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Network analyses reveal pervasive functional regulation between proteases in the human protease web

PLoS biology, 2014-05, Vol.12 (5), p.e1001869-e1001869

2014

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Defining cellular complexity in human autosomal dominant polycystic kidney disease by multimodal single cell analysis

Nature communications, 2022-10, Vol.13 (1), p.6497-19, Article 6497

2022

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Macrophage-specific metalloelastase (MMP-12) truncates and inactivates ELR+ CXC chemokines and generates CCL2, -7, -8, and -13 antagonists: potential role of the macrophage in terminating polymorphonuclear leukocyte influx

Blood, 2008-10, Vol.112 (8), p.3455-3464

2008

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LPS responsiveness and neutrophil chemotaxis in vivo require PMN MMP-8 activity

PloS one, 2007-03, Vol.2 (3), p.e312-e312

2007

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Antibody-mediated targeting of the Orai1 calcium channel inhibits T cell function

PloS one, 2013-12, Vol.8 (12), p.e82944-e82944

2013

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Matrix Metalloproteinase Processing of CXCL11/I-TAC Results in Loss of Chemoattractant Activity and Altered Glycosaminoglycan Binding

The Journal of biological chemistry, 2008-07, Vol.283 (28), p.19389-19399

2008

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Matrix metalloproteinase 8 deficiency in mice exacerbates inflammatory arthritis through delayed neutrophil apoptosis and reduced caspase 11 expression

Arthritis & rheumatology (Hoboken, N.J.), 2010-12, Vol.62 (12), p.3645-3655

2010

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Proteolytic Processing of SDF-1α Reveals a Change in Receptor Specificity Mediating HIV-Associated Neurodegeneration

Proceedings of the National Academy of Sciences - PNAS, 2006-12, Vol.103 (50), p.19182-19187

2006

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IL-27 promotes T cell-dependent colitis through multiple mechanisms

The Journal of experimental medicine, 2011-01, Vol.208 (1), p.115-123

2011

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Active site specificity profiling datasets of matrix metalloproteinases (MMPs) 1, 2, 3, 7, 8, 9, 12, 13 and 14

Data in brief, 2016-06, Vol.7, p.299-310

2016

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IL-27 supports germinal center function by enhancing IL-21 production and the function of T follicular helper cells

The Journal of experimental medicine, 2010-12, Vol.207 (13), p.2895-2906

2010

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Novel pyridone EP4 agonists featuring allylic alcohol ω-chains

Bioorganic & medicinal chemistry letters, 2020-05, Vol.30 (10), p.127104-127104, Article 127104

2020

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Dual Glycolate Oxidase/Lactate Dehydrogenase A Inhibitors for Primary Hyperoxaluria

ACS medicinal chemistry letters, 2021-07, Vol.12 (7), p.1116-1123

2021

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Tu1672 IL-21 Production and Function in Peripheral Immune Cells From Crohn's Disease Patients

Gastroenterology (New York, N.Y. 1943), 2013-05, Vol.144 (5), p.S-819-S-819

2013

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CTLs Target Th Cells That Acquire Bystander MHC Class I-Peptide Complex from APCs

Journal of Immunology, 2007-07, Vol.179 (2), p.830-836

2007

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PS1-20 IL-27 promotes T-cell dependent colitis through restriction of regulatory T-cell differentiation

Cytokine (Philadelphia, Pa.), 2010-10, Vol.52 (1-2), p.21-21

2010

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Identification of Surrogate Biomarkers Reflecting Tubular Failed Repair in CKD: FR-PO1063

Journal of the American Society of Nephrology, 2023-11, Vol.34 (11S), p.699-699

2023

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Identification of Noninvasive Biomarkers Reflecting Cellular Mechanisms of Endothelin A (ETA) Receptor Activity and Atrasentan Response in CKD: TH-OR16

Journal of the American Society of Nephrology, 2023-11, Vol.34 (11S), p.4-5

2023

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Unsupervised Characterization of the NURTuRE Cohort Reveals Gene Expression and Tissue Remodeling Dynamics Along a Synthetic CKD Progression Axis: SA-PO1011

Journal of the American Society of Nephrology, 2022-11, Vol.33 (11S), p.883-883

2022

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A Novel Approach to Antigen-Specific Deletion of CTL with Minimal Cellular Activation Using α3 Domain Mutants of MHC Class I/Peptide Complex

