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Nitric Oxide Modulates Metabolic Remodeling in Inflammatory Macrophages through TCA Cycle Regulation and Itaconate Accumulation

Cell reports (Cambridge), 2019-07, Vol.28 (1), p.218-230.e7

2019

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Synthesis and recycling of tetrahydrobiopterin in endothelial function and vascular disease

Nitric oxide, 2011-08, Vol.25 (2), p.81-88

2011

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Regulation of iNOS function and cellular redox state by macrophage Gch1 reveals specific requirements for tetrahydrobiopterin in NRF2 activation

Free radical biology & medicine, 2015-02, Vol.79, p.206-216

2015

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Isolation and culture of murine bone marrow-derived macrophages for nitric oxide and redox biology

Nitric oxide, 2020-08, Vol.100-101, p.17-29

2020

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Dihydrofolate reductase protects endothelial nitric oxide synthase from uncoupling in tetrahydrobiopterin deficiency

Free radical biology & medicine, 2011-06, Vol.50 (11), p.1639-1646

2011

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Integrated Redox Sensor and Effector Functions for Tetrahydrobiopterin- and Glutathionylation-dependent Endothelial Nitric-oxide Synthase Uncoupling

The Journal of biological chemistry, 2013-01, Vol.288 (1), p.561-569

2013

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Endothelial Cell-Specific Reactive Oxygen Species Production Increases Susceptibility to Aortic Dissection

Circulation (New York, N.Y.), 2014-06, Vol.129 (25), p.2661-2672

2014

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Gene therapy targeting inflammation in atherosclerosis

Current pharmaceutical design, 2011-12, Vol.17 (37), p.4210-4223

2011

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Endothelial-specific Nox2 overexpression increases vascular superoxide and macrophage recruitment in ApoE―/― mice

Cardiovascular research, 2012-04, Vol.94 (1), p.20-29

2012

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Recoupling the Cardiac Nitric Oxide Synthases: Tetrahydrobiopterin Synthesis and Recycling

Current heart failure reports, 2012-09, Vol.9 (3), p.200-210

2012

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Cardiomyocyte tetrahydrobiopterin synthesis regulates fatty acid metabolism and susceptibility to ischaemia–reperfusion injury

Experimental physiology, 2023-06, Vol.108 (6), p.874-890

2023

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Cell-Autonomous Role of Endothelial GTP Cyclohydrolase 1 and Tetrahydrobiopterin in Blood Pressure Regulation

Hypertension (Dallas, Tex. 1979), 2014-09, Vol.64 (3), p.530-540

2014

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Regulation of mycobacterial infection by macrophage Gch1 and tetrahydrobiopterin

Nature communications, 2018-12, Vol.9 (1), p.5409-16, Article 5409

2018

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Protection against ventricular fibrillation via cholinergic receptor stimulation and the generation of nitric oxide

The Journal of physiology, 2016-07, Vol.594 (14), p.3981-3992

2016

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CAPON Modulates Neuronal Calcium Handling and Cardiac Sympathetic Neurotransmission During Dysautonomia in Hypertension

Hypertension (Dallas, Tex. 1979), 2015-06, Vol.65 (6), p.1288-1297

2015

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Gene delivery strategies targeting stable atheromatous plaque

Current pharmaceutical design, 2013-03, Vol.19 (9), p.1626-1637

2013

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Tetrahydrobiopterin in cardiovascular health and disease

Antioxidants & redox signaling, 2014-06, Vol.20 (18), p.3040-3077

2014

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Hyperglycemia Induces Trained Immunity in Macrophages and Their Precursors and Promotes Atherosclerosis

Circulation (New York, N.Y.), 2021-09, Vol.144 (12), p.961-982

2021

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Biological Sensing of Nitric Oxide in Macrophages and Atherosclerosis Using a Ruthenium-Based Sensor

Biomedicines, 2022-07, Vol.10 (8), p.1807

2022

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Cardiomyocyte GTP Cyclohydrolase 1 and Tetrahydrobiopterin Increase NOS1 Activity and Accelerate Myocardial Relaxation

