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Selective depletion of uropathogenic E. coli from the gut by a FimH antagonist

Nature (London), 2017-06, Vol.546 (7659), p.528-532

2017

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Citrulline Protects Streptococcus pyogenes from Acid Stress Using the Arginine Deiminase Pathway and the F₁Fₒ-ATPase

Journal of bacteriology, 2015-04, Vol.197 (7), p.1288-1296

2015

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Cancer immunotherapy by NC410, a LAIR-2 Fc protein blocking human LAIR-collagen interaction

eLife, 2021-06, Vol.10

2021

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Streptococcus pyogenes Arginine and Citrulline Catabolism Promotes Infection and Modulates Innate Immunity

Infection and Immunity, 2014-01, Vol.82 (1), p.233-242

2014

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Mannose-derived FimH antagonists: a promising anti-virulence therapeutic strategy for urinary tract infections and Crohn's disease

Expert opinion on therapeutic patents, 2016-02, Vol.26 (2), p.175-197

2016

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Development of an immunohistochemical assay for Siglec-15

Laboratory investigation, 2022-07, Vol.102 (7), p.771-778

2022

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Structure-Function Analysis of the Curli Accessory Protein CsgE Defines Surfaces Essential for Coordinating Amyloid Fiber Formation

mBio, 2018-07, Vol.9 (4)

2018

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Solution NMR structure of CsgE: Structural insights into a chaperone and regulator protein important for functional amyloid formation

Proceedings of the National Academy of Sciences - PNAS, 2016-06, Vol.113 (26), p.7130-7135

2016

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SpxA1 and SpxA2 Act Coordinately To Fine-Tune Stress Responses and Virulence in Streptococcus pyogenes

mBio, 2017-03, Vol.8 (2)

2017

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Adaptive Evolution of the Streptococcus pyogenes Regulatory Aldolase LacD.1

Journal of Bacteriology, 2013-03, Vol.195 (6), p.1294-1304

2013

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Host and bacterial proteases influence biofilm formation and virulence in a murine model of enterococcal catheter-associated urinary tract infection

NPJ biofilms and microbiomes, 2017-11, Vol.3 (1), p.28-12, Article 28

2017

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570 Blockade of the inhibitory collagen receptor LAIR-1, PD-L1, and TGF-β promotes anti-tumor activity through T cell activation and myeloid cell polarization

Journal for immunotherapy of cancer, 2021-11, Vol.9 (Suppl 2), p.A599-A599

2021

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490 Clinical benefit through Siglec-15 targeting with NC318 antibody in subjects with Siglec-15 positive advanced solid tumors

Journal for immunotherapy of cancer, 2021-11, Vol.9 (Suppl 2), p.A520-A521

2021

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Innovative Solutions to Sticky Situations: Antiadhesive Strategies for Treating Bacterial Infections

Microbiology spectrum, 2016-04, Vol.4 (2)

2016

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694 NC410 is a novel immunomedicine for the treatment of solid tumors

Journal for immunotherapy of cancer, 2020-11, Vol.8 (Suppl 3), p.A736-A736

2020

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Antivirulence C‑Mannosides as Antibiotic-Sparing, Oral Therapeutics for Urinary Tract Infections

Journal of medicinal chemistry, 2016-10, Vol.59 (20), p.9390-9408

2016

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Citrulline Protects Streptococcus pyogenes from Acid Stress Using the Arginine Deiminase Pathway and the F^sub 1^F^sub o^-ATPase

Journal of bacteriology, 2015-04, Vol.197 (7), p.1288

2015

Volltextzugriff (PDF)

Citrulline Protects Streptococcus pyogenes from Acid Stress Using the Arginine Deiminase Pathway and the F 1 F o -ATPase

Journal of bacteriology, 2015-04, Vol.197 (7), p.1288-1296

2015

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Antivirulence Isoquinolone Mannosides: Optimization of the Biaryl Aglycone for FimH Lectin Binding Affinity and Efficacy in the Treatment of Chronic UTI

ChemMedChem, 2016-02, Vol.11 (4), p.367-373

2016

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A Phase 1, Open-Label, Safety, Tolerability, and Efficacy Study of NC525 in Subjects with Advanced Myeloid Neoplasms

Blood, 2022-11, Vol.140 (Supplement 1), p.9078-9079

2022

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Enhancement of antimicrobial activity by synthetic ion channel synergy

