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Effects of statin therapy on diagnoses of new-onset diabetes and worsening glycaemia in large-scale randomised blinded statin trials: an individual participant data meta-analysis

The lancet. Diabetes & endocrinology, 2024-05, Vol.12 (5), p.306-319

2024

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Long-term cardiovascular risks and the impact of statin treatment on socioeconomic inequalities: a microsimulation model

British journal of general practice, 2024-03, Vol.74 (740), p.e189-e198

2024

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CS1, a controlled‐release formulation of valproic acid, for the treatment of patients with pulmonary arterial hypertension: Rationale and design of a Phase 2 clinical trial

Pulmonary circulation, 2024-01, Vol.14 (1), p.e12323-n/a

2024

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HDAC Inhibitor CS014 Attenuates Thrombosis Alone and in Combination with Rivaroxaban without Increased Risk of Bleeding

Blood, 2023-11, Vol.142 (Supplement 1), p.1195-1195

2023

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The oxylipin analog CS585 prevents platelet activation and thrombosis through activation of the prostacyclin receptor

Blood, 2023-11, Vol.142 (18), p.1556-1569

2023

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CS585 Demonstrates Favorable Selectivity and Sustained In Vivo Action in Preventing Platelet Activation and Thrombosis Compared to Existing IP Receptor Agonists

Blood, 2023-11, Vol.142 (Supplement 1), p.1188-1188

2023

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S309: SUSTAINED INHIBITION OF PLATELET ACTIVITY AND THROMBOSIS VIA IV AND ORAL ADMINISTRATION OF CS585

HemaSphere, 2023-08, Vol.7 (S3), p.e24216e0-n/a

2023

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Abstract 122: The Eicosanoid Analogue Cs585 Represents A First-in-class In Prevention Of Platelet Activation And Thrombosis Through Direct Activation Of The Prostacyclin Receptor

Arteriosclerosis, thrombosis, and vascular biology, 2023-05, Vol.43 (Suppl_1)

2023

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CS585 IS A NOVEL ORALLY AVAILABLE PROSTACYCLIN RECEPTOR AGONIST WITH LONG-TERM IN VIVO INHIBITION OF PLATELETS AND THROMBOSIS FORMATION IN MOUSE WITHOUT INCREASED RISK OF BLEEDING

Journal of the American College of Cardiology, 2023-03, Vol.81 (8), p.2036-2036

2023

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AN INNOVATIVE PHASE 2 CLINICAL TRIAL DESIGN FOR ASSESSMENT OF CS1: A NOVEL THERAPY IN THE TREATMENT OF PULMONARY ARTERIAL HYPERTENSION

Chest, 2022-10, Vol.162 (4), p.A2335-A2336

2022

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Cardiovascular Benefits of Angiotensin-Converting Enzyme Inhibition Plus Calcium Channel Blockade in Patients Achieving Tight Blood Pressure Control and With Resistant Hypertension

American journal of hypertension, 2021-05, Vol.34 (5), p.531-539

2021

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Efficacy and safety of statin therapy in older people: a meta-analysis of individual participant data from 28 randomised controlled trials

The Lancet (British edition), 2019-02, Vol.393 (10170), p.407-415

2019

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Response

Hypertension (Dallas, Tex. 1979), 2019-01 (1)

2019

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Prior Medications and the Cardiovascular Benefits From Combination Angiotensin‐Converting Enzyme Inhibition Plus Calcium Channel Blockade Among High‐Risk Hypertensive Patients

Journal of the American Heart Association, 2018-01, Vol.7 (1), p.n/a

2018

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Adverse events associated with unblinded, but not with blinded, statin therapy in the Anglo-Scandinavian Cardiac Outcomes Trial—Lipid-Lowering Arm (ASCOT-LLA): a randomised double-blind placebo-controlled trial and its non-randomised non-blind extension phase

The Lancet (British edition), 2017-06, Vol.389 (10088), p.2473-2481

2017

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Higher pulse pressure/stroke volume index is associated with impaired outcome in hypertensive patients with left ventricular hypertrophy the LIFE study

Blood pressure, 2017-06, Vol.26 (3), p.150-155

2017

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LBOS 01-04 THE TRUE INCIDENCE OF STATIN -RELATED ADVERSE EVENTS IN HYPERTENSIVE PATIENTS REVEALED BY COMPARISON OF BLINDED AND UN-BLINDED USE OF STATIN IN THE ANGLO-SCANDINAVIAN CARDIAC OUTCOMES TRIAL (ASCOT)

Journal of hypertension, 2016-09, Vol.34 Suppl 1 - ISH 2016 Abstract Book (Supplement 1), p.e547-e548

2016

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Angiotensin AT2-receptor stimulation improves survival and neurological outcome after experimental stroke in mice

Journal of molecular medicine (Berlin, Germany), 2016-08, Vol.94 (8), p.957-966

2016

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Cardiovascular Outcomes According to Systolic Blood Pressure in Patients With and Without Diabetes: An ACCOMPLISH Substudy

The journal of clinical hypertension (Greenwich, Conn.), 2016-04, Vol.18 (4), p.299-307

