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Polypharmacy to Mitigate Acute and Delayed Radiation Syndromes

Frontiers in pharmacology, 2021-05, Vol.12, p.634477-634477

2021

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Hematopoietic properties of granulocyte colony-stimulating factor/immunoglobulin (G-CSF/IgG-Fc) fusion proteins in normal and neutropenic rodents

PloS one, 2014-03, Vol.9 (3), p.e91990-e91990

2014

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Corrigendum: Polypharmacy to Mitigate Acute and Delayed Radiation Syndromes

Frontiers in pharmacology, 2021-08, Vol.12, p.741485-741485

2021

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Mitochondrial Degeneration and Autophagy Associated With Delayed Effects of Radiation in the Mouse Brain

Frontiers in aging neuroscience, 2019-12, Vol.11, p.357-357

2019

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IFN-γ-tethered hydrogels enhance mesenchymal stem cell-based immunomodulation and promote tissue repair

Biomaterials, 2019-11, Vol.220, p.119403-119403, Article 119403

2019

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PEGylation improves the pharmacokinetic properties and ability of interferon gamma to inhibit growth of a human tumor xenograft in athymic mice

Journal of interferon & cytokine research, 2014-10, Vol.34 (10), p.759-768

2014

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Age and Sex Divergence in Hematopoietic Radiosensitivity in Aged Mouse Models of the Hematopoietic Acute Radiation Syndrome

Radiation research, 2022-09, Vol.198 (3), p.221

2022

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Effect of Age at Time of Irradiation, Sex, Genetic Diversity, and Granulopoietic Cytokine Radiomitigation on Lifespan and Lymphoma Development in Murine H-ARS Survivors

Radiation research, 2024-08, Vol.202 (3)

2024

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Pharmacokinetic and Metabolomic Studies with a Promising Radiation Countermeasure, BBT-059 (PEGylated interleukin-11), in Rhesus Nonhuman Primates

Radiation research, 2024-07, Vol.202 (1), p.26

2024

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Delayed effects of acute whole body lethal radiation exposure in mice pre-treated with BBT-059

Scientific reports, 2020-04, Vol.10 (1), p.6825, Article 6825

2020

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PEGylated IL-11 (BBT-059): A Novel Radiation Countermeasure for Hematopoietic Acute Radiation Syndrome

Health physics (1958), 2018-07, Vol.115 (1), p.65-76

2018

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Interleukin-11 protects against renal ischemia and reperfusion injury

American journal of physiology. Renal physiology, 2012-10, Vol.303 (8), p.F1216-F1224

2012

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Cytokine refacing effect reduces granulocyte macrophage colony-stimulating factor susceptibility to antibody neutralization

Protein engineering, design and selection, 2015-10, Vol.28 (10), p.461-466

2015

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Characterization of a Long-Acting Site-Specific PEGylated Murine GM-CSF Analog and Analysis of Its Hematopoietic Properties in Normal and Cyclophosphamide-Treated Neutropenic Rats

The Protein Journal, 2020-04, Vol.39 (2), p.160-173

2020

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PEGylated G-CSF (BBT-015), GM-CSF (BBT-007), and IL-11 (BBT-059) analogs enhance survival and hematopoietic cell recovery in a mouse model of the hematopoietic syndrome of the acute radiation syndrome

Health physics (1958), 2014-01, Vol.106 (1), p.7-20

2014

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Enhanced circulating half-life and hematopoietic properties of a human granulocyte colony-stimulating factor/immunoglobulin fusion protein

Experimental hematology, 2004-05, Vol.32 (5), p.441-449

2004

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A Long-Acting, Highly Potent Interferon α-2 Conjugate Created Using Site-Specific PEGylation

Bioconjugate chemistry, 2005-01, Vol.16 (1), p.200-207

2005

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Enhanced Circulating Half-Life and Antitumor Activity of a Site-Specific Pegylated Interferon-α Protein Therapeutic

Bioconjugate chemistry, 2008-01, Vol.19 (1), p.299-305

2008

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A Long-Acting, Mono-PEGylated Human Growth Hormone Analog Is a Potent Stimulator of Weight Gain and Bone Growth in Hypophysectomized Rats

Endocrinology (Philadelphia), 2007-04, Vol.148 (4), p.1590-1597

2007

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Site-Specific PEGylation of Engineered Cysteine Analogues of Recombinant Human Granulocyte-Macrophage Colony-Stimulating Factor

