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A stable and reproducible human blood-brain barrier model derived from hematopoietic stem cells

PloS one, 2014-06, Vol.9 (6), p.e99733-e99733

2014

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Mimicking brain tissue binding in an in vitro model of the blood-brain barrier illustrates differences between in vitro and in vivo methods for assessing the rate of brain penetration

European journal of pharmaceutics and biopharmaceutics, 2018-06, Vol.127, p.453-461

2018

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Endothelial calcium dynamics, connexin channels and blood-brain barrier function

Progress in neurobiology, 2013-09, Vol.108, p.1-20

2013

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A Miniaturized Pump Out Method for Characterizing Molecule Interaction with ABC Transporters

International journal of molecular sciences, 2019-11, Vol.20 (22), p.5529

2019

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A new angle on blood–CNS interfaces: A role for connexins?

FEBS letters, 2014-04, Vol.588 (8), p.1259-1270

2014

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Homology Modeling of the Human P-glycoprotein (ABCB1) and Insights into Ligand Binding through Molecular Docking Studies

International journal of molecular sciences, 2020-06, Vol.21 (11), p.4058

2020

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Contribution of brain pericytes in blood-brain barrier formation and maintenance: a transcriptomic study of cocultured human endothelial cells derived from hematopoietic stem cells

Fluids and barriers of the CNS, 2020-07, Vol.17 (1), p.48-48, Article 48

2020

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Connexin channels provide a target to manipulate brain endothelial calcium dynamics and blood-brain barrier permeability

Journal of cerebral blood flow and metabolism, 2011-09, Vol.31 (9), p.1942-1957

2011

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Catalytic site inhibition of insulin-degrading enzyme by a small molecule induces glucose intolerance in mice

Nature communications, 2015-09, Vol.6 (1), p.8250-8250, Article 8250

2015

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An in vitro strategy using multiple human induced pluripotent stem cell-derived models to assess the toxicity of chemicals: A case study on paraquat

Toxicology in vitro, 2022-06, Vol.81, p.105333-105333, Article 105333

2022

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Challenges and Opportunities in the Oral Delivery of Recombinant Biologics

Pharmaceutics, 2023-05, Vol.15 (5), p.1415

2023

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Evaluation of drug-induced neurotoxicity based on metabolomics, proteomics and electrical activity measurements in complementary CNS in vitro models

Toxicology in vitro, 2015-12, Vol.30 (1), p.138-165

2015

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In vitro blood–brain barrier permeability predictions for GABAA receptor modulating piperine analogs

European journal of pharmaceutics and biopharmaceutics, 2016-06, Vol.103, p.118-126

2016

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Transport study of interleukin-1 inhibitors using a human in vitro model of the blood-brain barrier

Brain, behavior, & immunity. Health, 2021-10, Vol.16, p.100307-100307, Article 100307

2021

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Enhancing Oral Delivery of Biologics: A Non-Competitive and Cross-Reactive Anti-Leptin Receptor Nanofitin Demonstrates a Gut-Crossing Capacity in an Ex Vivo Porcine Intestinal Model

Pharmaceutics, 2024-01, Vol.16 (1), p.116

2024

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Differential Blood-Brain Barrier Transport and Cell Uptake of Cyclic Peptides In Vivo and In Vitro

Pharmaceutics, 2023-05, Vol.15 (5), p.1507

2023

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A simple method for assessing free brain/free plasma ratios using an in vitro model of the blood brain barrier

PloS one, 2013-12, Vol.8 (12), p.e80634-e80634

2013

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An in vitro blood-brain barrier model for high throughput (HTS) toxicological screening

Toxicology in vitro, 2008-04, Vol.22 (3), p.799-811

2008

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Central nervous system delivery of molecules across the blood-brain barrier

Neurochemistry international, 2021-03, Vol.144, p.104952-104952, Article 104952

2021

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Challenges and opportunities in the use of transcriptomic characterization of human iPSC-derived BBB models

Toxicology in vitro, 2022-10, Vol.84, p.105424-105424, Article 105424

2022

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Challenges and opportunities in the use of transcriptomics characterization for human iPSC-derived BBB models

Toxicology in vitro, 2022

2022

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Peroxisome-proliferator-activated receptor-alpha activation protects brain capillary endothelial cells from oxygen-glucose deprivation-induced hyperpermeability in the blood-brain barrier

Current neurovascular research, 2009-08, Vol.6 (3), p.181-193

2009

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Brain pericytes from stress-susceptible pigs increase blood-brain barrier permeability in vitro

Fluids and barriers of the CNS, 2012-06, Vol.9 (1), p.11-11

2012

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A snapshot on the progress of in vitro toxicology for safety assessment

Toxicology in vitro, 2017-12, Vol.45 (Pt 3), p.269-271

2017

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Modelling of the blood-brain barrier in drug discovery and development

Nature reviews. Drug discovery, 2007-08, Vol.6 (8), p.650-661

2007

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A stable and reproducible human blood-brain barrier model derived from hematopoietic stem cells

Mimicking brain tissue binding in an in vitro model of the blood-brain barrier illustrates differences between in vitro and in vivo methods for assessing the rate of brain penetration

Endothelial calcium dynamics, connexin channels and blood-brain barrier function

A Miniaturized Pump Out Method for Characterizing Molecule Interaction with ABC Transporters

A new angle on blood–CNS interfaces: A role for connexins?

Homology Modeling of the Human P-glycoprotein (ABCB1) and Insights into Ligand Binding through Molecular Docking Studies

Contribution of brain pericytes in blood-brain barrier formation and maintenance: a transcriptomic study of cocultured human endothelial cells derived from hematopoietic stem cells

Connexin channels provide a target to manipulate brain endothelial calcium dynamics and blood-brain barrier permeability

Catalytic site inhibition of insulin-degrading enzyme by a small molecule induces glucose intolerance in mice

An in vitro strategy using multiple human induced pluripotent stem cell-derived models to assess the toxicity of chemicals: A case study on paraquat

Challenges and Opportunities in the Oral Delivery of Recombinant Biologics

Evaluation of drug-induced neurotoxicity based on metabolomics, proteomics and electrical activity measurements in complementary CNS in vitro models

In vitro blood–brain barrier permeability predictions for GABAA receptor modulating piperine analogs

Transport study of interleukin-1 inhibitors using a human in vitro model of the blood-brain barrier

Enhancing Oral Delivery of Biologics: A Non-Competitive and Cross-Reactive Anti-Leptin Receptor Nanofitin Demonstrates a Gut-Crossing Capacity in an Ex Vivo Porcine Intestinal Model

Differential Blood-Brain Barrier Transport and Cell Uptake of Cyclic Peptides In Vivo and In Vitro

A simple method for assessing free brain/free plasma ratios using an in vitro model of the blood brain barrier

An in vitro blood-brain barrier model for high throughput (HTS) toxicological screening

Central nervous system delivery of molecules across the blood-brain barrier

Challenges and opportunities in the use of transcriptomic characterization of human iPSC-derived BBB models

Challenges and opportunities in the use of transcriptomics characterization for human iPSC-derived BBB models

Peroxisome-proliferator-activated receptor-alpha activation protects brain capillary endothelial cells from oxygen-glucose deprivation-induced hyperpermeability in the blood-brain barrier

Brain pericytes from stress-susceptible pigs increase blood-brain barrier permeability in vitro

A snapshot on the progress of in vitro toxicology for safety assessment

Modelling of the blood-brain barrier in drug discovery and development

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