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Cryo-EM structures of the TMEM16A calcium-activated chloride channel

Nature (London), 2017-12, Vol.552 (7685), p.426-429

2017

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Proteases as therapeutics

Biochemical journal, 2011-04, Vol.435 (1), p.1-16

2011

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Mapping the catalytic conformations of an assembly-line polyketide synthase module

Science (American Association for the Advancement of Science), 2021-11, Vol.374 (6568), p.729-734

2021

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Characterising proteolysis during SARS-CoV-2 infection identifies viral cleavage sites and cellular targets with therapeutic potential

Nature communications, 2021-09, Vol.12 (1), p.5553-5553, Article 5553

2021

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Structure- and function-based design of Plasmodium-selective proteasome inhibitors

Nature (London), 2016-02, Vol.530 (7589), p.233-236

2016

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Progranulin Stimulates the In Vitro Maturation of Pro-Cathepsin D at Acidic pH

Journal of molecular biology, 2019-03, Vol.431 (5), p.1038-1047

2019

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Quantitative MS-based enzymology of caspases reveals distinct protein substrate specificities, hierarchies, and cellular roles

Proceedings of the National Academy of Sciences - PNAS, 2016-04, Vol.113 (14), p.E2001-E2010

2016

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Mechanisms of Macromolecular Protease Inhibitors

Chembiochem : a European journal of chemical biology, 2010-11, Vol.11 (17), p.2341-2346

2010

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Combination of Antifungal Drugs and Protease Inhibitors Prevent Candida albicans Biofilm Formation and Disrupt Mature Biofilms

Frontiers in microbiology, 2020-05, Vol.11, p.1027-1027

2020

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Subnanometre-resolution electron cryomicroscopy structure of a heterodimeric ABC exporter

Nature (London), 2015-01, Vol.517 (7534), p.396-400

2015

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Predicting CD4 T-cell epitopes based on antigen cleavage, MHCII presentation, and TCR recognition

PloS one, 2018-11, Vol.13 (11), p.e0206654-e0206654

2018

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Assessment of human virus removal during municipal wastewater treatment in Edmonton, Canada

Journal of applied microbiology, 2015-12, Vol.119 (6), p.1729-1739

2015

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Global substrate profiling of proteases in human neutrophil extracellular traps reveals consensus motif predominantly contributed by elastase

PloS one, 2013-09, Vol.8 (9), p.e75141-e75141

2013

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Substrate Profiling of Cysteine Proteases Using a Combinatorial Peptide Library Identifies Functionally Unique Specificities

The Journal of biological chemistry, 2006-05, Vol.281 (18), p.12824-12832

2006

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Phosphorylation of tau at a single residue inhibits binding to the E3 ubiquitin ligase, CHIP

Nature communications, 2024-09, Vol.15 (1), p.7972-15, Article 7972

2024

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Structural requirements for the collagenase and elastase activity of cathepsin K and its selective inhibition by an exosite inhibitor

Biochemical journal, 2015-01, Vol.465 (1), p.163-173

2015

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Structural and mechanistic basis of the EMC-dependent biogenesis of distinct transmembrane clients

eLife, 2020-11, Vol.9

2020

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Continuous Imaging of Plasmon Rulers in Live Cells Reveals Early-Stage Caspase-3 Activation at the Single-Molecule Level

Proceedings of the National Academy of Sciences - PNAS, 2009-10, Vol.106 (42), p.17735-17740

2009

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Re-emerging Aspartic Protease Targets: Examining Cryptococcus neoformans Major Aspartyl Peptidase 1 as a Target for Antifungal Drug Discovery

Journal of medicinal chemistry, 2021-05, Vol.64 (10), p.6706-6719

2021

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Vinyl Sulfones as Antiparasitic Agents and a Structural Basis for Drug Design

The Journal of biological chemistry, 2009-09, Vol.284 (38), p.25697-25703

2009

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Structure–Function Analysis of the Extended Conformation of a Polyketide Synthase Module

Journal of the American Chemical Society, 2018-05, Vol.140 (21), p.6518-6521

2018

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Structure-function analysis of enterovirus protease 2A in complex with its essential host factor SETD3

Nature communications, 2022-09, Vol.13 (1), p.5282-5282, Article 5282

2022

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Matriptase activation connects tissue factor–dependent coagulation initiation to epithelial proteolysis and signaling

Blood, 2016-06, Vol.127 (25), p.3260-3269

2016

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Integrated Activity and Genetic Profiling of Secreted Peptidases in Cryptococcus neoformans Reveals an Aspartyl Peptidase Required for Low pH Survival and Virulence

PLoS pathogens, 2016-12, Vol.12 (12), p.e1006051-e1006051

2016

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Global Identification of Biofilm-Specific Proteolysis in Candida albicans

mBio, 2016-09, Vol.7 (5)

2016

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Cryo-EM structures of the TMEM16A calcium-activated chloride channel

Proteases as therapeutics

Mapping the catalytic conformations of an assembly-line polyketide synthase module

Characterising proteolysis during SARS-CoV-2 infection identifies viral cleavage sites and cellular targets with therapeutic potential

Structure- and function-based design of Plasmodium-selective proteasome inhibitors

Progranulin Stimulates the In Vitro Maturation of Pro-Cathepsin D at Acidic pH

Quantitative MS-based enzymology of caspases reveals distinct protein substrate specificities, hierarchies, and cellular roles

Mechanisms of Macromolecular Protease Inhibitors

Combination of Antifungal Drugs and Protease Inhibitors Prevent Candida albicans Biofilm Formation and Disrupt Mature Biofilms

Subnanometre-resolution electron cryomicroscopy structure of a heterodimeric ABC exporter

Predicting CD4 T-cell epitopes based on antigen cleavage, MHCII presentation, and TCR recognition

Assessment of human virus removal during municipal wastewater treatment in Edmonton, Canada

Global substrate profiling of proteases in human neutrophil extracellular traps reveals consensus motif predominantly contributed by elastase

Substrate Profiling of Cysteine Proteases Using a Combinatorial Peptide Library Identifies Functionally Unique Specificities

Phosphorylation of tau at a single residue inhibits binding to the E3 ubiquitin ligase, CHIP

Structural requirements for the collagenase and elastase activity of cathepsin K and its selective inhibition by an exosite inhibitor

Structural and mechanistic basis of the EMC-dependent biogenesis of distinct transmembrane clients

Continuous Imaging of Plasmon Rulers in Live Cells Reveals Early-Stage Caspase-3 Activation at the Single-Molecule Level

Re-emerging Aspartic Protease Targets: Examining Cryptococcus neoformans Major Aspartyl Peptidase 1 as a Target for Antifungal Drug Discovery

Vinyl Sulfones as Antiparasitic Agents and a Structural Basis for Drug Design

Structure–Function Analysis of the Extended Conformation of a Polyketide Synthase Module

Structure-function analysis of enterovirus protease 2A in complex with its essential host factor SETD3

Matriptase activation connects tissue factor–dependent coagulation initiation to epithelial proteolysis and signaling

Integrated Activity and Genetic Profiling of Secreted Peptidases in Cryptococcus neoformans Reveals an Aspartyl Peptidase Required for Low pH Survival and Virulence

Global Identification of Biofilm-Specific Proteolysis in Candida albicans

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