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Discovery of a class of highly potent Janus Kinase 1/2 (JAK1/2) inhibitors demonstrating effective cell-based blockade of IL-13 signaling

Bioorganic & medicinal chemistry letters, 2019-06, Vol.29 (12), p.1522-1531

2019

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Novel triazolo-pyrrolopyridines as inhibitors of Janus kinase 1

Bioorganic & medicinal chemistry letters, 2013-06, Vol.23 (12), p.3592-3598

2013

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1H-Pyrazolo[3,4-g]hexahydro-isoquinolines as selective glucocorticoid receptor antagonists with high functional activity

Bioorganic & medicinal chemistry, 2008-02, Vol.18 (4), p.1312-1317

2008

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Studies toward the Large-Scale Synthesis of the HIV Proteinase Inhibitor Ro 31-8959

Journal of organic chemistry, 1994-07, Vol.59 (13), p.3656-3664

1994

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Identification and optimisation of a series of substituted 5-(1 H-pyrazol-3-yl)-thiophene-2-hydroxamic acids as potent histone deacetylase (HDAC) inhibitors

Bioorganic & medicinal chemistry letters, 2007-01, Vol.17 (2), p.370-375

2007

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Discovery and optimization of novel, non-steroidal glucocorticoid receptor modulators

Bioorganic & medicinal chemistry letters, 2007-09, Vol.17 (17), p.4901-4905

2007

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2-Benzenesulfonyl-8a-benzyl-hexahydro-2H-isoquinolin-6-ones as selective glucocorticoid receptor antagonists

Bioorganic & medicinal chemistry letters, 2007-10, Vol.17 (20), p.5704-5708

2007

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1 H-Pyrazolo[3,4- g]hexahydro-isoquinolines as selective glucocorticoid receptor antagonists with high functional activity

Bioorganic & medicinal chemistry letters, 2008, Vol.18 (4), p.1312-1317

2008

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Asymmetric synthesis via acetal templates. 9. Further studies of the allylation reaction. Preparation of (−)-dihydromyoporone

Tetrahedron letters, 1984, Vol.25 (36), p.3951-3954

1984

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Total synthesis of analogues of the β-lactam antibiotics. Part 6. (6R)-4(t-butoxycarbonyl)-2-methoxycarbonyl-3-oxacepham 1,1-dioxides

J. Chem. Soc., Perkin Trans. 1, 1991 (5), p.1235-1243

1991

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Total synthesis of analogues of the β-lactam antibiotics. Part 5. 3-Thiacepham-4-exo-carboxylates and their 1,1,3,3-tetraoxides

J. Chem. Soc., Perkin Trans. 1, 1990 (3), p.773-781

1990

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Total synthesis of analogues of the β-lactam antibiotics. Part 2. Isopenam-3-carboxylates and their 2,2-dioxides

J. Chem. Soc., Perkin Trans. 1, 1984, p.2785-2793

1984

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A convenient synthesis of bisindolylmaleimides

Tetrahedron letters, 1993-08, Vol.34 (35), p.5623-5626

1993

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β-Lactam-cleavage reactions of isopenam-3-carboxylates and their 2,2-dioxides

Journal of the Chemical Society. Chemical communications, 1983 (22), p.1284-1286

1983

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Synthesis of racemic 3-thiacepham-4-carboxylates and their 1,1,3,3-tetroxides

Journal of the Chemical Society. Chemical communications, 1983 (16), p.917

1983

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Some observations regarding β-lactam-cleavage reactions of penicillanate 1,1-dioxides and related compounds

Tetrahedron letters, 1984, Vol.25 (12), p.1295-1298

1984

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Complexes of imidazoline (1,3H)-2-thione with Co(II) and Zn(II) salts

Inorganica Chimica Acta, 1981, Vol.50, p.159-165

1981

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Synthesis of 2-(methoxycarbonyl)methyl-7-phenylacetamido-3-thiacepham-4-carboxylates

Tetrahedron letters, 1986, Vol.27 (11), p.1301-1304

1986

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Design, synthesis and characterization of a novel class of coumarin-based inhibitors of inducible nitric oxide synthase

Bioorganic & medicinal chemistry, 2005-04, Vol.13 (8), p.2723-2739

2005

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Discovery of a class of highly potent Janus Kinase 1/2 (JAK1/2) inhibitors demonstrating effective cell-based blockade of IL-13 signaling

Novel triazolo-pyrrolopyridines as inhibitors of Janus kinase 1

1H-Pyrazolo[3,4-g]hexahydro-isoquinolines as selective glucocorticoid receptor antagonists with high functional activity

Studies toward the Large-Scale Synthesis of the HIV Proteinase Inhibitor Ro 31-8959

Identification and optimisation of a series of substituted 5-(1 H-pyrazol-3-yl)-thiophene-2-hydroxamic acids as potent histone deacetylase (HDAC) inhibitors

Discovery and optimization of novel, non-steroidal glucocorticoid receptor modulators

2-Benzenesulfonyl-8a-benzyl-hexahydro-2H-isoquinolin-6-ones as selective glucocorticoid receptor antagonists

1 H-Pyrazolo[3,4- g]hexahydro-isoquinolines as selective glucocorticoid receptor antagonists with high functional activity

Asymmetric synthesis via acetal templates. 9. Further studies of the allylation reaction. Preparation of (−)-dihydromyoporone

Total synthesis of analogues of the β-lactam antibiotics. Part 6. (6R)-4(t-butoxycarbonyl)-2-methoxycarbonyl-3-oxacepham 1,1-dioxides

Total synthesis of analogues of the β-lactam antibiotics. Part 5. 3-Thiacepham-4-exo-carboxylates and their 1,1,3,3-tetraoxides

Total synthesis of analogues of the β-lactam antibiotics. Part 2. Isopenam-3-carboxylates and their 2,2-dioxides

A convenient synthesis of bisindolylmaleimides

β-Lactam-cleavage reactions of isopenam-3-carboxylates and their 2,2-dioxides

Synthesis of racemic 3-thiacepham-4-carboxylates and their 1,1,3,3-tetroxides

Some observations regarding β-lactam-cleavage reactions of penicillanate 1,1-dioxides and related compounds

Complexes of imidazoline (1,3H)-2-thione with Co(II) and Zn(II) salts

Synthesis of 2-(methoxycarbonyl)methyl-7-phenylacetamido-3-thiacepham-4-carboxylates

Design, synthesis and characterization of a novel class of coumarin-based inhibitors of inducible nitric oxide synthase

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