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Protein Hydroxylation by Hypoxia-Inducible Factor (HIF) Hydroxylases: Unique or Ubiquitous?

Cells (Basel, Switzerland), 2019-04, Vol.8 (5), p.384

2019

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Orphan Nuclear Receptor Family 4A (NR4A) Members NR4A2 and NR4A3 Selectively Modulate Elements of the Monocyte Response to Buffered Hypercapnia

International journal of molecular sciences, 2024-03, Vol.25 (5), p.2852

2024

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Regulation of IL-1β–induced NF-κB by hydroxylases links key hypoxic and inflammatory signaling pathways

Proceedings of the National Academy of Sciences - PNAS, 2013-11, Vol.110 (46), p.18490-18495

2013

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The Hydroxylase Inhibitor Dimethyloxalylglycine Is Protective in a Murine Model of Colitis

Gastroenterology (New York, N.Y. 1943), 2008, Vol.134 (1), p.156-165.e1

2008

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Prolyl hydroxylase-1 negatively regulates IκB kinase-β, giving insight into hypoxia-induced NFκB activity

Proceedings of the National Academy of Sciences - PNAS, 2006-11, Vol.103 (48), p.18154-18159

2006

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FIH Regulates Cellular Metabolism through Hydroxylation of the Deubiquitinase OTUB1

PLoS biology, 2016-01, Vol.14 (1), p.e1002347

2016

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Adenosine Modulates NR4A Orphan Nuclear Receptors To Attenuate Hyperinflammatory Responses in Monocytic Cells

The Journal of immunology (1950), 2015-08, Vol.195 (4), p.1436-1448

2015

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Editorial: Elevated Carbon Dioxide Sensing and Physiologic Effects

Frontiers in physiology, 2022-04, Vol.13, p.894222-894222

2022

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A dynamic model of the hypoxia-inducible factor 1α (HIF-1α) network

Journal of cell science, 2013-03, Vol.126 (Pt 6), p.1454-1463

2013

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REST mediates resolution of HIF-dependent gene expression in prolonged hypoxia

Scientific reports, 2015-12, Vol.5 (1), p.17851-17851, Article 17851

2015

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Transcriptional Profiling of Monocytes Deficient in Nuclear Orphan Receptors NR4A2 and NR4A3 Reveals Distinct Signalling Roles Related to Antigen Presentation and Viral Response

Frontiers in immunology, 2021-06, Vol.12, p.676644-676644

2021

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REST is a hypoxia-responsive transcriptional repressor

Scientific reports, 2016-08, Vol.6 (1), p.31355-31355, Article 31355

2016

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Gremlin Plays a Key Role in the Pathogenesis of Pulmonary Hypertension

Circulation (New York, N.Y.), 2012-02, Vol.125 (7), p.920-930

2012

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Mechanisms and Consequences of Oxygen and Carbon Dioxide Sensing in Mammals

Physiological reviews, 2020-01, Vol.100 (1), p.463-488

2020

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PGC-1α is coupled to HIF-1α-dependent gene expression by increasing mitochondrial oxygen consumption in skeletal muscle cells

Proceedings of the National Academy of Sciences - PNAS, 2009-02, Vol.106 (7), p.2188-2193

2009

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Hypoxia and inflammatory bowel disease

Microbes and infection, 2017-03, Vol.19 (3), p.210-221

2017

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Hypoxia-dependent regulation of inflammatory pathways in immune cells

The Journal of clinical investigation, 2016-10, Vol.126 (10), p.3716-3724

2016

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The hydroxylase inhibitor dimethyloxallyl glycine attenuates endotoxic shock via alternative activation of macrophages and IL-10 production by B1 cells

Shock (Augusta, Ga.), 2011-09, Vol.36 (3), p.295-302

2011

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The role of HIF in immunity and inflammation

Molecular aspects of medicine, 2016-02, Vol.47-48, p.24-34

2016

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Small Ubiquitin-related Modifier (SUMO)-1 Promotes Glycolysis in Hypoxia

The Journal of biological chemistry, 2011-02, Vol.286 (6), p.4718-4726

2011

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Physiological gases in health and disease – key regulatory factors, not just a lot of hot air

The Journal of physiology, 2017-04, Vol.595 (8), p.2421-2422

Cummins, Eoin P.

