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Randomised clinical trial: arbaclofen placarbil in gastro‐oesophageal reflux disease – insights into study design for transient lower sphincter relaxation inhibitors

Alimentary pharmacology & therapeutics, 2013-07, Vol.38 (2), p.107-117

2013

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Clinical pharmacokinetics of the antiviral nucleotide analogues cidofovir and adefovir

Clinical pharmacokinetics, 1999-02, Vol.36 (2), p.127-143

CUNDY, K. C

1999

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Anti-Human Immunodeficiency Virus (HIV) Activity, Safety, and Pharmacokinetics of Adefovir Dipivoxil (9-[2-(bis-pivaloyloxymethyl)-phosphonylmethoxyethyl]adenine) in HIV-Infected Patients

The Journal of infectious diseases, 1997-08, Vol.176 (2), p.406-413

1997

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Identification of GS 4104 as an Orally Bioavailable Prodrug of the Influenza Virus Neuraminidase Inhibitor GS 4071

Antimicrobial Agents and Chemotherapy, 1998-03, Vol.42 (3), p.647-653

1998

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Antioxidant Activity of Carnosine, Homocarnosine, and Anserine Present in Muscle and Brain

Proceedings of the National Academy of Sciences - PNAS, 1988-05, Vol.85 (9), p.3175-3179

1988

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Clinical pharmacokinetics of cidofovir in human immunodeficiency virus-infected patients

Antimicrobial Agents and Chemotherapy, 1995-06, Vol.39 (6), p.1247-1252

1995

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Safety, Pharmacokinetics, and Antiretroviral Activity of Intravenous 9-[2-(R)-(Phosphonomethoxy)propyl]adenine, a Novel Anti-Human Immunodeficiency Virus (HIV) Therapy, in HIV-Infected Adults

Antimicrobial Agents and Chemotherapy, 1998-09, Vol.42 (9), p.2380-2384

1998

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Clinical pharmacokinetics of adefovir in human immunodeficiency virus type 1-infected patients

Antimicrobial Agents and Chemotherapy, 1995-11, Vol.39 (11), p.2401-2405

1995

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Penetration of GS4071, a novel influenza neuraminidase inhibitor, into rat bronchoalveolar lining fluid following oral administration of the prodrug GS4104

Antimicrobial Agents and Chemotherapy, 1997-09, Vol.41 (9), p.1949-1952

1997

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Effect of Oral Probenecid Coadministration on the Chronic Toxicity and Pharmacokinetics of Intravenous Cidofovir in Cynomolgus Monkeys

Toxicological sciences, 1998-08, Vol.44 (2), p.97-106

1998

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Metabolism and pharmacokinetics of novel oral prodrugs of 9-[(R)-2-(phosphonomethoxy)propyl]adenine (PMPA) in dogs

Pharmaceutical research, 1997-12, Vol.14 (12), p.1824-1829

1997

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Synthesis, in Vitro Biological Evaluation and Oral Bioavailability of 9-[2-(Phosphonomethoxy)Propyl]Adenine (PMPA) Prodrugs

Antiviral chemistry & chemotherapy, 1997-12, Vol.8 (6), p.557-564

1997

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Antiviral Efficacy and Pharmacokinetics of Oral Adefovir Dipivoxil in Chronically Woodchuck Hepatitis Virus-Infected Woodchucks

Antimicrobial Agents and Chemotherapy, 2001-10, Vol.45 (10), p.2740-2745

2001

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Metabolism of the influenza neuraminidase inhibitor prodrug oseltamivir in the rat

Drug metabolism and disposition, 2000-07, Vol.28 (7), p.737

2000

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Pharmacokinetics and Bioavailability of the Anti-Human Immunodeficiency Virus Nucleotide Analog 9-[(R)2-(Phosphonomethoxy)Propyl]Adenine (PMPA) in Dogs

Antimicrobial Agents and Chemotherapy, 1998-03, Vol.42 (3), p.687-690

1998

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Pharmacokinetics, safety and bioavailability of HPMPC (cidofovir) in human immunodeficiency virus-infected subjects

Antiviral research, 1996-03, Vol.29 (2), p.153-161

1996

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Pharmacokinetics, bioavailability, metabolism, and tissue distribution of cidofovir (HPMPC) and cyclic HPMPC in rats

Drug metabolism and disposition, 1996-07, Vol.24 (7), p.745

1996

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New Series of Potent, Orally Bioavailable, Non-Peptidic Cyclic Sulfones as HIV-1 Protease Inhibitors

Journal of medicinal chemistry, 1996-08, Vol.39 (18), p.3431-3434

1996

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1-[((S)-2-hydroxy-2-oxo-1,4,2-dioxaphosphorinan-5-yl)methyl] cytosine, an intracellular prodrug for (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine with improved therapeutic index in vivo

Antimicrobial Agents and Chemotherapy, 1994-10, Vol.38 (10), p.2387-2391

1994

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The effect of food with varying fat content on the clinical pharmacokinetics of gabapentin after oral administration of gabapentin enacarbil

