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Serine is a natural ligand and allosteric activator of pyruvate kinase M2

Nature (London), 2012-11, Vol.491 (7424), p.458-462

2012

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Higher throughput calorimetry: opportunities, approaches and challenges

Current opinion in structural biology, 2010-10, Vol.20 (5), p.598-605

2010

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Structure of the Epigenetic Oncogene MMSET and Inhibition by N‑Alkyl Sinefungin Derivatives

ACS chemical biology, 2016-11, Vol.11 (11), p.3093-3105

2016

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Native Mass Spectrometry Gives Insight into the Allosteric Binding Mechanism of M2 Pyruvate Kinase to Fructose-1,6-Bisphosphate

Biochemistry (Easton), 2018-03, Vol.57 (11), p.1685-1689

2018

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Fragment-Based Drug Discovery Applied to Hsp90. Discovery of Two Lead Series with High Ligand Efficiency

Journal of medicinal chemistry, 2010-08, Vol.53 (16), p.5942-5955

2010

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Exploitation of a Novel Binding Pocket in Human Lipoprotein-Associated Phospholipase A2 (Lp-PLA2) Discovered through X‑ray Fragment Screening

Journal of medicinal chemistry, 2016-06, Vol.59 (11), p.5356-5367

2016

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Fragment-Based Approach to the Development of an Orally Bioavailable Lactam Inhibitor of Lipoprotein-Associated Phospholipase A2 (Lp-PLA2)

Journal of medicinal chemistry, 2016-12, Vol.59 (23), p.10738-10749

2016

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Fragment-Based Discovery of Potent and Selective DDR1/2 Inhibitors

ACS medicinal chemistry letters, 2015-07, Vol.6 (7), p.798-803

2015

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Application of Native ESI-MS to Characterize Interactions between Compounds Derived from Fragment-Based Discovery Campaigns and Two Pharmaceutically Relevant Proteins

SLAS discovery, 2018-10, Vol.23 (9), p.951-959

2018

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Crystal Structure of Human Soluble Adenylate Cyclase Reveals a Distinct, Highly Flexible Allosteric Bicarbonate Binding Pocket

ChemMedChem, 2014-04, Vol.9 (4), p.823-832

2014

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Structure of GABARAP in Two Conformations: Implications for GABAA Receptor Localization and Tubulin Binding

Neuron (Cambridge, Mass.), 2002-01, Vol.33 (1), p.63

2002

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Fragment-Based Discovery of Type I Inhibitors of Maternal Embryonic Leucine Zipper Kinase

ACS medicinal chemistry letters, 2015-01, Vol.6 (1), p.25-30

2015

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Structure of GABARAP in Two Conformations: Implications for GABA A Receptor Localization and Tubulin Binding

Neuron (Cambridge, Mass.), 2002-01, Vol.33 (1), p.63-74

2002

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Structure-Based Design of Type II Inhibitors Applied to Maternal Embryonic Leucine Zipper Kinase

ACS medicinal chemistry letters, 2015-01, Vol.6 (1), p.31-36

2015

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GABARAP: Lessons for Synaptogenesis

The Neuroscientist (Baltimore, Md.), 2003-06, Vol.9 (3), p.205-216

2003

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Structural Plasticity and Noncovalent Substrate Binding in the GroEL Apical Domain

The Journal of biological chemistry, 2002-09, Vol.277 (36), p.33115-33126

2002

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GroEL accelerates the refolding of hen lysozyme without changing its folding mechanism

Nature structural biology, 1999-07, Vol.6 (7), p.683-690

1999

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Corrigendum: serine is a natural ligand and allosteric activator of pyruvate kinase M2

Nature (London), 2013-04, Vol.496 (7445), p.386

2013

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Correction: Corrigendum: Serine is a natural ligand and allosteric activator of pyruvate kinase M2

Nature (London), 2013-04, Vol.496 (7445), p.386-386

2013

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Identification of novel allosteric inhibitors through fragment-based drug discovery and X-ray crystallography

Acta crystallographica. Section A, Foundations and advances, 2015-08, Vol.71 (a1), p.s38-s38

2015

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Serine is a natural ligand and allosteric activator of pyruvate kinase M2

Discovery of (2,4-Dihydroxy-5-isopropylphenyl)-[5-(4-methylpiperazin-1-ylmethyl)-1,3-dihydroisoindol-2-yl]methanone (AT13387), a Novel Inhibitor of the Molecular Chaperone Hsp90 by Fragment Based Drug Design

Higher throughput calorimetry: opportunities, approaches and challenges

Structure of the Epigenetic Oncogene MMSET and Inhibition by N‑Alkyl Sinefungin Derivatives

Monoacidic Inhibitors of the Kelch-like ECH-Associated Protein 1: Nuclear Factor Erythroid 2‑Related Factor 2 (KEAP1:NRF2) Protein–Protein Interaction with High Cell Potency Identified by Fragment-Based Discovery

Structure–Activity and Structure–Conformation Relationships of Aryl Propionic Acid Inhibitors of the Kelch-like ECH-Associated Protein 1/Nuclear Factor Erythroid 2‑Related Factor 2 (KEAP1/NRF2) Protein–Protein Interaction

Native Mass Spectrometry Gives Insight into the Allosteric Binding Mechanism of M2 Pyruvate Kinase to Fructose-1,6-Bisphosphate

Fragment-Based Discovery of a Series of Allosteric-Binding Site Modulators of β‑Glucocerebrosidase

Fragment-Based Drug Discovery Applied to Hsp90. Discovery of Two Lead Series with High Ligand Efficiency

Discovery of ASTX029, A Clinical Candidate Which Modulates the Phosphorylation and Catalytic Activity of ERK1/2

Exploitation of a Novel Binding Pocket in Human Lipoprotein-Associated Phospholipase A2 (Lp-PLA2) Discovered through X‑ray Fragment Screening

Fragment-Based Approach to the Development of an Orally Bioavailable Lactam Inhibitor of Lipoprotein-Associated Phospholipase A2 (Lp-PLA2)

Fragment-Based Discovery of Potent and Selective DDR1/2 Inhibitors

Application of Native ESI-MS to Characterize Interactions between Compounds Derived from Fragment-Based Discovery Campaigns and Two Pharmaceutically Relevant Proteins

Crystal Structure of Human Soluble Adenylate Cyclase Reveals a Distinct, Highly Flexible Allosteric Bicarbonate Binding Pocket

Structure of GABARAP in Two Conformations: Implications for GABAA Receptor Localization and Tubulin Binding

Fragment-Based Discovery of Type I Inhibitors of Maternal Embryonic Leucine Zipper Kinase

Structure of GABARAP in Two Conformations: Implications for GABA A Receptor Localization and Tubulin Binding

Structure-Based Design of Type II Inhibitors Applied to Maternal Embryonic Leucine Zipper Kinase

GABARAP: Lessons for Synaptogenesis

Structural Plasticity and Noncovalent Substrate Binding in the GroEL Apical Domain

GroEL accelerates the refolding of hen lysozyme without changing its folding mechanism

Corrigendum: serine is a natural ligand and allosteric activator of pyruvate kinase M2

Correction: Corrigendum: Serine is a natural ligand and allosteric activator of pyruvate kinase M2

Identification of novel allosteric inhibitors through fragment-based drug discovery and X-ray crystallography

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