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Dual Action of Antimonial Drugs on Thiol Redox Metabolism in the Human Pathogen Leishmania donovani

The Journal of biological chemistry, 2004-09, Vol.279 (38), p.39925-39932

2004

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Anthracimycin activity against contemporary methicillin-resistant Staphylococcus aureus

Journal of antibiotics, 2014-08, Vol.67 (8), p.549-553

2014

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Structure-Based Design of New Dihydrofolate Reductase Antibacterial Agents: 7‑(Benzimidazol-1-yl)-2,4-diaminoquinazolines

Journal of medicinal chemistry, 2014-02, Vol.57 (3), p.651-668

2014

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Down-Regulation of Leishmania donovani Trypanothione Reductase by Heterologous Expression of a Trans-Dominant Mutant Homologue: Effect on Parasite Intracellular Survival

Proceedings of the National Academy of Sciences - PNAS, 1998-04, Vol.95 (9), p.5311-5316

1998

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Pyrrolopyrimidine inhibitors of DNA gyrase B (GyrB) and topoisomerase IV (ParE). Part I: Structure guided discovery and optimization of dual targeting agents with potent, broad-spectrum enzymatic activity

Bioorganic & medicinal chemistry letters, 2013-03, Vol.23 (5), p.1529-1536

2013

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Tricyclic GyrB/ParE (TriBE) inhibitors: a new class of broad-spectrum dual-targeting antibacterial agents

PloS one, 2013-12, Vol.8 (12), p.e84409-e84409

2013

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Pyrrolopyrimidine inhibitors of DNA gyrase B (GyrB) and topoisomerase IV (ParE), Part II: Development of inhibitors with broad spectrum, Gram-negative antibacterial activity

Bioorganic & medicinal chemistry letters, 2013-03, Vol.23 (5), p.1537-1543

2013

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Identification of Bacteria-Selective Threonyl-tRNA Synthetase Substrate Inhibitors by Structure-Based Design

Journal of medicinal chemistry, 2013-02, Vol.56 (4), p.1748-1760

2013

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Characterization of quinonoid-Dihydropteridine Reductase (QDPR) from the Lower Eukaryote Leishmania major

The Journal of biological chemistry, 2002-10, Vol.277 (41), p.38245-38253

2002

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Distinguishing on-target versus off-target activity in early antibacterial drug discovery using a macromolecular synthesis assay

Journal of biomolecular screening, 2013-10, Vol.18 (9), p.1018-1026

2013

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Disruption of the trypanothione reductase gene of Leishmania decreases its ability to survive oxidative stress in macrophages

The EMBO journal, 1997-05, Vol.16 (10), p.2590-2598

1997

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Regulation of Differentiation to the Infective Stage of the Protozoan Parasite Leishmania major by Tetrahydrobiopterin

Science (American Association for the Advancement of Science), 2001-04, Vol.292 (5515), p.285-287

2001

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Crystal structure of Trypanosoma cruzi trypanothione reductase in complex with trypanothione, and the structure-based discovery of new natural product inhibitors

Structure (London), 1999-01, Vol.7 (1), p.81-89

1999

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The role of enzymology in a structure-based drug discovery program: bacterial DNA gyrase

Methods in molecular biology (Clifton, N.J.), 2012, Vol.841, p.179

Cunningham, Mark L

2012

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The Leishmania donovani LD1 locus gene ORFG encodes a biopterin transporter (BT1)

Molecular and biochemical parasitology, 1999-10, Vol.104 (1), p.93-105

1999

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Anti-plasmodial and anti-trypanosomal activity of synthetic naphtho[2,3- b]thiophen-4,9-quinones

Bioorganic & medicinal chemistry, 1997-12, Vol.5 (12), p.2185-2192

1997

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Pteridine salvage throughout the Leishmania infectious cycle: implications for antifolate chemotherapy

Molecular and biochemical parasitology, 2001-04, Vol.113 (2), p.199-213

2001

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The crystal structure of trypanothione reductase from the human pathogen Trypanosoma cruzi at 2.3 Å resolution

Protein science, 1996-01, Vol.5 (1), p.52-61

1996

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Trypanothione reductase from Leishmania donovani. Purification, characterisation and inhibition by trivalent antimonials

