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Advances and Challenges in Targeting TGF-β Isoforms for Therapeutic Intervention of Cancer: A Mechanism-Based Perspective

Pharmaceuticals (Basel, Switzerland), 2024-04, Vol.17 (4), p.533

Danielpour, David

2024

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Functions and regulation of transforming growth factor-beta (TGF-β) in the prostate

European journal of cancer (1990), 2005-04, Vol.41 (6), p.846-857

Danielpour, David

2005

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Mammalian target of rapamycin inhibition as a therapeutic strategy in the management of urologic malignancies

Molecular cancer therapeutics, 2008-06, Vol.7 (6), p.1347-1354

2008

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Jagged-1 is induced by mTOR inhibitors in renal cancer cells through an Akt/ALK5/Smad4-dependent mechanism

Current research in pharmacology and drug discovery, 2022-01, Vol.3, p.100117-100117, Article 100117

2022

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TGF-β signaling engages an ATM-CHK2-p53—independent RAS-induced senescence and prevents malignant transformation in human mammary epithelial cells

Proceedings of the National Academy of Sciences - PNAS, 2011-05, Vol.108 (21), p.8668-8673

2011

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Early Cellular Responses of Prostate Carcinoma Cells to Sepantronium Bromide (YM155) Involve Suppression of mTORC1 by AMPK

Scientific reports, 2019-08, Vol.9 (1), p.11541-17, Article 11541

2019

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Deptor Enhances Triple-Negative Breast Cancer Metastasis and Chemoresistance through Coupling to Survivin Expression

Neoplasia (New York, N.Y.), 2015-03, Vol.17 (3), p.317-328

2015

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Upregulation of SATB1 is associated with prostate cancer aggressiveness and disease progression

PloS one, 2013-01, Vol.8 (1), p.e53527-e53527

2013

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Critical role of a survivin/TGF-β/mTORC1 axis in IGF-I-mediated growth of prostate epithelial cells

PloS one, 2013-05, Vol.8 (5), p.e61896-e61896

2013

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Hypoxia represses early responses of prostate and renal cancer cells to YM155 independent of HIF-1α and HIF-2α

Current research in pharmacology and drug discovery, 2022-01, Vol.3, p.100076-100076, Article 100076

2022

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Posterior Hox Gene Expression and Differential Androgen Regulation in the Developing and Adult Rat Prostate Lobes

Endocrinology (Philadelphia), 2007-03, Vol.148 (3), p.1235-1245

2007

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Tocopherol transfer protein sensitizes prostate cancer cells to vitamin E

The Journal of biological chemistry, 2015-10, Vol.290 (43), p.25848-25848

2015

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Cited2, a Transcriptional Modulator Protein, Regulates Metabolism in Murine Embryonic Stem Cells

The Journal of biological chemistry, 2014-01, Vol.289 (1), p.251-263

2014

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Protein Kinase C-mediated Down-regulation of Cyclin D1 Involves Activation of the Translational Repressor 4E-BP1 via a Phosphoinositide 3-Kinase/Akt-independent, Protein Phosphatase 2A-dependent Mechanism in Intestinal Epithelial Cells

The Journal of biological chemistry, 2007-05, Vol.282 (19), p.14213-14225

2007

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Cited2 is required for the maintenance of glycolytic metabolism in adult hematopoietic stem cells

Stem cells and development, 2014-01, Vol.23 (2), p.83-94

2014

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Novel Function of Androgen Receptor-associated Protein 55/Hic-5 as a Negative Regulator of Smad3 Signaling

The Journal of biological chemistry, 2005-02, Vol.280 (7), p.5154-5162

2005

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Ski Acts as a Co-Repressor with Smad2 and Smad3 to Regulate the Response to Type β Transforming Growth Factor

Proceedings of the National Academy of Sciences - PNAS, 2000-05, Vol.97 (11), p.5924-5929

2000

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TGF-β upregulates miR-181a expression to promote breast cancer metastasis

The Journal of clinical investigation, 2013-01, Vol.123 (1), p.150-163

2013

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JAB1/COPS5 is a putative oncogene that controls critical oncoproteins deregulated in prostate cancer

Biochemical and biophysical research communications, 2019-10, Vol.518 (2), p.374-380

2019

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The Presenilin-2 Loop Peptide Perturbs Intracellular Ca2+ Homeostasis and Accelerates Apoptosis

