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Development of a substrate-activity based approach to identify the major human liver P-450 catalysts of cyclophosphamide and ifosfamide activation based on cDNA-expressed activities and liver microsomal P-450 profiles

Drug metabolism and disposition, 1999-06, Vol.27 (6), p.655

1999

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Substrate-dependent modulation of CYP3A4 catalytic activity: analysis of 27 test compounds with four fluorometric substrates

Drug metabolism and disposition, 2000-12, Vol.28 (12), p.1440

2000

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Cytochrome P450 fluorometric substrates: identification of isoform-selective probes for rat CYP2D2 and human CYP3A4

Drug metabolism and disposition, 2002-07, Vol.30 (7), p.845-852

2002

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Design and application of fluorometric assays for human cytochrome P450 inhibition

Methods in Enzymology, 2002, Vol.357, p.276-284

2002

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CYP2C8 polymorphisms in Caucasians and their relationship with paclitaxel 6α-hydroxylase activity in human liver microsomes

Biochemical pharmacology, 2002-12, Vol.64 (11), p.1579-1589

2002

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CYP3A4 allelic variants with amino acid substitutions in exons 7 and 12: Evidence for an allelic variant with altered catalytic activity

Clinical pharmacology and therapeutics, 2000-01, Vol.67 (1), p.48-56

2000

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Microtiter Plate Assays for Inhibition of Human, Drug-Metabolizing Cytochromes P450

Analytical biochemistry, 1997-05, Vol.248 (1), p.188-190

1997

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Comparison between cytochrome P450 (CYP) content and relative activity approaches to scaling from cDNA-expressed CYPs to human liver microsomes: ratios of accessory proteins as sources of discrepancies between the approaches

Drug metabolism and disposition, 2000-12, Vol.28 (12), p.1493

2000

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Effect of methanol, ethanol, dimethyl sulfoxide, and acetonitrile on in vitro activities of cDNA-expressed human cytochromes P-450

Drug metabolism and disposition, 1999-02, Vol.27 (2), p.246

1999

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The use of heterologously expressed drug metabolizing enzymes— state of the art and prospects for the future

Pharmacology & therapeutics (Oxford), 1999-11, Vol.84 (2), p.121-131

1999

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HIGHLY SELECTIVE INHIBITION OF HUMAN CYP3A IN VITRO BY AZAMULIN AND EVIDENCE THAT INHIBITION IS IRREVERSIBLE

Drug metabolism and disposition, 2004-01, Vol.32 (1), p.105-112

2004

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Metabolism: a bottleneck in in vitro toxicological test development. The report and recommendations of ECVAM workshop 54

Alternatives to laboratory animals, 2006-02, Vol.34 (1), p.49-84

2006

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DNA Damage and Mutation in Human Cells Exposed to Nitric Oxide in vitro

Proceedings of the National Academy of Sciences - PNAS, 1992-04, Vol.89 (7), p.3030-3034

1992

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Human cytochrome P4502B6: interindividual hepatic expression, substrate specificity, and role in procarcinogen activation

Drug metabolism and disposition, 1997-08, Vol.25 (8), p.985

1997

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Human-Cell Mutagens in Respirable Airborne Particles in the Northeastern United States. 1. Mutagenicity of Fractionated Samples

Environmental science & technology, 2004-02, Vol.38 (3), p.682-689

2004

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A High-Throughput Screen to Identify Inhibitors of Aromatase (CYP19)

Analytical biochemistry, 2000-09, Vol.284 (2), p.427-430

2000

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Comparison of Species Differences of P-Glycoproteins in Beagle Dog, Rhesus Monkey, and Human Using ATPase Activity Assays

Molecular pharmaceutics, 2006-01, Vol.3 (1), p.78-86

2006

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Bioassay-Directed Chemical Analysis of Los Angeles Airborne Particulate Matter Using a Human Cell Mutagenicity Assay

Environmental science & technology, 1998-11, Vol.32 (22), p.3502-3514

1998

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Human cytochrome p450 induction and inhibition potential of clevidipine and its primary metabolite h152/81

Drug metabolism and disposition, 2006-05, Vol.34 (5), p.734-737

2006

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Specific dehydrogenation of 3-methylindole and epoxidation of naphthalene by recombinant human CYP2F1 expressed in lymphoblastoid cells

Drug metabolism and disposition, 1999-07, Vol.27 (7), p.798

1999

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Fluorometric screening for metabolism-based drug–drug interactions

