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DNA stretching induces Cas9 off-target activity

Nature structural & molecular biology, 2019-03, Vol.26 (3), p.185-192

2019

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CRISPR GUARD protects off-target sites from Cas9 nuclease activity using short guide RNAs

Nature communications, 2020-08, Vol.11 (1), p.4132-12, Article 4132

2020

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Antitumor Activity of Osimertinib, an Irreversible Mutant-Selective EGFR Tyrosine Kinase Inhibitor, in NSCLC Harboring EGFR Exon 20 Insertions

Molecular cancer therapeutics, 2018-05, Vol.17 (5), p.885-896

2018

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Drug Sensitivity and Allele Specificity of First-Line Osimertinib Resistance EGFR Mutations

Cancer research (Chicago, Ill.), 2020-05, Vol.80 (10), p.2017-2030

2020

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BE-FLARE: a fluorescent reporter of base editing activity reveals editing characteristics of APOBEC3A and APOBEC3B

BMC biology, 2018-12, Vol.16 (1), p.150-150, Article 150

2018

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Screening for molecular glues – Challenges and opportunities

SLAS discovery, 2024-03, Vol.29 (2), p.100136-100136, Article 100136

2024

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p53-Driven apoptosis limits centrosome amplification and genomic instability downstream of NPM1 phosphorylation

Nature cell biology, 2008-06, Vol.10 (6), p.723-730

2008

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Mechanism-based screen establishes signalling framework for DNA damage-associated G1 checkpoint response

PloS one, 2012-02, Vol.7 (2), p.e31627-e31627

2012

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Cas12a target search and cleavage on force stretched DNA

Biophysical journal, 2022-02, Vol.121 (3), p.288a-288a

2022

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Overcoming Osimertinib Resistance with AKT Inhibition in EGFRm-Driven Non–Small Cell Lung Cancer with PIK3CA/PTEN Alterations

Clinical cancer research, 2024-09, Vol.30 (18), p.4143-4154

2024

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Cas12a target search and cleavage on force-stretched DNA

Physical chemistry chemical physics : PCCP, 2021-12, Vol.23 (47), p.2664-26644

2021

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Negative DNA supercoiling induces genome-wide Cas9 off-target activity

Molecular cell, 2023-10, Vol.83 (19), p.3533-3545.e5

2023

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Drug Sensitivity and Allele‐specificity of First‐line Osimertinib Resistance EGFR Mutations

The FASEB journal, 2020-04, Vol.34 (S1), p.1-1

2020

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CRISPR/Cas9 On- and Off-Target Activity Using Correlative Force and Fluorescence Single-Molecule Microscopy

Methods in molecular biology (Clifton, N.J.), 2022, Vol.2478, p.349

2022

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Anti-tumor activity of osimertinib, an irreversible mutant-selective EGFR tyrosine kinase inhibitor, in NSCLC harboring EGFR Exon 20 Insertions

Molecular cancer therapeutics, 2018-02, Vol.17 (5), p.885-896

2018

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Abstract 2079: Osimertinib, an irreversible mutant selective EGFR tyrosine kinase inhibitor, exerts anti tumor activity in NSCLC harbouring exon 20 insertion mutant-EGFR

Cancer research (Chicago, Ill.), 2017-07, Vol.77 (13_Supplement), p.2079-2079

2017

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Antitumor activity of osimertinib in NSCLC harboring EGFR exon 20 insertions

Journal of clinical oncology, 2017-05, Vol.35 (15_suppl), p.9030-9030

2017

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Developing an Arrayed CRISPR-Cas9 Co-Culture Screen for Immuno-Oncology Target ID

SLAS discovery, 2020-07, Vol.25 (6), p.581-590

2020

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Cyclin-Cyclin-dependent Kinase Regulatory Response Is Linked to Substrate Recognition

The Journal of biological chemistry, 2011-03, Vol.286 (11), p.9713-9725

2011

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Regulation of Microfilament Organization by Kaposi Sarcoma-associated Herpes Virus-cyclin·CDK6 Phosphorylation of Caldesmon