2016

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Physical activity and exercise lower blood pressure in individuals with hypertension: narrative review of 27 RCTs

British Journal of Sports Medicine, 2016-03, Vol.50 (6), p.356-361

2016

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Blood pressure variability predicts cardiovascular events independently of traditional cardiovascular risk factors and target organ damage: a LIFE substudy

Journal of hypertension, 2015-12, Vol.33 (12), p.2422-2430

2015

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Aerobic physical activity lowers blood pressure in hypertension

Läkartidningen, 2015-11, Vol.112

2015

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Left Ventricular Wall Stress-Mass-Heart Rate Product and Cardiovascular Events in Treated Hypertensive Patients: LIFE Study

Hypertension (Dallas, Tex. 1979), 2015-11, Vol.66 (5), p.945-953

2015

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Effect of Lower On-Treatment Systolic Blood Pressure on the Risk of Atrial Fibrillation in Hypertensive Patients

Hypertension (Dallas, Tex. 1979), 2015-08, Vol.66 (2), p.368-373

2015

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Digoxin use and risk of mortality in hypertensive patients with atrial fibrillation

Journal of hypertension, 2015-07, Vol.33 (7), p.1480-1486

2015

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Effects of statin therapy on diagnoses of new-onset diabetes and worsening glycaemia in large-scale randomised blinded statin trials: an individual participant data meta-analysis

Long-term cardiovascular risks and the impact of statin treatment on socioeconomic inequalities: a microsimulation model

CS1, a controlled‐release formulation of valproic acid, for the treatment of patients with pulmonary arterial hypertension: Rationale and design of a Phase 2 clinical trial

HDAC Inhibitor CS014 Attenuates Thrombosis Alone and in Combination with Rivaroxaban without Increased Risk of Bleeding

The oxylipin analog CS585 prevents platelet activation and thrombosis through activation of the prostacyclin receptor

CS585 Demonstrates Favorable Selectivity and Sustained In Vivo Action in Preventing Platelet Activation and Thrombosis Compared to Existing IP Receptor Agonists

S309: SUSTAINED INHIBITION OF PLATELET ACTIVITY AND THROMBOSIS VIA IV AND ORAL ADMINISTRATION OF CS585

Abstract 122: The Eicosanoid Analogue Cs585 Represents A First-in-class In Prevention Of Platelet Activation And Thrombosis Through Direct Activation Of The Prostacyclin Receptor

CS585 IS A NOVEL ORALLY AVAILABLE PROSTACYCLIN RECEPTOR AGONIST WITH LONG-TERM IN VIVO INHIBITION OF PLATELETS AND THROMBOSIS FORMATION IN MOUSE WITHOUT INCREASED RISK OF BLEEDING

AN INNOVATIVE PHASE 2 CLINICAL TRIAL DESIGN FOR ASSESSMENT OF CS1: A NOVEL THERAPY IN THE TREATMENT OF PULMONARY ARTERIAL HYPERTENSION

Cardiovascular Benefits of Angiotensin-Converting Enzyme Inhibition Plus Calcium Channel Blockade in Patients Achieving Tight Blood Pressure Control and With Resistant Hypertension

Efficacy and safety of statin therapy in older people: a meta-analysis of individual participant data from 28 randomised controlled trials

Response

Prior Medications and the Cardiovascular Benefits From Combination Angiotensin‐Converting Enzyme Inhibition Plus Calcium Channel Blockade Among High‐Risk Hypertensive Patients

Adverse events associated with unblinded, but not with blinded, statin therapy in the Anglo-Scandinavian Cardiac Outcomes Trial—Lipid-Lowering Arm (ASCOT-LLA): a randomised double-blind placebo-controlled trial and its non-randomised non-blind extension phase

Higher pulse pressure/stroke volume index is associated with impaired outcome in hypertensive patients with left ventricular hypertrophy the LIFE study

LBOS 01-04 THE TRUE INCIDENCE OF STATIN -RELATED ADVERSE EVENTS IN HYPERTENSIVE PATIENTS REVEALED BY COMPARISON OF BLINDED AND UN-BLINDED USE OF STATIN IN THE ANGLO-SCANDINAVIAN CARDIAC OUTCOMES TRIAL (ASCOT)

Angiotensin AT2-receptor stimulation improves survival and neurological outcome after experimental stroke in mice

Cardiovascular Outcomes According to Systolic Blood Pressure in Patients With and Without Diabetes: An ACCOMPLISH Substudy

Physical activity and exercise lower blood pressure in individuals with hypertension: narrative review of 27 RCTs

Blood pressure variability predicts cardiovascular events independently of traditional cardiovascular risk factors and target organ damage: a LIFE substudy

Aerobic physical activity lowers blood pressure in hypertension

Left Ventricular Wall Stress-Mass-Heart Rate Product and Cardiovascular Events in Treated Hypertensive Patients: LIFE Study

Effect of Lower On-Treatment Systolic Blood Pressure on the Risk of Atrial Fibrillation in Hypertensive Patients

Digoxin use and risk of mortality in hypertensive patients with atrial fibrillation

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