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Structure elucidation of colibactin and its DNA cross-links

Science (American Association for the Advancement of Science), 2019-09, Vol.365 (6457)

2019

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Comparative Metabolomics and Structural Characterizations Illuminate Colibactin Pathway-Dependent Small Molecules

Journal of the American Chemical Society, 2014-07, Vol.136 (26), p.9244-9247

2014

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Dual Targeting of v-ATPase and mTORC1 Signaling Disarms Multidrug-Resistant Cancers

Cell chemical biology, 2020-11, Vol.27 (11), p.1329-1331

2020

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Mucosal sugars delineate pyrazine vs pyrazinone autoinducer signaling in Klebsiella oxytoca

Nature communications, 2024-10, Vol.15 (1), p.8902-17, Article 8902

2024

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A Mechanistic Model for Colibactin-Induced Genotoxicity

Journal of the American Chemical Society, 2016-12, Vol.138 (48), p.15563-15570

2016

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Metabolite exchange between microbiome members produces compounds that influence Drosophila behavior

eLife, 2017-01, Vol.6

2017

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Gut symbionts from distinct hosts exhibit genotoxic activity via divergent colibactin biosynthesis pathways

Applied and Environmental Microbiology, 2015-02, Vol.81 (4), p.1502-1512

2015

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Linking Biosynthetic Gene Clusters to their Metabolites via Pathway- Targeted Molecular Networking

Current topics in medicinal chemistry, 2016-06, Vol.16 (15), p.1705-1716

2016

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Characterization of Natural Colibactin–Nucleobase Adducts by Tandem Mass Spectrometry and Isotopic Labeling. Support for DNA Alkylation by Cyclopropane Ring Opening

Biochemistry (Easton), 2018-11, Vol.57 (45), p.6391-6394

2018

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Gut microbes modulate (p)ppGpp during a time-restricted feeding regimen

mBio, 2023-12, Vol.14 (6), p.e0190723

2023

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Small molecule perimeter defense in entomopathogenic bacteria

Proceedings of the National Academy of Sciences - PNAS, 2012-07, Vol.109 (27), p.10821-10826

2012

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Synthesis and reactivity of precolibactin 886

Nature chemistry, 2019-10, Vol.11 (10), p.890-898

2019

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Convergent and Modular Synthesis of Candidate Precolibactins. Structural Revision of Precolibactin A

Journal of the American Chemical Society, 2016-04, Vol.138 (16), p.5426-5432

2016

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An Ugi-like Biosynthetic Pathway Encodes Bombesin Receptor Subtype‑3 Agonists

Journal of the American Chemical Society, 2019-10, Vol.141 (41), p.16271-16278

2019

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Activating and Attenuating the Amicoumacin Antibiotics

Molecules (Basel, Switzerland), 2016-06, Vol.21 (7), p.824-824

2016

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Domain-Targeted Metabolomics Delineates the Heterocycle Assembly Steps of Colibactin Biosynthesis

Journal of the American Chemical Society, 2017-03, Vol.139 (11), p.4195-4201

2017

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Characterization of Autoinducer‑3 Structure and Biosynthesis in E. coli

ACS central science, 2020-02, Vol.6 (2), p.197-206

2020

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Structural basis for biosynthetic programming of fungal aromatic polyketide cyclization

Nature (London), 2009-10, Vol.461 (7267), p.1139-1143

2009

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Pyrazinone protease inhibitor metabolites from Photorhabdus luminescens

Journal of antibiotics, 2016-08, Vol.69 (8), p.616-621

2016

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Introducing THOR, a Model Microbiome for Genetic Dissection of Community Behavior

mBio, 2019-03, Vol.10 (2)

2019

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Deconstruction of Iterative Multidomain Polyketide Synthase Function

Science (American Association for the Advancement of Science), 2008-04, Vol.320 (5873), p.243-246

2008

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Structure and function of an iterative polyketide synthase thioesterase domain catalyzing Claisen cyclization in aflatoxin biosynthesis

Proceedings of the National Academy of Sciences - PNAS, 2010-04, Vol.107 (14), p.6246-6251

2010

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Bacterial small molecule metabolites implicated in gastrointestinal cancer development

Nature reviews. Microbiology, 2024-10

2024

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The colibactin warhead crosslinks DNA

Nature chemistry, 2015-05, Vol.7 (5), p.411-417

2015

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Model Colibactins Exhibit Human Cell Genotoxicity in the Absence of Host Bacteria

ACS chemical biology, 2018-12, Vol.13 (12), p.3286-3293

2018

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Structure elucidation of colibactin and its DNA cross-links

Comparative Metabolomics and Structural Characterizations Illuminate Colibactin Pathway-Dependent Small Molecules

Dual Targeting of v-ATPase and mTORC1 Signaling Disarms Multidrug-Resistant Cancers

Mucosal sugars delineate pyrazine vs pyrazinone autoinducer signaling in Klebsiella oxytoca

A Mechanistic Model for Colibactin-Induced Genotoxicity

Metabolite exchange between microbiome members produces compounds that influence Drosophila behavior

Gut symbionts from distinct hosts exhibit genotoxic activity via divergent colibactin biosynthesis pathways

Linking Biosynthetic Gene Clusters to their Metabolites via Pathway- Targeted Molecular Networking

Characterization of Natural Colibactin–Nucleobase Adducts by Tandem Mass Spectrometry and Isotopic Labeling. Support for DNA Alkylation by Cyclopropane Ring Opening

Gut microbes modulate (p)ppGpp during a time-restricted feeding regimen

Small molecule perimeter defense in entomopathogenic bacteria

Synthesis and reactivity of precolibactin 886

Convergent and Modular Synthesis of Candidate Precolibactins. Structural Revision of Precolibactin A

An Ugi-like Biosynthetic Pathway Encodes Bombesin Receptor Subtype‑3 Agonists

Activating and Attenuating the Amicoumacin Antibiotics

Domain-Targeted Metabolomics Delineates the Heterocycle Assembly Steps of Colibactin Biosynthesis

Characterization of Autoinducer‑3 Structure and Biosynthesis in E. coli

Structural basis for biosynthetic programming of fungal aromatic polyketide cyclization

Pyrazinone protease inhibitor metabolites from Photorhabdus luminescens

Introducing THOR, a Model Microbiome for Genetic Dissection of Community Behavior

Deconstruction of Iterative Multidomain Polyketide Synthase Function

Structure and function of an iterative polyketide synthase thioesterase domain catalyzing Claisen cyclization in aflatoxin biosynthesis

Bacterial small molecule metabolites implicated in gastrointestinal cancer development

The colibactin warhead crosslinks DNA

Model Colibactins Exhibit Human Cell Genotoxicity in the Absence of Host Bacteria

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