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Bisphosphonates: molecular mechanisms of action and effects on bone cells, monocytes and macrophages

Current pharmaceutical design, 2010-09, Vol.16 (27), p.2950-2960

2010

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Cellular and molecular mechanisms of action of bisphosphonates

Cancer, 2000-06, Vol.88 (12), p.2961-2978

2000

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Nitrogen‐Containing Bisphosphonates Inhibit the Mevalonate Pathway and Prevent Post‐Translational Prenylation of GTP‐Binding Proteins, Including Ras

Journal of bone and mineral research, 1998-04, Vol.13 (4), p.581-589

1998

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Protein Geranylgeranylation Is Required for Osteoclast Formation, Function, and Survival: Inhibition by Bisphosphonates and GGTI‐298

Journal of bone and mineral research, 2000-08, Vol.15 (8), p.1467-1476

2000

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The pharmacology of bisphosphonates and new insights into their mechanisms of action

Journal of bone and mineral research, 1999-10, Vol.14 (S2), p.53-65

1999

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Molecular mechanisms of action of bisphosphonates

Bone (New York, N.Y.), 1999-05, Vol.24 (5), p.73S-79S

1999

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Heterocycle‐Containing Bisphosphonates Cause Apoptosis and Inhibit Bone Resorption by Preventing Protein Prenylation: Evidence from Structure‐Activity Relationships in J774 Macrophages

Journal of bone and mineral research, 1998-11, Vol.13 (11), p.1668-1678

1998

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The role of prenylated small GTP-binding proteins in the regulation of osteoclast function

Calcified tissue international, 2003-01, Vol.72 (1), p.80-84

2003

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Bisphosphonates induce apoptosis in mouse macrophage‐like cells in vitro by a nitric oxide‐independent mechanism

Journal of bone and mineral research, 1996-10, Vol.11 (10), p.1482-1491

1996

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Inhibition of Protein Prenylation by Bisphosphonates Causes Sustained Activation of Rac, Cdc42, and Rho GTPases

Journal of bone and mineral research, 2006-05, Vol.21 (5), p.684-694

2006

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Structure-activity relationships for inhibition of farnesyl diphosphate synthase in vitro and inhibition of bone resorption in vivo by nitrogen-containing bisphosphonates

The Journal of pharmacology and experimental therapeutics, 2001-02, Vol.296 (2), p.235

2001

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Phosphonocarboxylate inhibitors of Rab geranylgeranyl transferase disrupt the prenylation and membrane localization of Rab proteins in osteoclasts in vitro and in vivo

Bone (New York, N.Y.), 2005-09, Vol.37 (3), p.349-358

2005

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The citrus flavanone hesperetin decreases osteoclast formation and function in vitro

Proceedings of the Nutrition Society, 2011, Vol.70 (OCE4), Article E132

2011

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Identification of a Novel Phosphonocarboxylate Inhibitor of Rab Geranylgeranyl Transferase That Specifically Prevents Rab Prenylation in Osteoclasts and Macrophages

The Journal of biological chemistry, 2001-12, Vol.276 (51), p.48213-48222

2001

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Visualizing mineral binding and uptake of bisphosphonate by osteoclasts and non-resorbing cells

Bone (New York, N.Y.), 2008-05, Vol.42 (5), p.848-860

2008

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A novel method for efficient generation of transfected human osteoclasts

Calcified tissue international, 2007-02, Vol.80 (2), p.132-136

2007

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Vesicular trafficking in osteoclasts

Seminars in cell & developmental biology, 2008-10, Vol.19 (5), p.424-433

2008

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Human Osteoclast-Poor Osteopetrosis with Hypogammaglobulinemia due to TNFRSF11A ( RANK) Mutations

American journal of human genetics, 2008-07, Vol.83 (1), p.64-76

2008

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Biochemical and molecular mechanisms of action of bisphosphonates