European journal of biochemistry, 1995-06, Vol.230 (2), p.460-468

1995

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Conservation of the LD1 region in Leishmania includes DNA implicated in LD1 amplification

Molecular and biochemical parasitology, 2001-04, Vol.113 (2), p.315-321

2001

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Mechanism of inhibition of trypanothione reductase and glutathione reductase by trivalent organic arsenicals

European journal of biochemistry, 1994-04, Vol.221 (1), p.285-295

1994

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Site‐Directed Mutagenesis of the Redox‐Active Cysteines of Trypanosoma cruzi Trypanothione Reductase

European journal of biochemistry, 1995-03, Vol.228 (3), p.745-752

1995

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Site-directed mutagenesis of the redox-active cysteines of Trypanosoma cruzi trypanothione reductase

European journal of biochemistry, 1995-03, Vol.228 (3), p.745-752

1995

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The management of terminally ill patients

Medical journal of Australia, 1992-11, Vol.157 (10), p.715-715

Cunningham, Mark L

1992

Volltextzugriff (PDF)

Trypanothione Reductase from Leishmania donovani

European journal of biochemistry, 1995-06, Vol.230 (2), p.460-468

1995

Volltextzugriff (PDF)

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Dual Action of Antimonial Drugs on Thiol Redox Metabolism in the Human Pathogen Leishmania donovani

Anthracimycin activity against contemporary methicillin-resistant Staphylococcus aureus

Structure-Based Design of New Dihydrofolate Reductase Antibacterial Agents: 7‑(Benzimidazol-1-yl)-2,4-diaminoquinazolines

Down-Regulation of Leishmania donovani Trypanothione Reductase by Heterologous Expression of a Trans-Dominant Mutant Homologue: Effect on Parasite Intracellular Survival

Pyrrolopyrimidine inhibitors of DNA gyrase B (GyrB) and topoisomerase IV (ParE). Part I: Structure guided discovery and optimization of dual targeting agents with potent, broad-spectrum enzymatic activity

Tricyclic GyrB/ParE (TriBE) inhibitors: a new class of broad-spectrum dual-targeting antibacterial agents

Pyrrolopyrimidine inhibitors of DNA gyrase B (GyrB) and topoisomerase IV (ParE), Part II: Development of inhibitors with broad spectrum, Gram-negative antibacterial activity

Identification of Bacteria-Selective Threonyl-tRNA Synthetase Substrate Inhibitors by Structure-Based Design

Characterization of quinonoid-Dihydropteridine Reductase (QDPR) from the Lower Eukaryote Leishmania major

Distinguishing on-target versus off-target activity in early antibacterial drug discovery using a macromolecular synthesis assay

Disruption of the trypanothione reductase gene of Leishmania decreases its ability to survive oxidative stress in macrophages

Regulation of Differentiation to the Infective Stage of the Protozoan Parasite Leishmania major by Tetrahydrobiopterin

Crystal structure of Trypanosoma cruzi trypanothione reductase in complex with trypanothione, and the structure-based discovery of new natural product inhibitors

The role of enzymology in a structure-based drug discovery program: bacterial DNA gyrase

The Leishmania donovani LD1 locus gene ORFG encodes a biopterin transporter (BT1)

Anti-plasmodial and anti-trypanosomal activity of synthetic naphtho[2,3- b]thiophen-4,9-quinones

Pteridine salvage throughout the Leishmania infectious cycle: implications for antifolate chemotherapy

The crystal structure of trypanothione reductase from the human pathogen Trypanosoma cruzi at 2.3 Å resolution

Trypanothione reductase from Leishmania donovani. Purification, characterisation and inhibition by trivalent antimonials

Conservation of the LD1 region in Leishmania includes DNA implicated in LD1 amplification

Mechanism of inhibition of trypanothione reductase and glutathione reductase by trivalent organic arsenicals

Site‐Directed Mutagenesis of the Redox‐Active Cysteines of Trypanosoma cruzi Trypanothione Reductase

Site-directed mutagenesis of the redox-active cysteines of Trypanosoma cruzi trypanothione reductase

The management of terminally ill patients

Trypanothione Reductase from Leishmania donovani

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