Journal of pharmacological and toxicological methods, 2000-07, Vol.44 (1), p.325-331

2000

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Study of the Pygmy Dipole Resonance in super(124)Sn with AGATA

Journal of physics. Conference series, 2015-01, Vol.580, p.1-5

2015

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Quantitative RT-PCR Measurement of Cytochromes p450 1A1, 1B1, and 2B7, Microsomal Epoxide Hydrolase, and NADPH Oxidoreductase Expression in Lung Cells of Smokers and Nonsmokers

American journal of respiratory cell and molecular biology, 1997-07, Vol.17 (1), p.114-124

1997

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A tobacco smoke-derived nitrosamine, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone, is activated by multiple human cytochrome P450s including the polymorphic human cytochrome P4502D6

Carcinogenesis (New York), 1991-07, Vol.12 (7), p.1197-1201

1991

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The role of 12 cDNA-expressed human, rodent, and rabbit cytochromes P450 in the metabolism of benzo[a]pyrene and benzo[a]pyrene trans-7, 8-dihydrodiol

Molecular carcinogenesis, 1994-07, Vol.10 (3), p.159-168

1994

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Development of a substrate-activity based approach to identify the major human liver P-450 catalysts of cyclophosphamide and ifosfamide activation based on cDNA-expressed activities and liver microsomal P-450 profiles

Substrate-dependent modulation of CYP3A4 catalytic activity: analysis of 27 test compounds with four fluorometric substrates

Cytochrome P450 fluorometric substrates: identification of isoform-selective probes for rat CYP2D2 and human CYP3A4

Design and application of fluorometric assays for human cytochrome P450 inhibition

CYP2C8 polymorphisms in Caucasians and their relationship with paclitaxel 6α-hydroxylase activity in human liver microsomes

CYP3A4 allelic variants with amino acid substitutions in exons 7 and 12: Evidence for an allelic variant with altered catalytic activity

Microtiter Plate Assays for Inhibition of Human, Drug-Metabolizing Cytochromes P450

Comparison between cytochrome P450 (CYP) content and relative activity approaches to scaling from cDNA-expressed CYPs to human liver microsomes: ratios of accessory proteins as sources of discrepancies between the approaches

Effect of methanol, ethanol, dimethyl sulfoxide, and acetonitrile on in vitro activities of cDNA-expressed human cytochromes P-450

The use of heterologously expressed drug metabolizing enzymes— state of the art and prospects for the future

HIGHLY SELECTIVE INHIBITION OF HUMAN CYP3A IN VITRO BY AZAMULIN AND EVIDENCE THAT INHIBITION IS IRREVERSIBLE

Metabolism: a bottleneck in in vitro toxicological test development. The report and recommendations of ECVAM workshop 54

DNA Damage and Mutation in Human Cells Exposed to Nitric Oxide in vitro

Human cytochrome P4502B6: interindividual hepatic expression, substrate specificity, and role in procarcinogen activation

Human-Cell Mutagens in Respirable Airborne Particles in the Northeastern United States. 1. Mutagenicity of Fractionated Samples

A High-Throughput Screen to Identify Inhibitors of Aromatase (CYP19)

Comparison of Species Differences of P-Glycoproteins in Beagle Dog, Rhesus Monkey, and Human Using ATPase Activity Assays

Bioassay-Directed Chemical Analysis of Los Angeles Airborne Particulate Matter Using a Human Cell Mutagenicity Assay

Human cytochrome p450 induction and inhibition potential of clevidipine and its primary metabolite h152/81

Specific dehydrogenation of 3-methylindole and epoxidation of naphthalene by recombinant human CYP2F1 expressed in lymphoblastoid cells

Fluorometric screening for metabolism-based drug–drug interactions

Study of the Pygmy Dipole Resonance in super(124)Sn with AGATA

Quantitative RT-PCR Measurement of Cytochromes p450 1A1, 1B1, and 2B7, Microsomal Epoxide Hydrolase, and NADPH Oxidoreductase Expression in Lung Cells of Smokers and Nonsmokers

A tobacco smoke-derived nitrosamine, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone, is activated by multiple human cytochrome P450s including the polymorphic human cytochrome P4502D6

The role of 12 cDNA-expressed human, rodent, and rabbit cytochromes P450 in the metabolism of benzo[a]pyrene and benzo[a]pyrene trans-7, 8-dihydrodiol

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