2017

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Understanding the pathophysiological mechanisms of cardiometabolic complications in obstructive sleep apnoea: towards personalised treatment approaches

The European respiratory journal, 2020-08, Vol.56 (2), p.1902295

2020

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Hydroxylase inhibition regulates inflammation-induced intestinal fibrosis through the suppression of ERK-mediated TGF-β1 signaling. [corrected]

American journal of physiology: Gastrointestinal and liver physiology, 2016-12, Vol.311 (6), p.G1076-G1090

2016

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Hypoxia-responsive transcription factors

Pflügers Archiv, 2005-09, Vol.450 (6), p.363-371

2005

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MicroRNA-155 Promotes Resolution of Hypoxia-Inducible Factor 1α Activity during Prolonged Hypoxia

Molecular and Cellular Biology, 2011-10, Vol.31 (19), p.4087-4096

2011

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Protein Hydroxylation by Hypoxia-Inducible Factor (HIF) Hydroxylases: Unique or Ubiquitous?

Orphan Nuclear Receptor Family 4A (NR4A) Members NR4A2 and NR4A3 Selectively Modulate Elements of the Monocyte Response to Buffered Hypercapnia

Regulation of IL-1β–induced NF-κB by hydroxylases links key hypoxic and inflammatory signaling pathways

The Hydroxylase Inhibitor Dimethyloxalylglycine Is Protective in a Murine Model of Colitis

Prolyl hydroxylase-1 negatively regulates IκB kinase-β, giving insight into hypoxia-induced NFκB activity

FIH Regulates Cellular Metabolism through Hydroxylation of the Deubiquitinase OTUB1

Adenosine Modulates NR4A Orphan Nuclear Receptors To Attenuate Hyperinflammatory Responses in Monocytic Cells

Editorial: Elevated Carbon Dioxide Sensing and Physiologic Effects

A dynamic model of the hypoxia-inducible factor 1α (HIF-1α) network

REST mediates resolution of HIF-dependent gene expression in prolonged hypoxia

Transcriptional Profiling of Monocytes Deficient in Nuclear Orphan Receptors NR4A2 and NR4A3 Reveals Distinct Signalling Roles Related to Antigen Presentation and Viral Response

REST is a hypoxia-responsive transcriptional repressor

Gremlin Plays a Key Role in the Pathogenesis of Pulmonary Hypertension

Mechanisms and Consequences of Oxygen and Carbon Dioxide Sensing in Mammals

PGC-1α is coupled to HIF-1α-dependent gene expression by increasing mitochondrial oxygen consumption in skeletal muscle cells

Hypoxia and inflammatory bowel disease

Hypoxia-dependent regulation of inflammatory pathways in immune cells

The hydroxylase inhibitor dimethyloxallyl glycine attenuates endotoxic shock via alternative activation of macrophages and IL-10 production by B1 cells

The role of HIF in immunity and inflammation

Small Ubiquitin-related Modifier (SUMO)-1 Promotes Glycolysis in Hypoxia

Physiological gases in health and disease – key regulatory factors, not just a lot of hot air

Understanding the pathophysiological mechanisms of cardiometabolic complications in obstructive sleep apnoea: towards personalised treatment approaches

Hydroxylase inhibition regulates inflammation-induced intestinal fibrosis through the suppression of ERK-mediated TGF-β1 signaling. [corrected]

Hypoxia-responsive transcription factors

MicroRNA-155 Promotes Resolution of Hypoxia-Inducible Factor 1α Activity during Prolonged Hypoxia

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