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Could AlphaFold revolutionize chemical therapeutics?

Nature structural & molecular biology, 2021-10, Vol.28 (10), p.771-772

2021

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Immunoglobulin E Signal Inhibition during Allergen Ingestion Leads to Reversal of Established Food Allergy and Induction of Regulatory T Cells

Immunity (Cambridge, Mass.), 2014-07, Vol.41 (1), p.141-151

2014

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Phenotypic responses of differentiated asthmatic human airway epithelial cultures to rhinovirus

PloS one, 2015-02, Vol.10 (2), p.e0118286-e0118286

2015

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Temporally Regulated and Tissue-Specific Gene Manipulations in the Adult and Embryonic Heart Using a Tamoxifen-Inducible Cre Protein

Circulation research, 2001-07, Vol.89 (1), p.20-25

2001

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Advances toward structure-based drug discovery for inflammasome targets

The Journal of experimental medicine, 2022-01, Vol.219 (1)

2022

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Regulation of Myocardial Contractility and Cell Size by Distinct PI3K-PTEN Signaling Pathways

Cell, 2002-09, Vol.110 (6), p.737-749

2002

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Gene expression profiling following NRF2 and KEAP1 siRNA knockdown in human lung fibroblasts identifies CCL11/Eotaxin-1 as a novel NRF2 regulated gene

Respiratory research, 2012-10, Vol.13 (1), p.92-92, Article 92

2012

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A human tissue-based functional assay platform to evaluate the immune function impact of small molecule inhibitors that target the immune system

PloS one, 2017-07, Vol.12 (7), p.e0180870-e0180870

2017

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The Role of ACE2 in Cardiovascular Physiology

Trends in Cardiovascular Medicine, 2003-04, Vol.13 (3), p.93-101

2003

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Essential Role of Fkbp6 in Male Fertility and Homologous Chromosome Pairing in Meiosis

Science (American Association for the Advancement of Science), 2003-05, Vol.300 (5623), p.1291-1295

2003

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Mice with a Targeted Mutation of Patched2 Are Viable but Develop Alopecia and Epidermal Hyperplasia

Molecular and Cellular Biology, 2006-09, Vol.26 (17), p.6609-6622

2006

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Angiotensin-converting enzyme 2 protects from severe acute lung failure

Nature, 2005-07, Vol.436 (7047), p.112-116

2005

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The use of strictly standardized mean difference for hit selection in primary RNA interference high-throughput screening experiments

Journal of biomolecular screening, 2007-06, Vol.12 (4), p.497-509

2007

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The role of phosphoinositide-3 kinase and PTEN in cardiovascular physiology and disease

Journal of Molecular and Cellular Cardiology, 2004-08, Vol.37 (2), p.449-471

2004

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Systems analysis of eleven rodent disease models reveals an inflammatome signature and key drivers

Molecular systems biology, 2012-07, Vol.8 (1), p.594-n/a

2012

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Loss of Angiotensin-Converting Enzyme-2 Leads to the Late Development of Angiotensin II-Dependent Glomerulosclerosis

The American journal of pathology, 2006-06, Vol.168 (6), p.1808-1820

2006

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Angiotensin-converting enzyme 2 is an essential regulator of heart function

Nature (London), 2002-06, Vol.417 (6891), p.822-828

2002

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Inhibition of α v β 5 Integrin Attenuates Vascular Permeability and Protects against Renal Ischemia-Reperfusion Injury

Journal of the American Society of Nephrology, 2017-06, Vol.28 (6), p.1741

2017

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Mutant meiotic chromosome core components in mice can cause apparent sexual dimorphic endpoints at prophase or X-Y defective male-specific sterility

Chromosoma, 2005-07, Vol.114 (2), p.92-102

2005

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Inhibition of spleen tyrosine kinase attenuates IgE‐mediated airway contraction and mediator release in human precision cut lung slices

British journal of pharmacology, 2016-11, Vol.173 (21), p.3080-3087

2016

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Loss of PTEN attenuates the development of pathological hypertrophy and heart failure in response to biomechanical stress

Cardiovascular research, 2008-06, Vol.78 (3), p.505-514

2008

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Pharmacological characterization of MK-7246, a potent and selective CRTH2 (chemoattractant receptor-homologous molecule expressed on T-helper type 2 cells) antagonist

Molecular pharmacology, 2011-01, Vol.79 (1), p.69-76

2011

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Inhibition of spleen tyrosine kinase attenuates allergen-mediated airway constriction

American journal of respiratory cell and molecular biology, 2013-12, Vol.49 (6), p.1085-1092

2013

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Phosphoinositide 3-kinase γ-deficient mice are protected from isoproterenol-induced heart failure

Circulation (New York, N.Y.), 2003-10, Vol.108 (17), p.2147-2152

2003

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Inhibition of αvβ5 Integrin Attenuates Vascular Permeability and Protects against Renal Ischemia-Reperfusion Injury

Journal of the American Society of Nephrology, 2017-06, Vol.28 (6), p.1741-1752

2017

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Could AlphaFold revolutionize chemical therapeutics?

Immunoglobulin E Signal Inhibition during Allergen Ingestion Leads to Reversal of Established Food Allergy and Induction of Regulatory T Cells

Phenotypic responses of differentiated asthmatic human airway epithelial cultures to rhinovirus

Temporally Regulated and Tissue-Specific Gene Manipulations in the Adult and Embryonic Heart Using a Tamoxifen-Inducible Cre Protein

Advances toward structure-based drug discovery for inflammasome targets

Regulation of Myocardial Contractility and Cell Size by Distinct PI3K-PTEN Signaling Pathways

Gene expression profiling following NRF2 and KEAP1 siRNA knockdown in human lung fibroblasts identifies CCL11/Eotaxin-1 as a novel NRF2 regulated gene

A human tissue-based functional assay platform to evaluate the immune function impact of small molecule inhibitors that target the immune system

The Role of ACE2 in Cardiovascular Physiology

Essential Role of Fkbp6 in Male Fertility and Homologous Chromosome Pairing in Meiosis

Mice with a Targeted Mutation of Patched2 Are Viable but Develop Alopecia and Epidermal Hyperplasia

Angiotensin-converting enzyme 2 protects from severe acute lung failure

The use of strictly standardized mean difference for hit selection in primary RNA interference high-throughput screening experiments

The role of phosphoinositide-3 kinase and PTEN in cardiovascular physiology and disease

Systems analysis of eleven rodent disease models reveals an inflammatome signature and key drivers

Loss of Angiotensin-Converting Enzyme-2 Leads to the Late Development of Angiotensin II-Dependent Glomerulosclerosis

Angiotensin-converting enzyme 2 is an essential regulator of heart function

Inhibition of α v β 5 Integrin Attenuates Vascular Permeability and Protects against Renal Ischemia-Reperfusion Injury

Mutant meiotic chromosome core components in mice can cause apparent sexual dimorphic endpoints at prophase or X-Y defective male-specific sterility

Inhibition of spleen tyrosine kinase attenuates IgE‐mediated airway contraction and mediator release in human precision cut lung slices

Loss of PTEN attenuates the development of pathological hypertrophy and heart failure in response to biomechanical stress

Pharmacological characterization of MK-7246, a potent and selective CRTH2 (chemoattractant receptor-homologous molecule expressed on T-helper type 2 cells) antagonist

Inhibition of spleen tyrosine kinase attenuates allergen-mediated airway constriction

Phosphoinositide 3-kinase γ-deficient mice are protected from isoproterenol-induced heart failure

Inhibition of αvβ5 Integrin Attenuates Vascular Permeability and Protects against Renal Ischemia-Reperfusion Injury

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