International journal of clinical pharmacology and therapeutics, 2010-02, Vol.48 (2), p.120-128

2010

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Pharmacokinetics of cidofovir in monkeys. Evidence for a prolonged elimination phase representing phosphorylated drug

Drug metabolism and disposition, 1996-07, Vol.24 (7), p.738

1996

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Administration of 9-[2-(phosphonomethoxy)propyl]adenine (PMPA) for prevention of perinatal simian immunodeficiency virus infection in rhesus macaques

AIDS research and human retroviruses, 1998-06, Vol.14 (9), p.761-773

1998

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Effect of probenecid on the distribution, metabolism, and excretion of cidofovir in rabbits

Drug metabolism and disposition, 1996-03, Vol.24 (3), p.315

1996

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Oral, subcutaneous, and intramuscular bioavailabilities of the antiviral nucleotide analog 9-(2-phosphonylmethoxyethyl) adenine in cynomolgus monkeys

Antimicrobial Agents and Chemotherapy, 1994-02, Vol.38 (2), p.365-368

1994

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Detection of DNA adducts by high-performance liquid chromatography with electrochemical detection

Carcinogenesis (New York), 1989-05, Vol.10 (5), p.827-832

1989

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Randomised clinical trial: arbaclofen placarbil in gastro‐oesophageal reflux disease – insights into study design for transient lower sphincter relaxation inhibitors

Clinical pharmacokinetics of the antiviral nucleotide analogues cidofovir and adefovir

Anti-Human Immunodeficiency Virus (HIV) Activity, Safety, and Pharmacokinetics of Adefovir Dipivoxil (9-[2-(bis-pivaloyloxymethyl)-phosphonylmethoxyethyl]adenine) in HIV-Infected Patients

Identification of GS 4104 as an Orally Bioavailable Prodrug of the Influenza Virus Neuraminidase Inhibitor GS 4071

Antioxidant Activity of Carnosine, Homocarnosine, and Anserine Present in Muscle and Brain

Clinical pharmacokinetics of cidofovir in human immunodeficiency virus-infected patients

Safety, Pharmacokinetics, and Antiretroviral Activity of Intravenous 9-[2-(R)-(Phosphonomethoxy)propyl]adenine, a Novel Anti-Human Immunodeficiency Virus (HIV) Therapy, in HIV-Infected Adults

Clinical pharmacokinetics of adefovir in human immunodeficiency virus type 1-infected patients

Penetration of GS4071, a novel influenza neuraminidase inhibitor, into rat bronchoalveolar lining fluid following oral administration of the prodrug GS4104

Effect of Oral Probenecid Coadministration on the Chronic Toxicity and Pharmacokinetics of Intravenous Cidofovir in Cynomolgus Monkeys

Metabolism and pharmacokinetics of novel oral prodrugs of 9-[(R)-2-(phosphonomethoxy)propyl]adenine (PMPA) in dogs

Synthesis, in Vitro Biological Evaluation and Oral Bioavailability of 9-[2-(Phosphonomethoxy)Propyl]Adenine (PMPA) Prodrugs

Antiviral Efficacy and Pharmacokinetics of Oral Adefovir Dipivoxil in Chronically Woodchuck Hepatitis Virus-Infected Woodchucks

Metabolism of the influenza neuraminidase inhibitor prodrug oseltamivir in the rat

Pharmacokinetics and Bioavailability of the Anti-Human Immunodeficiency Virus Nucleotide Analog 9-[(R)2-(Phosphonomethoxy)Propyl]Adenine (PMPA) in Dogs

Pharmacokinetics, safety and bioavailability of HPMPC (cidofovir) in human immunodeficiency virus-infected subjects

Pharmacokinetics, bioavailability, metabolism, and tissue distribution of cidofovir (HPMPC) and cyclic HPMPC in rats

New Series of Potent, Orally Bioavailable, Non-Peptidic Cyclic Sulfones as HIV-1 Protease Inhibitors

1-[((S)-2-hydroxy-2-oxo-1,4,2-dioxaphosphorinan-5-yl)methyl] cytosine, an intracellular prodrug for (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine with improved therapeutic index in vivo

The effect of food with varying fat content on the clinical pharmacokinetics of gabapentin after oral administration of gabapentin enacarbil

Pharmacokinetics of cidofovir in monkeys. Evidence for a prolonged elimination phase representing phosphorylated drug

Administration of 9-[2-(phosphonomethoxy)propyl]adenine (PMPA) for prevention of perinatal simian immunodeficiency virus infection in rhesus macaques

Effect of probenecid on the distribution, metabolism, and excretion of cidofovir in rabbits

Oral, subcutaneous, and intramuscular bioavailabilities of the antiviral nucleotide analog 9-(2-phosphonylmethoxyethyl) adenine in cynomolgus monkeys

Detection of DNA adducts by high-performance liquid chromatography with electrochemical detection

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