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Exposing the DRome (DNA Repair-ome)

Acta crystallographica. Section A, Foundations and advances, 2022-07, Vol.78 (a1), p.a23-a23

Das, Debanu

2022

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signaling phospholipid PIP₃ creates a new interaction surface on the nuclear receptor SF-1

Proceedings of the National Academy of Sciences - PNAS, 2014-10, Vol.111 (42), p.15054-15059

2014

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Deploying high-throughput protein crystallography-based drug discovery platforms to establish a structure-based drug discovery system for SARS-CoV-2 proteins

Acta crystallographica. Section A, Foundations and advances, 2021-07, Vol.77 (a1), p.a12-a12

Das, Debanu

2021

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A New Drug Discovery Platform: Application to DNA Polymerase Eta and Apurinic/Apyrimidinic Endonuclease 1

International journal of molecular sciences, 2023-11, Vol.24 (23), p.16637

2023

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Early Drug Discovery and Development of Novel Cancer Therapeutics Targeting DNA Polymerase Eta (POLH)

Frontiers in oncology, 2021-11, Vol.11, p.778925-778925

2021

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Empirical lead generation by crystallographic screening of fragment libraries

Acta crystallographica. Section A, Foundations and advances, 2019-07, Vol.75 (a1), p.a425-a425

Das, Debanu

2019

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Structure-based discovery of NANOG variant with enhanced properties to promote self-renewal and reprogramming of pluripotent stem cells

Proceedings of the National Academy of Sciences - PNAS, 2015-04, Vol.112 (15), p.4666-4671

2015

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Taking care of business: new drivers for crystallographic structure- and fragment-based drug discovery

Acta crystallographica. Section A, Foundations and advances, 2018-07, Vol.74 (a1), p.a245-a245

Das, Debanu

2018

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UHM-ULM interactions in the RBM39-U2AF65 splicing-factor complex

Acta crystallographica. Section D, Structural biology, 2016-04, Vol.72 (4), p.497-511

2016

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The Crystal Structure of the Monomeric Reverse Transcriptase from Moloney Murine Leukemia Virus

Structure (London), 2004-05, Vol.12 (5), p.819-829

2004

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Structure and Function of a Novel ld-Carboxypeptidase A Involved in Peptidoglycan Recycling

Journal of Bacteriology, 2013-12, Vol.195 (24), p.5555-5566

2013

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Rapid hits, hotspots and hit-to-lead by crystallographic library screening: case studies in targeting proteins for novel drug discovery

Acta crystallographica. Section A, Foundations and advances, 2023-08, Vol.79 (a2), p.C346-C346

2023

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Structure and function of the first full-length murein peptide ligase (Mpl) cell wall recycling protein

PloS one, 2011-03, Vol.6 (3), p.e17624

2011

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Development of a DNA damage response (DDR) therapeutics platform for oncology

Journal of clinical oncology, 2021-05, Vol.39 (15_suppl), p.e15036-e15036

2021

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Abstract B053: Applying a new drug discovery platform for the discovery and development of inhibitors of DDR proteins APE1 and Pol eta

Molecular cancer therapeutics, 2023-12, Vol.22 (12_Supplement), p.B053-B053

2023

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Improved molecular replacement by density- and energy-guided protein structure optimization

Nature (London), 2011-05, Vol.473 (7348), p.540-543

2011

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Crystal structure of a novel single-stranded DNA binding protein from Mycoplasma pneumoniae

Proteins, structure, function, and bioinformatics, 2007-05, Vol.67 (3), p.776-782

2007

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Fragment- and structure-based drug discovery for developing therapeutic agents targeting the DNA Damage Response

Progress in biophysics and molecular biology, 2021-08, Vol.163 (C)

2021

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Fragment- and structure-based drug discovery for developing therapeutic agents targeting the DNA Damage Response

Progress in biophysics and molecular biology, 2021-08, Vol.163, p.130-142

2021

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The Signaling Phospholipid PIP 3 Functions As a Ligand Hormone For Nuclear Receptors

The FASEB journal, 2015-04, Vol.29 (S1)

2015

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A directed approach to improving the solubility of Moloney murine leukemia virus reverse transcriptase

Protein science, 2001-10, Vol.10 (10), p.1936-1941

2001

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Structure of Liver Receptor Homolog-1 (NR5A2) with PIP3 hormone bound in the ligand binding pocket

Journal of structural biology, 2015-12, Vol.192 (3), p.342-348

2015

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Crystal Structure and Activity Studies of the C11 Cysteine Peptidase from Parabacteroides merdae in the Human Gut Microbiome

The Journal of biological chemistry, 2016-04, Vol.291 (18), p.9482-9491

2016

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PNT1 Is a C11 Cysteine Peptidase Essential for Replication of the Trypanosome Kinetoplast

The Journal of biological chemistry, 2016-04, Vol.291 (18), p.9492-9500

2016

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The signaling phospholipid PIP^sub 3^ creates a new interaction surface on the nuclear receptor SF-1

Proceedings of the National Academy of Sciences - PNAS, 2014-10, Vol.111 (42), p.15054

2014

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Exposing the DRome (DNA Repair-ome)

signaling phospholipid PIP₃ creates a new interaction surface on the nuclear receptor SF-1

Deploying high-throughput protein crystallography-based drug discovery platforms to establish a structure-based drug discovery system for SARS-CoV-2 proteins

A New Drug Discovery Platform: Application to DNA Polymerase Eta and Apurinic/Apyrimidinic Endonuclease 1

Early Drug Discovery and Development of Novel Cancer Therapeutics Targeting DNA Polymerase Eta (POLH)

Empirical lead generation by crystallographic screening of fragment libraries

Structure-based discovery of NANOG variant with enhanced properties to promote self-renewal and reprogramming of pluripotent stem cells

Taking care of business: new drivers for crystallographic structure- and fragment-based drug discovery

UHM-ULM interactions in the RBM39-U2AF65 splicing-factor complex

The Crystal Structure of the Monomeric Reverse Transcriptase from Moloney Murine Leukemia Virus

Structure and Function of a Novel ld-Carboxypeptidase A Involved in Peptidoglycan Recycling

Rapid hits, hotspots and hit-to-lead by crystallographic library screening: case studies in targeting proteins for novel drug discovery

Structure and function of the first full-length murein peptide ligase (Mpl) cell wall recycling protein

Development of a DNA damage response (DDR) therapeutics platform for oncology

Abstract B053: Applying a new drug discovery platform for the discovery and development of inhibitors of DDR proteins APE1 and Pol eta

Improved molecular replacement by density- and energy-guided protein structure optimization

Crystal structure of a novel single-stranded DNA binding protein from Mycoplasma pneumoniae

Fragment- and structure-based drug discovery for developing therapeutic agents targeting the DNA Damage Response

Fragment- and structure-based drug discovery for developing therapeutic agents targeting the DNA Damage Response

The Signaling Phospholipid PIP 3 Functions As a Ligand Hormone For Nuclear Receptors

A directed approach to improving the solubility of Moloney murine leukemia virus reverse transcriptase

Structure of Liver Receptor Homolog-1 (NR5A2) with PIP3 hormone bound in the ligand binding pocket

Crystal Structure and Activity Studies of the C11 Cysteine Peptidase from Parabacteroides merdae in the Human Gut Microbiome

PNT1 Is a C11 Cysteine Peptidase Essential for Replication of the Trypanosome Kinetoplast

The signaling phospholipid PIP^sub 3^ creates a new interaction surface on the nuclear receptor SF-1

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