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A Novel Design of Artificial Membrane for Improving the PAMPA Model

Pharmaceutical research, 2008-07, Vol.25 (7), p.1511-1520

2008

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In Vitro Drug Metabolism Using Liver Microsomes

Current Protocols in Pharmacology, 2016-09, Vol.74 (1), p.7.8.1-7.8.24

2016

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Substrate-dependent modulation of CYP3A4 catalytic activity: analysis of 27 test compounds with four fluorometric substrates

Drug metabolism and disposition, 2000-12, Vol.28 (12), p.1440

2000

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CYP2C8 polymorphisms in Caucasians and their relationship with paclitaxel 6α-hydroxylase activity in human liver microsomes

Biochemical pharmacology, 2002-12, Vol.64 (11), p.1579-1589

2002

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Comparison between cytochrome P450 (CYP) content and relative activity approaches to scaling from cDNA-expressed CYPs to human liver microsomes: ratios of accessory proteins as sources of discrepancies between the approaches

Drug metabolism and disposition, 2000-12, Vol.28 (12), p.1493

2000

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HIGHLY SELECTIVE INHIBITION OF HUMAN CYP3A IN VITRO BY AZAMULIN AND EVIDENCE THAT INHIBITION IS IRREVERSIBLE

Drug metabolism and disposition, 2004-01, Vol.32 (1), p.105-112

2004

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Cytochrome P450 fluorometric substrates: identification of isoform-selective probes for rat CYP2D2 and human CYP3A4

Drug metabolism and disposition, 2002-07, Vol.30 (7), p.845-852

2002

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Human-Cell Mutagens in Respirable Airborne Particles in the Northeastern United States. 1. Mutagenicity of Fractionated Samples

Environmental science & technology, 2004-02, Vol.38 (3), p.682-689

2004

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Spectrophotometric analysis of human CYP2E1-catalyzed p-nitrophenol hydroxylation

Methods in molecular biology (Clifton, N.J.), 2006, Vol.320, p.127

2006

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Differential time- and NADPH-dependent inhibition of CYP2C19 by enantiomers of fluoxetine

Drug metabolism and disposition, 2009-04, Vol.37 (4), p.695-698

2009

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The use of heterologously expressed drug metabolizing enzymes— state of the art and prospects for the future

Pharmacology & therapeutics (Oxford), 1999-11, Vol.84 (2), p.121-131

1999

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A Multi-Endpoint Evaluation of Cytochrome P450 1A2, 2B6 and 3A4 Induction Response in Human Hepatocyte Cultures After Treatment with β - Naphthoflavone, Phenobarbital and Rifampicin

Drug metabolism letters, 2010-12, Vol.4 (4), p.185-194

2010

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Comparison of Species Differences of P-Glycoproteins in Beagle Dog, Rhesus Monkey, and Human Using ATPase Activity Assays

Molecular pharmaceutics, 2006-01, Vol.3 (1), p.78-86

2006

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Human cytochrome p450 induction and inhibition potential of clevidipine and its primary metabolite h152/81

Drug metabolism and disposition, 2006-05, Vol.34 (5), p.734-737

2006

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Development of a substrate-activity based approach to identify the major human liver P-450 catalysts of cyclophosphamide and ifosfamide activation based on cDNA-expressed activities and liver microsomal P-450 profiles

Drug metabolism and disposition, 1999-06, Vol.27 (6), p.655

1999

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Microtiter Plate Assays for Inhibition of Human, Drug-Metabolizing Cytochromes P450

Analytical biochemistry, 1997-05, Vol.248 (1), p.188-190

1997

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Bioassay-Directed Chemical Analysis of Los Angeles Airborne Particulate Matter Using a Human Cell Mutagenicity Assay

Environmental science & technology, 1998-11, Vol.32 (22), p.3502-3514

1998

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Characterizations of corning® hepatocells as a novel in vitro tool for drug metabolism and hepatotoxicity studies

Drug metabolism and pharmacokinetics, 2017-01, Vol.32 (1), p.S106-S106

2017

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A new cell-based model to study the important matters of OATP1B on drug disposition: Genetic variants and species differences

Drug metabolism and pharmacokinetics, 2017-01, Vol.32 (1), p.S106-S106

2017

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Mutagenicity of C24H14 PAH in human cells expressing CYP1A1

Mutation research. Genetic toxicology and environmental mutagenesis, 1999-10, Vol.446 (1), p.1-14