Bone (New York, N.Y.), 2011-07, Vol.49 (1), p.34-41

2011

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SNX10 gene mutation leading to osteopetrosis with dysfunctional osteoclasts

Scientific reports, 2017-06, Vol.7 (1), p.3012-16, Article 3012

2017

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Influence of bone affinity on the skeletal distribution of fluorescently labeled bisphosphonates in vivo

Journal of bone and mineral research, 2012-04, Vol.27 (4), p.835-847

2012

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Protein Synthesis Is Required for Caspase Activation and Induction of Apoptosis by Bisphosphonate Drugs

Molecular pharmacology, 1998-10, Vol.54 (4), p.631-638

1998

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Bisphosphonates: an update on mechanisms of action and how these relate to clinical efficacy

Annals of the New York Academy of Sciences, 2007-11, Vol.1117 (1), p.209-257

2007

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Cytosolic Entry of Bisphosphonate Drugs Requires Acidification of Vesicles after Fluid-Phase Endocytosis

Molecular pharmacology, 2006-05, Vol.69 (5), p.1624-1632

2006

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A new familial sclerosing bone dysplasia

Journal of bone and mineral research, 2010-03, Vol.25 (3), p.676-680

2010

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Bisphosphonates: molecular mechanisms of action and effects on bone cells, monocytes and macrophages

Cellular and molecular mechanisms of action of bisphosphonates

Nitrogen‐Containing Bisphosphonates Inhibit the Mevalonate Pathway and Prevent Post‐Translational Prenylation of GTP‐Binding Proteins, Including Ras

Protein Geranylgeranylation Is Required for Osteoclast Formation, Function, and Survival: Inhibition by Bisphosphonates and GGTI‐298

The pharmacology of bisphosphonates and new insights into their mechanisms of action

Molecular mechanisms of action of bisphosphonates

Heterocycle‐Containing Bisphosphonates Cause Apoptosis and Inhibit Bone Resorption by Preventing Protein Prenylation: Evidence from Structure‐Activity Relationships in J774 Macrophages

The role of prenylated small GTP-binding proteins in the regulation of osteoclast function

Bisphosphonates induce apoptosis in mouse macrophage‐like cells in vitro by a nitric oxide‐independent mechanism

Inhibition of Protein Prenylation by Bisphosphonates Causes Sustained Activation of Rac, Cdc42, and Rho GTPases

Structure-activity relationships for inhibition of farnesyl diphosphate synthase in vitro and inhibition of bone resorption in vivo by nitrogen-containing bisphosphonates

Phosphonocarboxylate inhibitors of Rab geranylgeranyl transferase disrupt the prenylation and membrane localization of Rab proteins in osteoclasts in vitro and in vivo

The citrus flavanone hesperetin decreases osteoclast formation and function in vitro

Identification of a Novel Phosphonocarboxylate Inhibitor of Rab Geranylgeranyl Transferase That Specifically Prevents Rab Prenylation in Osteoclasts and Macrophages

Visualizing mineral binding and uptake of bisphosphonate by osteoclasts and non-resorbing cells

A novel method for efficient generation of transfected human osteoclasts

Vesicular trafficking in osteoclasts

Human Osteoclast-Poor Osteopetrosis with Hypogammaglobulinemia due to TNFRSF11A ( RANK) Mutations

Biochemical and molecular mechanisms of action of bisphosphonates

SNX10 gene mutation leading to osteopetrosis with dysfunctional osteoclasts

Influence of bone affinity on the skeletal distribution of fluorescently labeled bisphosphonates in vivo

Protein Synthesis Is Required for Caspase Activation and Induction of Apoptosis by Bisphosphonate Drugs

Bisphosphonates: an update on mechanisms of action and how these relate to clinical efficacy

Cytosolic Entry of Bisphosphonate Drugs Requires Acidification of Vesicles after Fluid-Phase Endocytosis

A new familial sclerosing bone dysplasia

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