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Design, Synthesis, and Structure–Activity Relationship Studies of Fluorescent Inhibitors of Cycloxygenase‑2 as Targeted Optical Imaging Agents

Bioconjugate chemistry, 2013-04, Vol.24 (4), p.712-723

2013

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Selective Visualization of Cyclooxygenase-2 in Inflammation and Cancer by Targeted Fluorescent Imaging Agents

Cancer research (Chicago, Ill.), 2010-05, Vol.70 (9), p.3618-3627

2010

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Prostaglandin E2 glyceryl ester is an endogenous agonist of the nucleotide receptor P2Y6

Scientific reports, 2017-05, Vol.7 (1), p.1-15, Article 2380

2017

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Cyclooxygenase-1-Selective Inhibitors Based on the (E)-2′-Des-methyl-sulindac Sulfide Scaffold

Journal of medicinal chemistry, 2012-03, Vol.55 (5), p.2287-2300

2012

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nido-Dicarbaborate Induces Potent and Selective Inhibition of Cyclooxygenase-2

ChemMedChem, 2016-01, Vol.11 (2), p.175-178

2016

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Inhibition of the Biosynthesis of Prostaglandin E2 By Low-Dose Aspirin: Implications for Adenocarcinoma Metastasis

Cancer prevention research (Philadelphia, Pa.), 2016-11, Vol.9 (11), p.855-865

2016

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Metabolism of the Endocannabinoids, 2-Arachidonylglycerol and Anandamide, into Prostaglandin, Thromboxane, and Prostacyclin Glycerol Esters and Ethanolamides

The Journal of biological chemistry, 2002-11, Vol.277 (47), p.44877-44885

2002

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Ester and Amide Derivatives of the Nonsteroidal Antiinflammatory Drug, Indomethacin, as Selective Cyclooxygenase-2 Inhibitors

Journal of medicinal chemistry, 2000-07, Vol.43 (15), p.2860-2870

2000

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Trifluoromethyl Fluorocoxib A Detects Cyclooxygenase‑2 Expression in Inflammatory Tissues and Human Tumor Xenografts

ACS medicinal chemistry letters, 2014-04, Vol.5 (4), p.446-450

2014

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Peroxynitrite, the Coupling Product of Nitric Oxide and Superoxide, Activates Prostaglandin Biosynthesis

Proceedings of the National Academy of Sciences - PNAS, 1996-12, Vol.93 (26), p.15069-15074

1996

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The glyceryl ester of prostaglandin E2 mobilizes calcium and activates signal transduction in RAW264.7 cells

Proceedings of the National Academy of Sciences - PNAS, 2004-02, Vol.101 (7), p.1840-1845

2004

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Biochemically Based Design of Cyclooxygenase-2 (COX-2) Inhibitors: Facile Conversion of Nonsteroidal Antiinflammatory Drugs to Potent and Highly Selective COX-2 Inhibitors

Proceedings of the National Academy of Sciences - PNAS, 2000-01, Vol.97 (2), p.925-930

2000

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Discovery of Furanone-Based Radiopharmaceuticals for Diagnostic Targeting of COX‑1 in Ovarian Cancer

ACS omega, 2019-05, Vol.4 (5), p.9251-9261

2019

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Conjugates of Cisplatin and Cyclooxygenase Inhibitors as Potent Antitumor Agents Overcoming Cisplatin Resistance

ChemMedChem, 2014-06, Vol.9 (6), p.1150-1153

2014

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In vivo Oxidative Metabolism of a Major Peroxidation-Derived DNA Adduct, M₁dG

Proceedings of the National Academy of Sciences - PNAS, 2006-04, Vol.103 (17), p.6665-6669

2006

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Conjugation of Cisplatin Analogues and Cyclooxygenase Inhibitors to Overcome Cisplatin Resistance

ChemMedChem, 2015-01, Vol.10 (1), p.183-192

2015

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Fluorocoxib A loaded nanoparticles enable targeted visualization of cyclooxygenase-2 in inflammation and cancer

Biomaterials, 2016-06, Vol.92, p.71-80

2016

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Harmaline Analogs as Substrate-Selective Cyclooxygenase‑2 Inhibitors

ACS medicinal chemistry letters, 2020-10, Vol.11 (10), p.1881-1885

2020

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Ferroptosis Inhibitors Suppress Prostaglandin Synthesis in Lipopolysaccharide-Stimulated Macrophages