1999

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Quantitative RT-PCR Measurement of Cytochromes p450 1A1, 1B1, and 2B7, Microsomal Epoxide Hydrolase, and NADPH Oxidoreductase Expression in Lung Cells of Smokers and Nonsmokers

American journal of respiratory cell and molecular biology, 1997-07, Vol.17 (1), p.114-124

1997

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Characterization of cytochrome P450 2D6.1 (CYP2D6.1), CYP2D6.2, and CYP2D6.17 activities toward model CYP2D6 substrates dextromethorphan, bufuralol, and debrisoquine

Drug metabolism and disposition, 2002-05, Vol.30 (5), p.595-601

2002

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CYP2D6-dependent bufuralol 1'-hydroxylation assayed by reverse-phase ion-pair high-performance liquid chromatography with fluorescence detection

Methods in molecular biology (Clifton, N.J.), 2006, Vol.320, p.121

2006

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Determination of CYP2B6 component of 7-ethoxy-4-trifluoromethylcoumarin O-deethylation activity in human liver microsomes

Methods in molecular biology (Clifton, N.J.), 2006, Vol.320, p.97

2006

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A High-Throughput Screen to Identify Inhibitors of Aromatase (CYP19)

Analytical biochemistry, 2000-09, Vol.284 (2), p.427-430

2000

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A Novel Design of Artificial Membrane for Improving the PAMPA Model

In Vitro Drug Metabolism Using Liver Microsomes

Substrate-dependent modulation of CYP3A4 catalytic activity: analysis of 27 test compounds with four fluorometric substrates

CYP2C8 polymorphisms in Caucasians and their relationship with paclitaxel 6α-hydroxylase activity in human liver microsomes

Comparison between cytochrome P450 (CYP) content and relative activity approaches to scaling from cDNA-expressed CYPs to human liver microsomes: ratios of accessory proteins as sources of discrepancies between the approaches

HIGHLY SELECTIVE INHIBITION OF HUMAN CYP3A IN VITRO BY AZAMULIN AND EVIDENCE THAT INHIBITION IS IRREVERSIBLE

Cytochrome P450 fluorometric substrates: identification of isoform-selective probes for rat CYP2D2 and human CYP3A4

Human-Cell Mutagens in Respirable Airborne Particles in the Northeastern United States. 1. Mutagenicity of Fractionated Samples

Spectrophotometric analysis of human CYP2E1-catalyzed p-nitrophenol hydroxylation

Differential time- and NADPH-dependent inhibition of CYP2C19 by enantiomers of fluoxetine

The use of heterologously expressed drug metabolizing enzymes— state of the art and prospects for the future

A Multi-Endpoint Evaluation of Cytochrome P450 1A2, 2B6 and 3A4 Induction Response in Human Hepatocyte Cultures After Treatment with β - Naphthoflavone, Phenobarbital and Rifampicin

Comparison of Species Differences of P-Glycoproteins in Beagle Dog, Rhesus Monkey, and Human Using ATPase Activity Assays

Human cytochrome p450 induction and inhibition potential of clevidipine and its primary metabolite h152/81

Development of a substrate-activity based approach to identify the major human liver P-450 catalysts of cyclophosphamide and ifosfamide activation based on cDNA-expressed activities and liver microsomal P-450 profiles

Microtiter Plate Assays for Inhibition of Human, Drug-Metabolizing Cytochromes P450

Bioassay-Directed Chemical Analysis of Los Angeles Airborne Particulate Matter Using a Human Cell Mutagenicity Assay

Characterizations of corning® hepatocells as a novel in vitro tool for drug metabolism and hepatotoxicity studies

A new cell-based model to study the important matters of OATP1B on drug disposition: Genetic variants and species differences

Mutagenicity of C24H14 PAH in human cells expressing CYP1A1

Quantitative RT-PCR Measurement of Cytochromes p450 1A1, 1B1, and 2B7, Microsomal Epoxide Hydrolase, and NADPH Oxidoreductase Expression in Lung Cells of Smokers and Nonsmokers

Characterization of cytochrome P450 2D6.1 (CYP2D6.1), CYP2D6.2, and CYP2D6.17 activities toward model CYP2D6 substrates dextromethorphan, bufuralol, and debrisoquine

CYP2D6-dependent bufuralol 1'-hydroxylation assayed by reverse-phase ion-pair high-performance liquid chromatography with fluorescence detection

Determination of CYP2B6 component of 7-ethoxy-4-trifluoromethylcoumarin O-deethylation activity in human liver microsomes

A High-Throughput Screen to Identify Inhibitors of Aromatase (CYP19)

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