The Journal of biological chemistry, 2006-06, Vol.281 (24), p.16649-16655

2006

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The crucial p53-dependent oncogenic role of JAB1 in osteosarcoma in vivo

Oncogene, 2020-06, Vol.39 (23), p.4581-4591

2020

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EphA2 Mediates Ligand-Dependent Inhibition and Ligand-Independent Promotion of Cell Migration and Invasion via a Reciprocal Regulatory Loop with Akt

Cancer cell, 2009-07, Vol.16 (1), p.9-20

2009

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FLICE-Like Inhibitory Protein Blocks Transforming Growth Factor β1–Induced Caspase Activation and Apoptosis in Prostate Epithelial Cells

Molecular cancer research, 2008-02, Vol.6 (2), p.231-242

2008

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Abstract 1804: New insights in the induction of cell death by the imidazolium based compound YM155

Cancer research (Chicago, Ill.), 2014-10, Vol.74 (19_Supplement), p.1804-1804

2014

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Critical Role of Smad2 in Tumor Suppression and Transforming Growth Factor-β-induced Apoptosis of Prostate Epithelial Cells

Cancer research (Chicago, Ill.), 2009-03, Vol.69 (6), p.2185-2190

2009

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Advances and Challenges in Targeting TGF-β Isoforms for Therapeutic Intervention of Cancer: A Mechanism-Based Perspective

Functions and regulation of transforming growth factor-beta (TGF-β) in the prostate

Mammalian target of rapamycin inhibition as a therapeutic strategy in the management of urologic malignancies

Jagged-1 is induced by mTOR inhibitors in renal cancer cells through an Akt/ALK5/Smad4-dependent mechanism

TGF-β signaling engages an ATM-CHK2-p53—independent RAS-induced senescence and prevents malignant transformation in human mammary epithelial cells

Early Cellular Responses of Prostate Carcinoma Cells to Sepantronium Bromide (YM155) Involve Suppression of mTORC1 by AMPK

Deptor Enhances Triple-Negative Breast Cancer Metastasis and Chemoresistance through Coupling to Survivin Expression

Upregulation of SATB1 is associated with prostate cancer aggressiveness and disease progression

Critical role of a survivin/TGF-β/mTORC1 axis in IGF-I-mediated growth of prostate epithelial cells

Hypoxia represses early responses of prostate and renal cancer cells to YM155 independent of HIF-1α and HIF-2α

Posterior Hox Gene Expression and Differential Androgen Regulation in the Developing and Adult Rat Prostate Lobes

Tocopherol transfer protein sensitizes prostate cancer cells to vitamin E

Cited2, a Transcriptional Modulator Protein, Regulates Metabolism in Murine Embryonic Stem Cells

Protein Kinase C-mediated Down-regulation of Cyclin D1 Involves Activation of the Translational Repressor 4E-BP1 via a Phosphoinositide 3-Kinase/Akt-independent, Protein Phosphatase 2A-dependent Mechanism in Intestinal Epithelial Cells

Cited2 is required for the maintenance of glycolytic metabolism in adult hematopoietic stem cells

Novel Function of Androgen Receptor-associated Protein 55/Hic-5 as a Negative Regulator of Smad3 Signaling

Ski Acts as a Co-Repressor with Smad2 and Smad3 to Regulate the Response to Type β Transforming Growth Factor

TGF-β upregulates miR-181a expression to promote breast cancer metastasis

JAB1/COPS5 is a putative oncogene that controls critical oncoproteins deregulated in prostate cancer

The Presenilin-2 Loop Peptide Perturbs Intracellular Ca2+ Homeostasis and Accelerates Apoptosis

The crucial p53-dependent oncogenic role of JAB1 in osteosarcoma in vivo

EphA2 Mediates Ligand-Dependent Inhibition and Ligand-Independent Promotion of Cell Migration and Invasion via a Reciprocal Regulatory Loop with Akt

FLICE-Like Inhibitory Protein Blocks Transforming Growth Factor β1–Induced Caspase Activation and Apoptosis in Prostate Epithelial Cells

Abstract 1804: New insights in the induction of cell death by the imidazolium based compound YM155

Critical Role of Smad2 in Tumor Suppression and Transforming Growth Factor-β-induced Apoptosis of Prostate Epithelial Cells

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