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A neurosteroid analogue with T-type calcium channel blocking properties is an effective hypnotic, but is not harmful to neonatal rat brain

British journal of anaesthesia : BJA, 2018-04, Vol.120 (4), p.768-778

2018

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Structural requirements of steroidal agonists of transient receptor potential melastatin 3 (TRPM3) cation channels

British journal of pharmacology, 2014-02, Vol.171 (4), p.1019-1032

2014

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Cyclodextrins sequester neuroactive steroids and differentiate mechanisms that rate limit steroid actions

British journal of pharmacology, 2007-01, Vol.150 (2), p.164-175

2007

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The enantiomer of cholesterol

The Journal of membrane biology, 2004-11, Vol.202 (2), p.61-72

2004

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Epipregnanolone and a novel synthetic neuroactive steroid reduce alcohol self-administration in rats

Pharmacology, biochemistry and behavior, 2005-07, Vol.81 (3), p.543-550

2005

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Inhibition of type a GABA receptors by L-type calcium channel blockers

Neuroscience, 2004, Vol.124 (1), p.195-206

2004

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Multiple mechanisms of picrotoxin block of GABA-induced currents in rat hippocampal neurons

The Journal of physiology, 1993-05, Vol.464 (1), p.423-439

1993

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5α-reduced neuroactive steroids alleviate thermal and mechanical hyperalgesia in rats with neuropathic pain

Pain (Amsterdam), 2005-10, Vol.117 (3), p.326-339

2005

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Pentylenetetrazole-induced inhibition of recombinant gamma-aminobutyric acid type A (GABA(A)) receptors: mechanism and site of action

The Journal of pharmacology and experimental therapeutics, 2001-09, Vol.298 (3), p.986

2001

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Neurosteroid Analogues. 8. Structure−Activity Studies of N-Acylated 17a-Aza-D-homosteroid Analogues of the Anesthetic Steroids (3α,5α)- and (3α,5β)-3-Hydroxypregnan-20-one

Journal of medicinal chemistry, 2000-08, Vol.43 (17), p.3201-3204

2000

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Steroid structure and pharmacological properties determine the anti-amnesic effects of pregnenolone sulphate in the passive avoidance task in rats

The European journal of neuroscience, 2001-12, Vol.14 (12), p.2003-2010

2001

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The Synthetic Enantiomer of Pregnenolone Sulfate is very Active on Memory in Rats and Mice, Even More so Than Its Physiological Neurosteroid Counterpart: Distinct Mechanisms?

Proceedings of the National Academy of Sciences - PNAS, 2001-11, Vol.98 (24), p.14033-14037

2001

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Neuroprotective effects of an estratriene analog are estrogen receptor independent in vitro and in vivo

Brain research, 2005-03, Vol.1038 (2), p.216-222

2005

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The nonfeminizing enantiomer of 17beta-estradiol exerts protective effects in neuronal cultures and a rat model of cerebral ischemia

Endocrinology (Philadelphia), 2001-01, Vol.142 (1), p.400

2001

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Interaction of picrotoxin with GABAA receptor channel-lining residues probed in cysteine mutants

Biophysical journal, 1995-11, Vol.69 (5), p.1858-1867

1995

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Effects of Cholesterol and Enantiomeric Cholesterol on P-Glycoprotein Localization and Function in Low-Density Membrane Domains

Biochemistry (Easton), 2000-07, Vol.39 (26), p.7651-7661

2000

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Photoaffinity labeling with a neuroactive steroid analogue. 6-azi-pregnanolone labels voltage-dependent anion channel-1 in rat brain

The Journal of biological chemistry, 2003-04, Vol.278 (15), p.13196-13206

2003

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Pregnenolone sulfate modulates inhibitory synaptic transmission by enhancing GABA(A) receptor desensitization

The Journal of neuroscience, 2000-05, Vol.20 (10), p.3571-3579

2000

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Multidrug Resistance (MDR1) P-glycoprotein Enhances Esterification of Plasma Membrane Cholesterol

The Journal of biological chemistry, 1999-03, Vol.274 (11), p.6979-6991

1999

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Synthesis and Anticonvulsant Activities of 3,3-Dialkyl- and 3-Alkyl-3-benzyl-2-piperidinones (δ-Valerolactams) and Hexahydro-2H-azepin-2-ones (ε-Caprolactams)