Chemical communications (Cambridge, England), 2010-11, Vol.46 (43), p.8166-8167

2010

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The FLRT3-UNC5B checkpoint pathway inhibits T cell-based cancer immunotherapies

Science advances, 2024-03, Vol.10 (9), p.eadj4698-eadj4698

2024

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739 A phase 1b/2, open-label, safety, tolerability and efficacy study of NC410 plus pembrolizumab for participants with immune checkpoint inhibitor (ICI) refractory, or MSS/MSI-low ICI naïve advanced or metastatic solid tumors

Journal for immunotherapy of cancer, 2022-11, Vol.10 (Suppl 2), p.A772-A772

2022

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748 A phase 1/2, open-label, dose-escalation, safety and tolerability study of NC762 in subjects with advanced or metastatic solid tumors

Journal for immunotherapy of cancer, 2022-11, Vol.10 (Suppl 2), p.A781-A781

2022

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Hydraphiles enhance antimicrobial potency against Escherichia coli, Pseudomonas aeruginosa, and Bacillus subtilis

Bioorganic & medicinal chemistry, 2016-06, Vol.24 (12), p.2864-2870

2016

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Selective depletion of uropathogenic E. coli from the gut by a FimH antagonist

Citrulline Protects Streptococcus pyogenes from Acid Stress Using the Arginine Deiminase Pathway and the F₁Fₒ-ATPase

Cancer immunotherapy by NC410, a LAIR-2 Fc protein blocking human LAIR-collagen interaction

Streptococcus pyogenes Arginine and Citrulline Catabolism Promotes Infection and Modulates Innate Immunity

Mannose-derived FimH antagonists: a promising anti-virulence therapeutic strategy for urinary tract infections and Crohn's disease

Development of an immunohistochemical assay for Siglec-15

Structure-Function Analysis of the Curli Accessory Protein CsgE Defines Surfaces Essential for Coordinating Amyloid Fiber Formation

Solution NMR structure of CsgE: Structural insights into a chaperone and regulator protein important for functional amyloid formation

SpxA1 and SpxA2 Act Coordinately To Fine-Tune Stress Responses and Virulence in Streptococcus pyogenes

Adaptive Evolution of the Streptococcus pyogenes Regulatory Aldolase LacD.1

Host and bacterial proteases influence biofilm formation and virulence in a murine model of enterococcal catheter-associated urinary tract infection

570 Blockade of the inhibitory collagen receptor LAIR-1, PD-L1, and TGF-β promotes anti-tumor activity through T cell activation and myeloid cell polarization

490 Clinical benefit through Siglec-15 targeting with NC318 antibody in subjects with Siglec-15 positive advanced solid tumors

Innovative Solutions to Sticky Situations: Antiadhesive Strategies for Treating Bacterial Infections

694 NC410 is a novel immunomedicine for the treatment of solid tumors

Antivirulence C‑Mannosides as Antibiotic-Sparing, Oral Therapeutics for Urinary Tract Infections

Citrulline Protects Streptococcus pyogenes from Acid Stress Using the Arginine Deiminase Pathway and the F^sub 1^F^sub o^-ATPase

Citrulline Protects Streptococcus pyogenes from Acid Stress Using the Arginine Deiminase Pathway and the F 1 F o -ATPase

Antivirulence Isoquinolone Mannosides: Optimization of the Biaryl Aglycone for FimH Lectin Binding Affinity and Efficacy in the Treatment of Chronic UTI

A Phase 1, Open-Label, Safety, Tolerability, and Efficacy Study of NC525 in Subjects with Advanced Myeloid Neoplasms

Enhancement of antimicrobial activity by synthetic ion channel synergy

The FLRT3-UNC5B checkpoint pathway inhibits T cell-based cancer immunotherapies

739 A phase 1b/2, open-label, safety, tolerability and efficacy study of NC410 plus pembrolizumab for participants with immune checkpoint inhibitor (ICI) refractory, or MSS/MSI-low ICI naïve advanced or metastatic solid tumors

748 A phase 1/2, open-label, dose-escalation, safety and tolerability study of NC762 in subjects with advanced or metastatic solid tumors

Hydraphiles enhance antimicrobial potency against Escherichia coli, Pseudomonas aeruginosa, and Bacillus subtilis

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