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Discovery of Thieno[3,2‑d]pyrimidine-6-carboxamides as Potent Inhibitors of SIRT1, SIRT2, and SIRT3

Journal of medicinal chemistry, 2013-05, Vol.56 (9), p.3666-3679

2013

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Encoded Library Synthesis Using Chemical Ligation and the Discovery of sEH Inhibitors from a 334-Million Member Library

Scientific reports, 2015-06, Vol.5 (1), p.10916-10916, Article 10916

2015

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Application of encoded library technology (ELT) to a protein–protein interaction target: Discovery of a potent class of integrin lymphocyte function-associated antigen 1 (LFA-1) antagonists

Bioorganic & medicinal chemistry, 2014-04, Vol.22 (7), p.2353-2365

2014

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Pathways for protein disulphide bond formation

Trends in cell biology, 2000-05, Vol.10 (5), p.203-210

2000

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Competition between glutathione and protein thiols for disulphide-bond formation

Nature cell biology, 1999-07, Vol.1 (3), p.130-135

1999

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Novel Autotaxin Inhibitor for the Treatment of Idiopathic Pulmonary Fibrosis: A Clinical Candidate Discovered Using DNA-Encoded Chemistry

Journal of medicinal chemistry, 2020-07, Vol.63 (14), p.7840-7856

2020

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Machine Learning on DNA-Encoded Libraries: A New Paradigm for Hit Finding

Journal of medicinal chemistry, 2020-08, Vol.63 (16), p.8857-8866

2020

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A flavoprotein oxidase defines a new endoplasmic reticulum pathway for biosynthetic disulphide bond formation

Nature cell biology, 2001-10, Vol.3 (10), p.874-882

2001

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Discovery of a Potent BTK Inhibitor with a Novel Binding Mode by Using Parallel Selections with a DNA‐Encoded Chemical Library

Chembiochem : a European journal of chemical biology, 2017-05, Vol.18 (9), p.864-871

2017

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Bispecific Estrogen Receptor α Degraders Incorporating Novel Binders Identified Using DNA-Encoded Chemical Library Screening

Journal of medicinal chemistry, 2021-04, Vol.64 (8), p.5049-5066

2021

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Discovery of a First-in-Class Small-Molecule Ligand for WDR91 Using DNA-Encoded Chemical Library Selection Followed by Machine Learning

Journal of medicinal chemistry, 2023-12, Vol.66 (23), p.16051-16061

2023

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Novel irreversible covalent BTK inhibitors discovered using DNA-encoded chemistry

Bioorganic & medicinal chemistry, 2021-07, Vol.42, p.116223-116223, Article 116223

2021

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Discovery of Novel UDP‑N‑Acetylglucosamine Acyltransferase (LpxA) Inhibitors with Activity against Pseudomonas aeruginosa

Journal of medicinal chemistry, 2021-10, Vol.64 (19), p.14377-14425

2021

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Discovery of cofactor-specific, bactericidal Mycobacterium tuberculosis InhA inhibitors using DNA-encoded library technology

Proceedings of the National Academy of Sciences - PNAS, 2016-12, Vol.113 (49), p.E7880-E7889

2016

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Discovery of Novel, Potent Inhibitors of Hydroxy Acid Oxidase 1 (HAO1) Using DNA-Encoded Chemical Library Screening

Journal of medicinal chemistry, 2021-05, Vol.64 (10), p.6730-6744

2021

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Phosphorylation of Threonine 290 in the Activation Loop of Tpl2/Cot Is Necessary but Not Sufficient for Kinase Activity

The Journal of biological chemistry, 2004-12, Vol.279 (50), p.52117-52123

2004

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Structure Based Design of Non-Natural Peptidic Macrocyclic Mcl‑1 Inhibitors

ACS medicinal chemistry letters, 2017-02, Vol.8 (2), p.239-244

2017

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Discovery of Potent and Selective Inhibitors for ADAMTS‑4 through DNA-Encoded Library Technology (ELT)

ACS medicinal chemistry letters, 2015-08, Vol.6 (8), p.888-893

2015

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Identification of a Novel Human Kinase Supporter of Ras (hKSR-2) That Functions as a Negative Regulator of Cot (Tpl2) Signaling

The Journal of biological chemistry, 2003-11, Vol.278 (47), p.47089-47097

2003

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Discovery of 2,4‑1H‑Imidazole Carboxamides as Potent and Selective TAK1 Inhibitors

ACS medicinal chemistry letters, 2021-04, Vol.12 (4), p.555-562

2021

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Discovery of Thieno[3,2‑d]pyrimidine-6-carboxamides as Potent Inhibitors of SIRT1, SIRT2, and SIRT3

Encoded Library Synthesis Using Chemical Ligation and the Discovery of sEH Inhibitors from a 334-Million Member Library

Application of encoded library technology (ELT) to a protein–protein interaction target: Discovery of a potent class of integrin lymphocyte function-associated antigen 1 (LFA-1) antagonists

Pathways for protein disulphide bond formation

Competition between glutathione and protein thiols for disulphide-bond formation

Novel Autotaxin Inhibitor for the Treatment of Idiopathic Pulmonary Fibrosis: A Clinical Candidate Discovered Using DNA-Encoded Chemistry

Machine Learning on DNA-Encoded Libraries: A New Paradigm for Hit Finding

A flavoprotein oxidase defines a new endoplasmic reticulum pathway for biosynthetic disulphide bond formation

Discovery of Nanomolar DCAF1 Small Molecule Ligands

Discovery of a Potent BTK Inhibitor with a Novel Binding Mode by Using Parallel Selections with a DNA‐Encoded Chemical Library

Bispecific Estrogen Receptor α Degraders Incorporating Novel Binders Identified Using DNA-Encoded Chemical Library Screening

Design, synthesis and selection of DNA-encoded small-molecule libraries

Discovery of a First-in-Class Small-Molecule Ligand for WDR91 Using DNA-Encoded Chemical Library Selection Followed by Machine Learning

Novel irreversible covalent BTK inhibitors discovered using DNA-encoded chemistry

Development of Potent Mcl‑1 Inhibitors: Structural Investigations on Macrocycles Originating from a DNA-Encoded Chemical Library Screen

Discovery of Novel UDP‑N‑Acetylglucosamine Acyltransferase (LpxA) Inhibitors with Activity against Pseudomonas aeruginosa

Discovery of cofactor-specific, bactericidal Mycobacterium tuberculosis InhA inhibitors using DNA-encoded library technology

Discovery of Novel, Potent Inhibitors of Hydroxy Acid Oxidase 1 (HAO1) Using DNA-Encoded Chemical Library Screening

Discovery of Highly Potent and Selective Small Molecule ADAMTS‑5 Inhibitors That Inhibit Human Cartilage Degradation via Encoded Library Technology (ELT)

Isoform-Selective ATAD2 Chemical Probe with Novel Chemical Structure and Unusual Mode of Action

Phosphorylation of Threonine 290 in the Activation Loop of Tpl2/Cot Is Necessary but Not Sufficient for Kinase Activity

Structure Based Design of Non-Natural Peptidic Macrocyclic Mcl‑1 Inhibitors

Discovery of Potent and Selective Inhibitors for ADAMTS‑4 through DNA-Encoded Library Technology (ELT)

Identification of a Novel Human Kinase Supporter of Ras (hKSR-2) That Functions as a Negative Regulator of Cot (Tpl2) Signaling

Discovery of 2,4‑1H‑Imidazole Carboxamides as Potent and Selective TAK1 Inhibitors

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