Circulation research, 2012-08, Vol.111 (6), p.718-727

2012

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Nitric oxide synthases in heart failure

Antioxidants & redox signaling, 2013-03, Vol.18 (9), p.1078-1099

2013

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Itaconate as an inflammatory mediator and therapeutic target in cardiovascular medicine

Biochemical Society transactions, 2021-11, Vol.49 (5), p.2189-2198

2021

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GTP Cyclohydrolase I Expression, Protein, and Activity Determine Intracellular Tetrahydrobiopterin Levels, Independent of GTP Cyclohydrolase Feedback Regulatory Protein Expression

The Journal of biological chemistry, 2009-05, Vol.284 (20), p.13660-13668

2009

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Tetrahydrobiopterin supplementation reduces atherosclerosis and vascular inflammation in apolipoprotein E-knockout mice

Clinical science (1979), 2010-08, Vol.119 (3), p.131-142

2010

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Hepatic miR-144 Drives Fumarase Activity Preventing NRF2 Activation During Obesity

Gastroenterology (New York, N.Y. 1943), 2021-12, Vol.161 (6), p.1982-1997.e11

2021

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Nitric Oxide Modulates Metabolic Remodeling in Inflammatory Macrophages through TCA Cycle Regulation and Itaconate Accumulation

Synthesis and recycling of tetrahydrobiopterin in endothelial function and vascular disease

Regulation of iNOS function and cellular redox state by macrophage Gch1 reveals specific requirements for tetrahydrobiopterin in NRF2 activation

Isolation and culture of murine bone marrow-derived macrophages for nitric oxide and redox biology

Dihydrofolate reductase protects endothelial nitric oxide synthase from uncoupling in tetrahydrobiopterin deficiency

Integrated Redox Sensor and Effector Functions for Tetrahydrobiopterin- and Glutathionylation-dependent Endothelial Nitric-oxide Synthase Uncoupling

Endothelial Cell-Specific Reactive Oxygen Species Production Increases Susceptibility to Aortic Dissection

Gene therapy targeting inflammation in atherosclerosis

Endothelial-specific Nox2 overexpression increases vascular superoxide and macrophage recruitment in ApoE―/― mice

Recoupling the Cardiac Nitric Oxide Synthases: Tetrahydrobiopterin Synthesis and Recycling

Cardiomyocyte tetrahydrobiopterin synthesis regulates fatty acid metabolism and susceptibility to ischaemia–reperfusion injury

Cell-Autonomous Role of Endothelial GTP Cyclohydrolase 1 and Tetrahydrobiopterin in Blood Pressure Regulation

Regulation of mycobacterial infection by macrophage Gch1 and tetrahydrobiopterin

Protection against ventricular fibrillation via cholinergic receptor stimulation and the generation of nitric oxide

CAPON Modulates Neuronal Calcium Handling and Cardiac Sympathetic Neurotransmission During Dysautonomia in Hypertension

Gene delivery strategies targeting stable atheromatous plaque

Tetrahydrobiopterin in cardiovascular health and disease

Hyperglycemia Induces Trained Immunity in Macrophages and Their Precursors and Promotes Atherosclerosis

Biological Sensing of Nitric Oxide in Macrophages and Atherosclerosis Using a Ruthenium-Based Sensor

Cardiomyocyte GTP Cyclohydrolase 1 and Tetrahydrobiopterin Increase NOS1 Activity and Accelerate Myocardial Relaxation

Nitric oxide synthases in heart failure

Itaconate as an inflammatory mediator and therapeutic target in cardiovascular medicine

GTP Cyclohydrolase I Expression, Protein, and Activity Determine Intracellular Tetrahydrobiopterin Levels, Independent of GTP Cyclohydrolase Feedback Regulatory Protein Expression

Tetrahydrobiopterin supplementation reduces atherosclerosis and vascular inflammation in apolipoprotein E-knockout mice

Hepatic miR-144 Drives Fumarase Activity Preventing NRF2 Activation During Obesity

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