Immunity (Cambridge, Mass.), 2001, Vol.14 (5), p.591-602

2001

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Precision Medicine Approach Identifies Patients with IgA Nephropathy at Risk for Progression Using Endothelin Activation Signatures: PO1593

Journal of the American Society of Nephrology, 2021-10, Vol.32 (10S), p.499-499

2021

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Single Nuclei RNA-Seq Reveals Cell-Type Specific Responses to Disease and Enalapril in the gddY Mouse Model of IgA Nephropathy: TH-PO419

Journal of the American Society of Nephrology, 2022-11, Vol.33 (11S), p.163-163

2022

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Preclinical Efficacy of CHK-336: A First in Class, Liver-Targeted, Small Molecule Inhibitor of Lactate Dehydrogenase for the Treatment of Primary Hyperoxalurias: FR-PO334

Journal of the American Society of Nephrology, 2022-11, Vol.33 (11S), p.415-415

2022

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A Multi-Omics Approach to IgA Nephropathy Characterization in the NURTuRE Cohort Enables Precision-Based Treatment Approaches: FR-OR60

Journal of the American Society of Nephrology, 2022-11, Vol.33 (11S), p.34-34

2022

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Network analyses reveal pervasive functional regulation between proteases in the human protease web

Defining cellular complexity in human autosomal dominant polycystic kidney disease by multimodal single cell analysis

Macrophage-specific metalloelastase (MMP-12) truncates and inactivates ELR+ CXC chemokines and generates CCL2, -7, -8, and -13 antagonists: potential role of the macrophage in terminating polymorphonuclear leukocyte influx

LPS responsiveness and neutrophil chemotaxis in vivo require PMN MMP-8 activity

Antibody-mediated targeting of the Orai1 calcium channel inhibits T cell function

Matrix Metalloproteinase Processing of CXCL11/I-TAC Results in Loss of Chemoattractant Activity and Altered Glycosaminoglycan Binding

Matrix metalloproteinase 8 deficiency in mice exacerbates inflammatory arthritis through delayed neutrophil apoptosis and reduced caspase 11 expression

Proteolytic Processing of SDF-1α Reveals a Change in Receptor Specificity Mediating HIV-Associated Neurodegeneration

IL-27 promotes T cell-dependent colitis through multiple mechanisms

Active site specificity profiling of the matrix metalloproteinase family: Proteomic identification of 4300 cleavage sites by nine MMPs explored with structural and synthetic peptide cleavage analyses

Active site specificity profiling datasets of matrix metalloproteinases (MMPs) 1, 2, 3, 7, 8, 9, 12, 13 and 14

IL-27 supports germinal center function by enhancing IL-21 production and the function of T follicular helper cells

Novel pyridone EP4 agonists featuring allylic alcohol ω-chains

Dual Glycolate Oxidase/Lactate Dehydrogenase A Inhibitors for Primary Hyperoxaluria

Tu1672 IL-21 Production and Function in Peripheral Immune Cells From Crohn's Disease Patients

CTLs Target Th Cells That Acquire Bystander MHC Class I-Peptide Complex from APCs

PS1-20 IL-27 promotes T-cell dependent colitis through restriction of regulatory T-cell differentiation

Identification of Surrogate Biomarkers Reflecting Tubular Failed Repair in CKD: FR-PO1063

Identification of Noninvasive Biomarkers Reflecting Cellular Mechanisms of Endothelin A (ETA) Receptor Activity and Atrasentan Response in CKD: TH-OR16

Unsupervised Characterization of the NURTuRE Cohort Reveals Gene Expression and Tissue Remodeling Dynamics Along a Synthetic CKD Progression Axis: SA-PO1011

A Novel Approach to Antigen-Specific Deletion of CTL with Minimal Cellular Activation Using α3 Domain Mutants of MHC Class I/Peptide Complex

Precision Medicine Approach Identifies Patients with IgA Nephropathy at Risk for Progression Using Endothelin Activation Signatures: PO1593

Single Nuclei RNA-Seq Reveals Cell-Type Specific Responses to Disease and Enalapril in the gddY Mouse Model of IgA Nephropathy: TH-PO419

Preclinical Efficacy of CHK-336: A First in Class, Liver-Targeted, Small Molecule Inhibitor of Lactate Dehydrogenase for the Treatment of Primary Hyperoxalurias: FR-PO334

A Multi-Omics Approach to IgA Nephropathy Characterization in the NURTuRE Cohort Enables Precision-Based Treatment Approaches: FR-OR60

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