ACS chemical biology, 2023-02, Vol.18 (2), p.404-418

2023

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Discovery of a Redox-Activatable Chemical Probe for Detection of Cyclooxygenase‑2 in Cells and Animals

ACS chemical biology, 2022-07, Vol.17 (7), p.1714-1722

2022

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Metabolism in Vitro and in Vivo of the DNA Base Adduct, M1G

Chemical research in toxicology, 2007-03, Vol.20 (3), p.550-557

2007

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Targeted Detection of Cyclooxygenase‑1 in Ovarian Cancer

ACS medicinal chemistry letters, 2020-10, Vol.11 (10), p.1837-1842

2020

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Antitumor Activity of Cytotoxic Cyclooxygenase‑2 Inhibitors

ACS chemical biology, 2016-11, Vol.11 (11), p.3052-3060

2016

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Fluorinated COX-2 inhibitors as agents in PET imaging of inflammation and cancer

Cancer prevention research (Philadelphia, Pa.), 2011-10, Vol.4 (10), p.1536-1545

2011

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The 2′-Trifluoromethyl Analogue of Indomethacin Is a Potent and Selective COX‑2 Inhibitor

ACS medicinal chemistry letters, 2013-05, Vol.4 (5), p.486-490

2013

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Design, Synthesis, and Structure–Activity Relationship Studies of Fluorescent Inhibitors of Cycloxygenase‑2 as Targeted Optical Imaging Agents

Selective Visualization of Cyclooxygenase-2 in Inflammation and Cancer by Targeted Fluorescent Imaging Agents

Prostaglandin E2 glyceryl ester is an endogenous agonist of the nucleotide receptor P2Y6

Cyclooxygenase-1-Selective Inhibitors Based on the (E)-2′-Des-methyl-sulindac Sulfide Scaffold

nido-Dicarbaborate Induces Potent and Selective Inhibition of Cyclooxygenase-2

Inhibition of the Biosynthesis of Prostaglandin E2 By Low-Dose Aspirin: Implications for Adenocarcinoma Metastasis

Metabolism of the Endocannabinoids, 2-Arachidonylglycerol and Anandamide, into Prostaglandin, Thromboxane, and Prostacyclin Glycerol Esters and Ethanolamides

Ester and Amide Derivatives of the Nonsteroidal Antiinflammatory Drug, Indomethacin, as Selective Cyclooxygenase-2 Inhibitors

Trifluoromethyl Fluorocoxib A Detects Cyclooxygenase‑2 Expression in Inflammatory Tissues and Human Tumor Xenografts

Peroxynitrite, the Coupling Product of Nitric Oxide and Superoxide, Activates Prostaglandin Biosynthesis

The glyceryl ester of prostaglandin E2 mobilizes calcium and activates signal transduction in RAW264.7 cells

Biochemically Based Design of Cyclooxygenase-2 (COX-2) Inhibitors: Facile Conversion of Nonsteroidal Antiinflammatory Drugs to Potent and Highly Selective COX-2 Inhibitors

Discovery of Furanone-Based Radiopharmaceuticals for Diagnostic Targeting of COX‑1 in Ovarian Cancer

Conjugates of Cisplatin and Cyclooxygenase Inhibitors as Potent Antitumor Agents Overcoming Cisplatin Resistance

In vivo Oxidative Metabolism of a Major Peroxidation-Derived DNA Adduct, M₁dG

Conjugation of Cisplatin Analogues and Cyclooxygenase Inhibitors to Overcome Cisplatin Resistance

Fluorocoxib A loaded nanoparticles enable targeted visualization of cyclooxygenase-2 in inflammation and cancer

Harmaline Analogs as Substrate-Selective Cyclooxygenase‑2 Inhibitors

Ferroptosis Inhibitors Suppress Prostaglandin Synthesis in Lipopolysaccharide-Stimulated Macrophages

Discovery of a Redox-Activatable Chemical Probe for Detection of Cyclooxygenase‑2 in Cells and Animals

Metabolism in Vitro and in Vivo of the DNA Base Adduct, M1G

Targeted Detection of Cyclooxygenase‑1 in Ovarian Cancer

Antitumor Activity of Cytotoxic Cyclooxygenase‑2 Inhibitors

Fluorinated COX-2 inhibitors as agents in PET imaging of inflammation and cancer

The 2′-Trifluoromethyl Analogue of Indomethacin Is a Potent and Selective COX‑2 Inhibitor

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