The Journal of biological chemistry, 2005-10, Vol.280 (43), p.35844-35858

2005

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Regulation of microfilament organization by Kaposi sarcoma-associated herpes virus-cyclin.CDK6 phosphorylation of caldesmon

The Journal of biological chemistry, 2005-10, Vol.280 (43), p.35844-35858

2005

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Regulation of Microfilament Organization by Kaposi Sarcoma-associated Herpes Virus-cyclinÂ·CDK6 Phosphorylation of Caldesmon

The Journal of biological chemistry, 2005-10, Vol.280 (43), p.35844

2005

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Detection of the Human Herpesvirus 8-Encoded Cyclin Protein in Primary Effusion Lymphoma-Derived Cell Lines

Virology (New York, N.Y.), 2000-07, Vol.272 (2), p.257-266

2000

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Functional analysis of the cyclin encoded by kaposi's sarcoma herpes virus

Cuomo, Maria Emanuela

2002

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Negative DNA Supercoiling Induces Genome Wide Cas9 Off-Target Activity

SSRN Electronic Journal

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DNA stretching induces Cas9 off-target activity

CRISPR GUARD protects off-target sites from Cas9 nuclease activity using short guide RNAs

Antitumor Activity of Osimertinib, an Irreversible Mutant-Selective EGFR Tyrosine Kinase Inhibitor, in NSCLC Harboring EGFR Exon 20 Insertions

Drug Sensitivity and Allele Specificity of First-Line Osimertinib Resistance EGFR Mutations

BE-FLARE: a fluorescent reporter of base editing activity reveals editing characteristics of APOBEC3A and APOBEC3B

Screening for molecular glues – Challenges and opportunities

p53-Driven apoptosis limits centrosome amplification and genomic instability downstream of NPM1 phosphorylation

Mechanism-based screen establishes signalling framework for DNA damage-associated G1 checkpoint response

Cas12a target search and cleavage on force stretched DNA

Overcoming Osimertinib Resistance with AKT Inhibition in EGFRm-Driven Non–Small Cell Lung Cancer with PIK3CA/PTEN Alterations

Cas12a target search and cleavage on force-stretched DNA

Negative DNA supercoiling induces genome-wide Cas9 off-target activity

Drug Sensitivity and Allele‐specificity of First‐line Osimertinib Resistance EGFR Mutations

CRISPR/Cas9 On- and Off-Target Activity Using Correlative Force and Fluorescence Single-Molecule Microscopy

Anti-tumor activity of osimertinib, an irreversible mutant-selective EGFR tyrosine kinase inhibitor, in NSCLC harboring EGFR Exon 20 Insertions

Abstract 2079: Osimertinib, an irreversible mutant selective EGFR tyrosine kinase inhibitor, exerts anti tumor activity in NSCLC harbouring exon 20 insertion mutant-EGFR

Antitumor activity of osimertinib in NSCLC harboring EGFR exon 20 insertions

Developing an Arrayed CRISPR-Cas9 Co-Culture Screen for Immuno-Oncology Target ID

Cyclin-Cyclin-dependent Kinase Regulatory Response Is Linked to Substrate Recognition

Regulation of Microfilament Organization by Kaposi Sarcoma-associated Herpes Virus-cyclin·CDK6 Phosphorylation of Caldesmon

Regulation of microfilament organization by Kaposi sarcoma-associated herpes virus-cyclin.CDK6 phosphorylation of caldesmon

Regulation of Microfilament Organization by Kaposi Sarcoma-associated Herpes Virus-cyclinÂ·CDK6 Phosphorylation of Caldesmon

Detection of the Human Herpesvirus 8-Encoded Cyclin Protein in Primary Effusion Lymphoma-Derived Cell Lines

Functional analysis of the cyclin encoded by kaposi's sarcoma herpes virus

Negative DNA Supercoiling Induces Genome Wide Cas9 Off-Target Activity

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