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Insulin-Degrading Enzyme, an Under-Estimated Potential Target to Treat Cancer?

Cells (Basel, Switzerland), 2022-04, Vol.11 (7), p.1228

2022

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The French Medicinal Chemistry Society–SCT, an Historical Member of EFMC

ChemMedChem, 2024-10, Vol.19 (19), p.e202400437-n/a

2024

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Catalytic site inhibition of insulin-degrading enzyme by a small molecule induces glucose intolerance in mice

Nature communications, 2015-09, Vol.6 (1), p.8250-8250, Article 8250

2015

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Insulin‐degrading enzyme inhibition increases the unfolded protein response and favours lipid accumulation in the liver

British journal of pharmacology, 2024-10, Vol.181 (19), p.3610-3626

2024

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Synthetic EthR inhibitors boost antituberculous activity of ethionamide

Nature Medicine, 2009-05, Vol.15 (5), p.537-544

2009

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Controlling Plasma Stability of Hydroxamic Acids: A MedChem Toolbox

Journal of medicinal chemistry, 2017-11, Vol.60 (21), p.9067-9089

2017

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A library of novel hydroxamic acids targeting the metallo-protease family: Design, parallel synthesis and screening

Bioorganic & medicinal chemistry, 2007, Vol.15 (1), p.63-76

2007

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Discovery of the First Selective Nanomolar Inhibitors of ERAP2 by Kinetic Target‐Guided Synthesis

Angewandte Chemie International Edition, 2022-09, Vol.61 (39), p.e202203560-n/a

International ed. in English, 2022

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Modulators of hERAP2 discovered by high-throughput screening

European journal of medicinal chemistry, 2021-02, Vol.211, p.113053, Article 113053

2021

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Efficient propylphosphonic anhydride (®T3P) mediated synthesis of benzothiazoles, benzoxazoles and benzimidazoles

Tetrahedron letters, 2012-05, Vol.53 (19), p.2440-2443

2012

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Structure–activity relationships of imidazole-derived 2-[N-carbamoylmethyl-alkylamino]acetic acids, dual binders of human insulin-degrading enzyme

European journal of medicinal chemistry, 2015-01, Vol.90 (C), p.547-567

2015

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Synthesis, Antimalarial Activity, and Molecular Modeling of New Pyrrolo[1,2-a]quinoxalines, Bispyrrolo[1,2-a]quinoxalines, Bispyrido[3,2-e]pyrrolo[1,2-a]pyrazines, and Bispyrrolo[1,2-a]thieno[3,2-e]pyrazines

Journal of medicinal chemistry, 2004-04, Vol.47 (8), p.1997-2009

2004

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Alkylsquarates as key intermediates for the rapid preparation of original drug-inspired compounds

Combinatorial chemistry & high throughput screening, 2008-05, Vol.11 (4), p.294-303

2008

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Synthesis of a 200-member library of squaric acid N-hydroxylamide amides

Bioorganic & medicinal chemistry letters, 2008-09, Vol.18 (18), p.4968-4971

2008

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Natural Compounds: Leads or Ideas? Bioinspired Molecules for Drug Discovery

Chemical biology & drug design, 2008-07, Vol.72 (1), p.3-15

2008

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Kinetic Target-Guided Synthesis: Reaching the Age of Maturity

Journal of medicinal chemistry, 2020-04, Vol.63 (8), p.3817-3833

2020

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Molecular Design in Practice: A Review of Selected Projects in a French Research Institute That Illustrates the Link between Chemical Biology and Medicinal Chemistry

Molecules (Basel, Switzerland), 2021-10, Vol.26 (19), p.6083

2021

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Novel Selective Inhibitors of the Zinc Plasmodial Aminopeptidase PfA-M1 as Potential Antimalarial Agents

Journal of medicinal chemistry, 2007-03, Vol.50 (6), p.1322-1334

2007

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Kinetic target-guided synthesis in drug discovery and chemical biology: a comprehensive facts and figures survey

