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One ring to rule them all: Trafficking of heme and heme synthesis intermediates in the metazoans

Biochimica et biophysica acta, 2012-09, Vol.1823 (9), p.1617-1632

2012

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Prokaryotic Heme Biosynthesis: Multiple Pathways to a Common Essential Product

Microbiology and molecular biology reviews, 2017-03, Vol.81 (1)

2017

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Noncanonical coproporphyrin-dependent bacterial heme biosynthesis pathway that does not use protoporphyrin

Proceedings of the National Academy of Sciences - PNAS, 2015-02, Vol.112 (7), p.2210-2215

2015

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New Avenues of Heme Synthesis Regulation

International journal of molecular sciences, 2022-07, Vol.23 (13), p.7467

2022

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Identification of the Mitochondrial Heme Metabolism Complex

PloS one, 2015-08, Vol.10 (8), p.e0135896

2015

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HemQ: An iron-coproporphyrin oxidative decarboxylase for protoheme synthesis in Firmicutes and Actinobacteria

Archives of biochemistry and biophysics, 2015-05, Vol.574 (C), p.27-35

2015

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Human aminolevulinate synthase structure reveals a eukaryotic-specific autoinhibitory loop regulating substrate binding and product release

Nature communications, 2020-06, Vol.11 (1), p.2813-12, Article 2813

2020

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Impact of Phosphorylation at Various Sites on the Active Pocket of Human Ferrochelatase: Insights from Molecular Dynamics Simulations

International journal of molecular sciences, 2024-06, Vol.25 (12), p.6360

2024

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The mitochondrial heme metabolon: Insights into the complex(ity) of heme synthesis and distribution

Molecular genetics and metabolism, 2019-11, Vol.128 (3), p.198-203

2019

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The alternative coproporphyrinogen III oxidase (CgoN) catalyzes the oxygen-independent conversion of coproporphyrinogen III into coproporphyrin III

Frontiers in microbiology, 2024-03, Vol.15, p.1378989-1378989

2024

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Glutamine via α-ketoglutarate dehydrogenase provides succinyl-CoA for heme synthesis during erythropoiesis

Blood, 2018-09, Vol.132 (10), p.987-998

2018

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An Intercellular Heme-Trafficking Protein Delivers Maternal Heme to the Embryo during Development in C. elegans

Cell, 2011-05, Vol.145 (5), p.720-731

2011

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Ferrochelatase: Mapping the Intersection of Iron and Porphyrin Metabolism in the Mitochondria

Frontiers in cell and developmental biology, 2022-05, Vol.10, p.894591-894591

2022

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Exploiting Differences in Heme Biosynthesis between Bacterial Species to Screen for Novel Antimicrobials

Biomolecules (Basel, Switzerland), 2023-10, Vol.13 (10), p.1485

2023

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Rapid and sensitive quantitation of heme in hemoglobinized cells

BioTechniques, 2016-08, Vol.61 (2), p.83-91

2016

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Mitochondrial contact site and cristae organizing system (MICOS) machinery supports heme biosynthesis by enabling optimal performance of ferrochelatase

Redox biology, 2021-10, Vol.46, p.102125, Article 102125

2021

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Proteomic Analysis of Ferrochelatase Interactome in Erythroid and Non-Erythroid Cells

Life (Basel, Switzerland), 2023-02, Vol.13 (2), p.577

2023

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Substrate interactions with human ferrochelatase

Proceedings of the National Academy of Sciences - PNAS, 2007-02, Vol.104 (6), p.1789-1793

2007

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Loss-of-function ferrochelatase and gain-of-function erythroid-specific 5-aminolevulinate synthase mutations causing erythropoietic protoporphyria and x-linked protoporphyria in North American patients reveal novel mutations and a high prevalence of X-linked protoporphyria

Molecular medicine (Cambridge, Mass.), 2013-01, Vol.19 (1), p.26-29

2013

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Erythropoietin signaling regulates heme biosynthesis

eLife, 2017-05, Vol.6

2017

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Product Release Rather than Chelation Determines Metal Specificity for Ferrochelatase

Journal of molecular biology, 2009-10, Vol.393 (2), p.308-319

2009

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Interdomain lateral gene transfer of an essential ferrochelatase gene in human parasitic nematodes

Proceedings of the National Academy of Sciences - PNAS, 2013-05, Vol.110 (19), p.7748-7753

2013

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Exogenously Scavenged and Endogenously Synthesized Heme Are Differentially Utilized by Mycobacterium tuberculosis

Microbiology spectrum, 2022-10, Vol.10 (5), p.e0360422

2022

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A new class of [2Fe-2S]-cluster-containing protoporphyrin (IX) ferrochelatases

Biochemical journal, 2006-07, Vol.397 (1), p.47-52

2006

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The Escherichia coli protein YfeX functions as a porphyrinogen oxidase, not a heme dechelatase

mBio, 2011, Vol.2 (6), p.e00248-e00211

2011

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One ring to rule them all: Trafficking of heme and heme synthesis intermediates in the metazoans

Prokaryotic Heme Biosynthesis: Multiple Pathways to a Common Essential Product

Noncanonical coproporphyrin-dependent bacterial heme biosynthesis pathway that does not use protoporphyrin

New Avenues of Heme Synthesis Regulation

Identification of the Mitochondrial Heme Metabolism Complex

HemQ: An iron-coproporphyrin oxidative decarboxylase for protoheme synthesis in Firmicutes and Actinobacteria

Human aminolevulinate synthase structure reveals a eukaryotic-specific autoinhibitory loop regulating substrate binding and product release

Impact of Phosphorylation at Various Sites on the Active Pocket of Human Ferrochelatase: Insights from Molecular Dynamics Simulations

The mitochondrial heme metabolon: Insights into the complex(ity) of heme synthesis and distribution

The alternative coproporphyrinogen III oxidase (CgoN) catalyzes the oxygen-independent conversion of coproporphyrinogen III into coproporphyrin III

Glutamine via α-ketoglutarate dehydrogenase provides succinyl-CoA for heme synthesis during erythropoiesis

An Intercellular Heme-Trafficking Protein Delivers Maternal Heme to the Embryo during Development in C. elegans

Ferrochelatase: Mapping the Intersection of Iron and Porphyrin Metabolism in the Mitochondria

Exploiting Differences in Heme Biosynthesis between Bacterial Species to Screen for Novel Antimicrobials

Rapid and sensitive quantitation of heme in hemoglobinized cells

Mitochondrial contact site and cristae organizing system (MICOS) machinery supports heme biosynthesis by enabling optimal performance of ferrochelatase

Proteomic Analysis of Ferrochelatase Interactome in Erythroid and Non-Erythroid Cells

Substrate interactions with human ferrochelatase

Loss-of-function ferrochelatase and gain-of-function erythroid-specific 5-aminolevulinate synthase mutations causing erythropoietic protoporphyria and x-linked protoporphyria in North American patients reveal novel mutations and a high prevalence of X-linked protoporphyria

Erythropoietin signaling regulates heme biosynthesis

Product Release Rather than Chelation Determines Metal Specificity for Ferrochelatase

Interdomain lateral gene transfer of an essential ferrochelatase gene in human parasitic nematodes

Exogenously Scavenged and Endogenously Synthesized Heme Are Differentially Utilized by Mycobacterium tuberculosis

A new class of [2Fe-2S]-cluster-containing protoporphyrin (IX) ferrochelatases

The Escherichia coli protein YfeX functions as a porphyrinogen oxidase, not a heme dechelatase

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