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FTY720 (Fingolimod) Inhibits HIF1 and HIF2 Signaling, Promotes Vascular Remodeling, and Chemosensitizes in Renal Cell Carcinoma Animal Model

Molecular cancer therapeutics, 2016-10, Vol.15 (10), p.2465-2474

2016

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Downregulating sphingosine kinase-1 for cancer therapy

Expert opinion on therapeutic targets, 2008-08, Vol.12 (8), p.1009-1020

Cuvillier, Olivier

2008

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Increased phospholipase D activity contributes to tumorigenesis in prostate cancer cell models

Molecular and cellular biochemistry, 2020-10, Vol.473 (1-2), p.263-279

2020

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When the Sphingosine Kinase 1/Sphingosine 1-Phosphate Pathway Meets Hypoxia Signaling: New Targets for Cancer Therapy

Cancer research (Chicago, Ill.), 2009-05, Vol.69 (9), p.3723-3726

2009

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First evidence of sphingosine 1-phosphate lyase protein expression and activity downregulation in human neoplasm: implication for resistance to therapeutics in prostate cancer

Molecular cancer therapeutics, 2012-09, Vol.11 (9), p.1841-1851

2012

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N -Heterocyclic Carbene-Iridium Complexes as Photosensitizers for In Vitro Photodynamic Therapy to Trigger Non-Apoptotic Cell Death in Cancer Cells

Molecules (Basel, Switzerland), 2023-01, Vol.28 (2), p.691

2023

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FTY720 (Fingolimod) Sensitizes Prostate Cancer Cells to Radiotherapy by Inhibition of Sphingosine Kinase-1

Cancer research (Chicago, Ill.), 2010-11, Vol.70 (21), p.8651-8661

2010

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sphingosine kinase-1 survival pathway is a molecular target for the tumor-suppressive tea and wine polyphenols in prostate cancer

The FASEB journal, 2010-10, Vol.24 (10), p.3882-3894

2010

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Development and characterization of sphingosine 1-phosphate receptor 1 monoclonal antibody suitable for cell imaging and biochemical studies of endogenous receptors

PloS one, 2019-03, Vol.14 (3), p.e0213203-e0213203

2019

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Sphingosine 1-Phosphate Receptor 5 (S1P5) Deficiency Promotes Proliferation and Immortalization of Mouse Embryonic Fibroblasts

Cancers, 2022-03, Vol.14 (7), p.1661

2022

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Pharmacological Characterization of [18F]-FNM and Evaluation of NMDA Receptors Activation in a Rat Brain Injury Model

Molecular imaging and biology, 2023-08, Vol.25 (4), p.692-703

2023

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Hypoxia-inducible factors and sphingosine 1-phosphate signaling

Anti-cancer agents in medicinal chemistry, 2011-11, Vol.11 (9), p.854

2011

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Gem GTPase acts upstream Gmip/RhoA to regulate cortical actin remodeling and spindle positioning during early mitosis

Carcinogenesis (New York), 2014-11, Vol.35 (11), p.2503-2511

2014

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Synthesis of fluorinated agonist of sphingosine-1-phosphate receptor 1

Bioorganic & medicinal chemistry, 2014-09, Vol.22 (17), p.4955-4960

2014

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Oxidative Stress–Dependent Sphingosine Kinase-1 Inhibition Mediates Monoamine Oxidase A–Associated Cardiac Cell Apoptosis

Circulation research, 2007-01, Vol.100 (1), p.41-49

2007

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Osteoblast-derived sphingosine 1-phosphate to induce proliferation and confer resistance to therapeutics to bone metastasis-derived prostate cancer cells

Molecular oncology, 2014-10, Vol.8 (7), p.1181-1195

2014

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Reduced sphingosine kinase-1 and enhanced sphingosine 1-phosphate lyase expression demonstrate deregulated sphingosine 1-phosphate signaling in Alzheimer's disease

Acta neuropathologica communications, 2014-01, Vol.2 (1), p.12-12, Article 12

2014

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Sphingosine kinase-1 as a chemotherapy sensor in prostate adenocarcinoma cell and mouse models

Cancer research (Chicago, Ill.), 2005-12, Vol.65 (24), p.11667-11675

2005

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Sphingosine kinase-1 activity and expression in human prostate cancer resection specimens

European journal of cancer (1990), 2010-12, Vol.46 (18), p.3417-3424

2010

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Hypoxia, Therapeutic Resistance, and Sphingosine 1-Phosphate