Future medicinal chemistry, 2016-03, Vol.8 (4), p.381-404

2016

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Ensemble cryoEM elucidates the mechanism of insulin capture and degradation by human insulin degrading enzyme

eLife, 2018-03, Vol.7 (3, 2018)

2018

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Hydroxamates: Relationships between Structure and Plasma Stability

Journal of medicinal chemistry, 2009-11, Vol.52 (21), p.6790-6802

2009

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ADAMTS5 promotes murine adipogenesis and visceral adipose tissue expansion

Thrombosis and haemostasis, 2016-10, Vol.116 (4), p.694-704

2016

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Structure–Activity Relationships and Blood Distribution of Antiplasmodial Aminopeptidase‑1 Inhibitors

Journal of medicinal chemistry, 2012-12, Vol.55 (24), p.10909-10917

2012

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Design, synthesis and antimalarial activity of novel, quinoline-Based, zinc metallo-aminopeptidase inhibitors

Bioorganic & medicinal chemistry letters, 2003-08, Vol.13 (16), p.2659-2662

2003

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Insulin-Degrading Enzyme, an Under-Estimated Potential Target to Treat Cancer?

The French Medicinal Chemistry Society–SCT, an Historical Member of EFMC

Catalytic site inhibition of insulin-degrading enzyme by a small molecule induces glucose intolerance in mice

Insulin‐degrading enzyme inhibition increases the unfolded protein response and favours lipid accumulation in the liver

Synthetic EthR inhibitors boost antituberculous activity of ethionamide

Controlling Plasma Stability of Hydroxamic Acids: A MedChem Toolbox

A library of novel hydroxamic acids targeting the metallo-protease family: Design, parallel synthesis and screening

Discovery of the First Selective Nanomolar Inhibitors of ERAP2 by Kinetic Target‐Guided Synthesis

Modulators of hERAP2 discovered by high-throughput screening

Efficient propylphosphonic anhydride (®T3P) mediated synthesis of benzothiazoles, benzoxazoles and benzimidazoles

Structure–activity relationships of imidazole-derived 2-[N-carbamoylmethyl-alkylamino]acetic acids, dual binders of human insulin-degrading enzyme

Synthesis, Antimalarial Activity, and Molecular Modeling of New Pyrrolo[1,2-a]quinoxalines, Bispyrrolo[1,2-a]quinoxalines, Bispyrido[3,2-e]pyrrolo[1,2-a]pyrazines, and Bispyrrolo[1,2-a]thieno[3,2-e]pyrazines

Alkylsquarates as key intermediates for the rapid preparation of original drug-inspired compounds

Synthesis of a 200-member library of squaric acid N-hydroxylamide amides

Natural Compounds: Leads or Ideas? Bioinspired Molecules for Drug Discovery

Kinetic Target-Guided Synthesis: Reaching the Age of Maturity

Molecular Design in Practice: A Review of Selected Projects in a French Research Institute That Illustrates the Link between Chemical Biology and Medicinal Chemistry

Novel Selective Inhibitors of the Zinc Plasmodial Aminopeptidase PfA-M1 as Potential Antimalarial Agents

Kinetic target-guided synthesis in drug discovery and chemical biology: a comprehensive facts and figures survey

Ensemble cryoEM elucidates the mechanism of insulin capture and degradation by human insulin degrading enzyme

ADAM30 Downregulates APP-Linked Defects Through Cathepsin D Activation in Alzheimer's Disease

Hydroxamates: Relationships between Structure and Plasma Stability

ADAMTS5 promotes murine adipogenesis and visceral adipose tissue expansion

Structure–Activity Relationships and Blood Distribution of Antiplasmodial Aminopeptidase‑1 Inhibitors

Design, synthesis and antimalarial activity of novel, quinoline-Based, zinc metallo-aminopeptidase inhibitors

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