Bioconjugate chemistry, 2005-09, Vol.16 (5), p.1291-1298

2005

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Site-specific PEGylation enhances the pharmacokinetic properties and antitumor activity of interferon beta-1b

Journal of interferon & cytokine research, 2013-12, Vol.33 (12), p.769-777

2013

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Cloning and Characterization of a Human Type II Receptor for Bone Morphogenetic Proteins

Proceedings of the National Academy of Sciences - PNAS, 1995-08, Vol.92 (17), p.7632-7636

1995

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Design of homogeneous, monopegylated erythropoietin analogs with preserved in vitro bioactivity

Experimental hematology, 2006-06, Vol.34 (6), p.697-704

2006

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Reversal of MHC-II Downregulation with Interferon Gamma Enhances the Graft-Versus-Leukemia Effect

Transplantation and cellular therapy, 2022-03, Vol.28 (3), p.S430-S431

2022

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554 - Reversal of MHC-II Downregulation with Interferon Gamma Enhances the Graft-Versus-Leukemia Effect

Transplantation and cellular therapy, 2022-03, Vol.28 (3), p.S430-S431

2022

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Polypharmacy to Mitigate Acute and Delayed Radiation Syndromes

Hematopoietic properties of granulocyte colony-stimulating factor/immunoglobulin (G-CSF/IgG-Fc) fusion proteins in normal and neutropenic rodents

Corrigendum: Polypharmacy to Mitigate Acute and Delayed Radiation Syndromes

Mitochondrial Degeneration and Autophagy Associated With Delayed Effects of Radiation in the Mouse Brain

IFN-γ-tethered hydrogels enhance mesenchymal stem cell-based immunomodulation and promote tissue repair

PEGylation improves the pharmacokinetic properties and ability of interferon gamma to inhibit growth of a human tumor xenograft in athymic mice

Age and Sex Divergence in Hematopoietic Radiosensitivity in Aged Mouse Models of the Hematopoietic Acute Radiation Syndrome

Effect of Age at Time of Irradiation, Sex, Genetic Diversity, and Granulopoietic Cytokine Radiomitigation on Lifespan and Lymphoma Development in Murine H-ARS Survivors

Pharmacokinetic and Metabolomic Studies with a Promising Radiation Countermeasure, BBT-059 (PEGylated interleukin-11), in Rhesus Nonhuman Primates

Delayed effects of acute whole body lethal radiation exposure in mice pre-treated with BBT-059

PEGylated IL-11 (BBT-059): A Novel Radiation Countermeasure for Hematopoietic Acute Radiation Syndrome

Interleukin-11 protects against renal ischemia and reperfusion injury

Cytokine refacing effect reduces granulocyte macrophage colony-stimulating factor susceptibility to antibody neutralization

Characterization of a Long-Acting Site-Specific PEGylated Murine GM-CSF Analog and Analysis of Its Hematopoietic Properties in Normal and Cyclophosphamide-Treated Neutropenic Rats

PEGylated G-CSF (BBT-015), GM-CSF (BBT-007), and IL-11 (BBT-059) analogs enhance survival and hematopoietic cell recovery in a mouse model of the hematopoietic syndrome of the acute radiation syndrome

Enhanced circulating half-life and hematopoietic properties of a human granulocyte colony-stimulating factor/immunoglobulin fusion protein

A Long-Acting, Highly Potent Interferon α-2 Conjugate Created Using Site-Specific PEGylation

Enhanced Circulating Half-Life and Antitumor Activity of a Site-Specific Pegylated Interferon-α Protein Therapeutic

A Long-Acting, Mono-PEGylated Human Growth Hormone Analog Is a Potent Stimulator of Weight Gain and Bone Growth in Hypophysectomized Rats

Site-Specific PEGylation of Engineered Cysteine Analogues of Recombinant Human Granulocyte-Macrophage Colony-Stimulating Factor

Site-specific PEGylation enhances the pharmacokinetic properties and antitumor activity of interferon beta-1b

Cloning and Characterization of a Human Type II Receptor for Bone Morphogenetic Proteins

Design of homogeneous, monopegylated erythropoietin analogs with preserved in vitro bioactivity

Reversal of MHC-II Downregulation with Interferon Gamma Enhances the Graft-Versus-Leukemia Effect

554 - Reversal of MHC-II Downregulation with Interferon Gamma Enhances the Graft-Versus-Leukemia Effect

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