Advances in Cancer Research, 2013, Vol.117, p.117-141

2013

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Targeting the sphingolipid metabolism to defeat pancreatic cancer cell resistance to the chemotherapeutic gemcitabine drug

Molecular cancer therapeutics, 2009-04, Vol.8 (4), p.809-820

2009

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Biochemical methods for quantifying sphingolipids: ceramide, sphingosine, sphingosine kinase-1 activity, and sphingosine-1-phosphate

Methods in molecular biology (Clifton, N.J.), 2012, Vol.874, p.1

2012

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Neuronal sphingosine kinase 2 subcellular localization is altered in Alzheimer's disease brain

Acta neuropathologica communications, 2018-04, Vol.6 (1), p.25-25, Article 25

2018

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Chemosensitizing effects of sphingosine kinase-1 inhibition in prostate cancer cell and animal models

Molecular cancer therapeutics, 2008-07, Vol.7 (7), p.1836-1845

2008

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Sphingosine 1-phosphate antagonizes apoptosis of human leukemia cells by inhibiting release of cytochrome c and Smac/DIABLO from mitochondria

Blood, 2001-11, Vol.98 (9), p.2828-2836

2001

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FTY720 (Fingolimod) Inhibits HIF1 and HIF2 Signaling, Promotes Vascular Remodeling, and Chemosensitizes in Renal Cell Carcinoma Animal Model

Downregulating sphingosine kinase-1 for cancer therapy

Increased phospholipase D activity contributes to tumorigenesis in prostate cancer cell models

When the Sphingosine Kinase 1/Sphingosine 1-Phosphate Pathway Meets Hypoxia Signaling: New Targets for Cancer Therapy

First evidence of sphingosine 1-phosphate lyase protein expression and activity downregulation in human neoplasm: implication for resistance to therapeutics in prostate cancer

N -Heterocyclic Carbene-Iridium Complexes as Photosensitizers for In Vitro Photodynamic Therapy to Trigger Non-Apoptotic Cell Death in Cancer Cells

FTY720 (Fingolimod) Sensitizes Prostate Cancer Cells to Radiotherapy by Inhibition of Sphingosine Kinase-1

sphingosine kinase-1 survival pathway is a molecular target for the tumor-suppressive tea and wine polyphenols in prostate cancer

Development and characterization of sphingosine 1-phosphate receptor 1 monoclonal antibody suitable for cell imaging and biochemical studies of endogenous receptors

Sphingosine 1-Phosphate Receptor 5 (S1P5) Deficiency Promotes Proliferation and Immortalization of Mouse Embryonic Fibroblasts

Pharmacological Characterization of [18F]-FNM and Evaluation of NMDA Receptors Activation in a Rat Brain Injury Model

Hypoxia-inducible factors and sphingosine 1-phosphate signaling

Gem GTPase acts upstream Gmip/RhoA to regulate cortical actin remodeling and spindle positioning during early mitosis

Synthesis of fluorinated agonist of sphingosine-1-phosphate receptor 1

Oxidative Stress–Dependent Sphingosine Kinase-1 Inhibition Mediates Monoamine Oxidase A–Associated Cardiac Cell Apoptosis

Osteoblast-derived sphingosine 1-phosphate to induce proliferation and confer resistance to therapeutics to bone metastasis-derived prostate cancer cells

Reduced sphingosine kinase-1 and enhanced sphingosine 1-phosphate lyase expression demonstrate deregulated sphingosine 1-phosphate signaling in Alzheimer's disease

Sphingosine kinase-1 as a chemotherapy sensor in prostate adenocarcinoma cell and mouse models

Sphingosine kinase-1 activity and expression in human prostate cancer resection specimens

Hypoxia, Therapeutic Resistance, and Sphingosine 1-Phosphate

Targeting the sphingolipid metabolism to defeat pancreatic cancer cell resistance to the chemotherapeutic gemcitabine drug

Biochemical methods for quantifying sphingolipids: ceramide, sphingosine, sphingosine kinase-1 activity, and sphingosine-1-phosphate

Neuronal sphingosine kinase 2 subcellular localization is altered in Alzheimer's disease brain

Chemosensitizing effects of sphingosine kinase-1 inhibition in prostate cancer cell and animal models

Sphingosine 1-phosphate antagonizes apoptosis of human leukemia cells by inhibiting release of cytochrome c and Smac/DIABLO from mitochondria

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