Journal of medicinal chemistry, 1997-01, Vol.40 (1), p.44-49

1997

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Neuroprotective agent riluzole potentiates postsynaptic GABA A receptor function

Neuropharmacology, 2002-02, Vol.42 (2), p.199-209

2002

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Recent developments in structure–activity relationships for steroid modulators of GABA A receptors

Brain Research Reviews, 2001-11, Vol.37 (1), p.91-97

2001

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Effects of anticonvulsant lactams on in vitro seizures in the hippocampal slice preparation

Epilepsy research, 1999-11, Vol.37 (2), p.121-131

1999

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Enantioselectivity of pregnanolone-induced gamma-aminobutyric acid(A) receptor modulation and anesthesia

The Journal of pharmacology and experimental therapeutics, 2000-06, Vol.293 (3), p.1009

2000

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Effects of a benz[e]indene on gamma-aminobutyric acid-gated chloride currents in cultured postnatal rat hippocampal neurons

Molecular pharmacology, 1992-12, Vol.42 (6), p.952-957

1992

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A neurosteroid analogue with T-type calcium channel blocking properties is an effective hypnotic, but is not harmful to neonatal rat brain

Structural requirements of steroidal agonists of transient receptor potential melastatin 3 (TRPM3) cation channels

Cyclodextrins sequester neuroactive steroids and differentiate mechanisms that rate limit steroid actions

The enantiomer of cholesterol

Epipregnanolone and a novel synthetic neuroactive steroid reduce alcohol self-administration in rats

Inhibition of type a GABA receptors by L-type calcium channel blockers

Multiple mechanisms of picrotoxin block of GABA-induced currents in rat hippocampal neurons

5α-reduced neuroactive steroids alleviate thermal and mechanical hyperalgesia in rats with neuropathic pain

Pentylenetetrazole-induced inhibition of recombinant gamma-aminobutyric acid type A (GABA(A)) receptors: mechanism and site of action

Neurosteroid Analogues. 8. Structure−Activity Studies of N-Acylated 17a-Aza-D-homosteroid Analogues of the Anesthetic Steroids (3α,5α)- and (3α,5β)-3-Hydroxypregnan-20-one

Steroid structure and pharmacological properties determine the anti-amnesic effects of pregnenolone sulphate in the passive avoidance task in rats

The Synthetic Enantiomer of Pregnenolone Sulfate is very Active on Memory in Rats and Mice, Even More so Than Its Physiological Neurosteroid Counterpart: Distinct Mechanisms?

Neuroprotective effects of an estratriene analog are estrogen receptor independent in vitro and in vivo

The nonfeminizing enantiomer of 17beta-estradiol exerts protective effects in neuronal cultures and a rat model of cerebral ischemia

Interaction of picrotoxin with GABAA receptor channel-lining residues probed in cysteine mutants

Effects of Cholesterol and Enantiomeric Cholesterol on P-Glycoprotein Localization and Function in Low-Density Membrane Domains

Photoaffinity labeling with a neuroactive steroid analogue. 6-azi-pregnanolone labels voltage-dependent anion channel-1 in rat brain

Pregnenolone sulfate modulates inhibitory synaptic transmission by enhancing GABA(A) receptor desensitization

Multidrug Resistance (MDR1) P-glycoprotein Enhances Esterification of Plasma Membrane Cholesterol

Synthesis and Anticonvulsant Activities of 3,3-Dialkyl- and 3-Alkyl-3-benzyl-2-piperidinones (δ-Valerolactams) and Hexahydro-2H-azepin-2-ones (ε-Caprolactams)

Neuroprotective agent riluzole potentiates postsynaptic GABA A receptor function

Recent developments in structure–activity relationships for steroid modulators of GABA A receptors

Effects of anticonvulsant lactams on in vitro seizures in the hippocampal slice preparation

Enantioselectivity of pregnanolone-induced gamma-aminobutyric acid(A) receptor modulation and anesthesia

Effects of a benz[e]indene on gamma-aminobutyric acid-gated chloride currents in cultured postnatal rat hippocampal neurons

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