell culture

Antimicrobial agents and chemotherapy, 2021-04, Vol.65 (5)

2021

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Author Correction: Allele specific repair of splicing mutations in cystic fibrosis through AsCas12a genome editing

Nature communications, 2020-10, Vol.11 (1), p.5457-5457, Article 5457

2020

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A ubiquitous disordered protein interaction module orchestrates transcription elongation

Science (American Association for the Advancement of Science), 2021-11, Vol.374 (6571), p.1113-1121

2021

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Small-Molecule Inhibitors of the LEDGF/p75 Binding Site of Integrase Block HIV Replication and Modulate Integrase Multimerization

Antimicrobial Agents and Chemotherapy, 2012-08, Vol.56 (8), p.4365-4374

2012

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Insight in HIV Integration Site Selection Provides a Block-and-Lock Strategy for a Functional Cure of HIV Infection

Viruses, 2018-12, Vol.11 (1), p.12

2018

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Pharmacological advances in anti‐retroviral therapy for human immunodeficiency virus‐1 infection: A comprehensive review

Reviews in medical virology, 2024-03, Vol.34 (2), p.e2529-n/a

2024

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Design of reverse transcriptase–specific nucleosides to visualize early steps of HIV-1 replication by click labeling

The Journal of biological chemistry, 2019-08, Vol.294 (31), p.11863-11875

2019

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Quad's in it for antiretroviral therapy?

The Lancet (British edition), 2012-06, Vol.379 (9835), p.2403-2405

2012

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LEDGF/p75-mediated chemoresistance of mixed-lineage leukemia involves cell survival pathways and super enhancer activators

Cancer gene therapy, 2022-02, Vol.29 (2), p.133-140

2022

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Towards a Safer, More Randomized Lentiviral Vector Integration Profile Exploring Artificial LEDGF Chimeras

PloS one, 2016-10, Vol.11 (10), p.e0164167

2016

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The BET Family of Proteins Targets Moloney Murine Leukemia Virus Integration near Transcription Start Sites

Cell reports (Cambridge), 2013-11, Vol.5 (4), p.886-894

2013

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LEDGF/p75-independent HIV-1 replication demonstrates a role for HRP-2 and remains sensitive to inhibition by LEDGINs

PLoS pathogens, 2012-03, Vol.8 (3), p.e1002558

2012

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LEDGINs, non-catalytic site inhibitors of HIV-1 integrase: a patent review (2006 - 2014)

Expert opinion on therapeutic patents, 2014-06, Vol.24 (6), p.609-632

2014

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Magnesium Chelating 2-Hydroxyisoquinoline-1,3(2H,4H)-diones, as Inhibitors of HIV-1 Integrase and/or the HIV-1 Reverse Transcriptase Ribonuclease H Domain: Discovery of a Novel Selective Inhibitor of the Ribonuclease H Function

Journal of medicinal chemistry, 2011-03, Vol.54 (6), p.1812-1824

2011

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The HIV-2 OGH double reporter virus shows that HIV-2 is less cytotoxic and less sensitive to reactivation from latency than HIV-1 in cell culture

Journal of Virus Eradication, 2023-09, Vol.9 (3), p.100343-100343, Article 100343

2023

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The free energy landscape of retroviral integration

Nature communications, 2019-10, Vol.10 (1), p.4738-11, Article 4738

2019

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Block-And-Lock Strategies to Cure HIV Infection

Allele specific repair of splicing mutations in cystic fibrosis through AsCas12a genome editing

Towards a Functional Cure of HIV-1: Insight Into the Chromatin Landscape of the Provirus

Establishment of latent HIV-1 reservoirs: what do we really know?

Single-Cell Imaging Shows That the Transcriptional State of the HIV-1 Provirus and Its Reactivation Potential Depend on the Integration Site

Determinants of Retroviral Integration and Implications for Gene Therapeutic MLV-Based Vectors and for a Cure for HIV-1 Infection

Rational design of small-molecule inhibitors of the LEDGF/p75-integrase interaction and HIV replication

Genetic variation of the HIV-1 subtype C transmitted/founder viruses long terminal repeat elements and the impact on transcription activation potential and clinical disease outcomes

GS-9822, a preclinical LEDGIN candidate, displays a block-and-lock phenotype in cell culture

Author Correction: Allele specific repair of splicing mutations in cystic fibrosis through AsCas12a genome editing

A ubiquitous disordered protein interaction module orchestrates transcription elongation

Small-Molecule Inhibitors of the LEDGF/p75 Binding Site of Integrase Block HIV Replication and Modulate Integrase Multimerization

Insight in HIV Integration Site Selection Provides a Block-and-Lock Strategy for a Functional Cure of HIV Infection

Pharmacological advances in anti‐retroviral therapy for human immunodeficiency virus‐1 infection: A comprehensive review

Design of reverse transcriptase–specific nucleosides to visualize early steps of HIV-1 replication by click labeling

Quad's in it for antiretroviral therapy?

LEDGF/p75-mediated chemoresistance of mixed-lineage leukemia involves cell survival pathways and super enhancer activators

Towards a Safer, More Randomized Lentiviral Vector Integration Profile Exploring Artificial LEDGF Chimeras

The BET Family of Proteins Targets Moloney Murine Leukemia Virus Integration near Transcription Start Sites

LEDGF/p75-independent HIV-1 replication demonstrates a role for HRP-2 and remains sensitive to inhibition by LEDGINs

LEDGINs, non-catalytic site inhibitors of HIV-1 integrase: a patent review (2006 - 2014)

Magnesium Chelating 2-Hydroxyisoquinoline-1,3(2H,4H)-diones, as Inhibitors of HIV-1 Integrase and/or the HIV-1 Reverse Transcriptase Ribonuclease H Domain: Discovery of a Novel Selective Inhibitor of the Ribonuclease H Function

Differential Effects of Progenitor Cell Populations on Left Ventricular Remodeling and Myocardial Neovascularization After Myocardial Infarction

The HIV-2 OGH double reporter virus shows that HIV-2 is less cytotoxic and less sensitive to reactivation from latency than HIV-1 in cell culture

The free energy landscape of retroviral integration

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