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Isoform‐Selective Probe Substrates for In Vitro Studies of Human UDP‐Glucuronosyltransferases

Methods in Enzymology, 2005, Vol.400, p.104-116

Court, Michael H.

2005

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Interindividual variability in acetaminophen glucuronidation by human liver microsomes: identification of relevant acetaminophen UDP-glucuronosyltransferase isoforms

The Journal of pharmacology and experimental therapeutics, 2001-12, Vol.299 (3), p.998

2001

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Interindividual variability in hepatic drug glucuronidation: studies into the role of age, sex, enzyme inducers, and genetic polymorphism using the human liver bank as a model system

Drug metabolism reviews, 2010-02, Vol.42 (1), p.209-224

Court, Michael H.

2010

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Feline Drug Metabolism and Disposition: Pharmacokinetic Evidence for Species Differences and Molecular Mechanisms

The Veterinary clinics of North America. Small animal practice, 2013-09, Vol.43 (5), p.1039-1054

Court, Michael H

2013

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Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for UGT1A1 and Atazanavir Prescribing

Clinical pharmacology and therapeutics, 2016-04, Vol.99 (4), p.363-369

2016

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Tramadol Metabolism to O -Desmethyl Tramadol (M1) and N -Desmethyl Tramadol (M2) by Dog Liver Microsomes: Species Comparison and Identification of Responsible Canine Cytochrome P450s

Drug metabolism and disposition, 2016-12, Vol.44 (12), p.1963-1972

2016

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Oral Coadministration of Fluconazole with Tramadol Markedly Increases Plasma and Urine Concentrations of Tramadol and the O- Desmethyltramadol Metabolite in Healthy Dogs

Drug metabolism and disposition, 2019-01, Vol.47 (1), p.15-25

2019

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Comparative metabolism of mycophenolic acid by glucuronic acid and glucose conjugation in human, dog, and cat liver microsomes

Journal of veterinary pharmacology and therapeutics, 2017-04, Vol.40 (2), p.123-129

2017

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Favipiravir inhibits acetaminophen sulfate formation but minimally affects systemic pharmacokinetics of acetaminophen

British journal of clinical pharmacology, 2015-11, Vol.80 (5), p.1076-1085

2015

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Identification of canine cytochrome P‐450s (CYPs) metabolizing the tramadol (+)‐M1 and (+)‐M2 metabolites to the tramadol (+)‐M5 metabolite in dog liver microsomes

Journal of veterinary pharmacology and therapeutics, 2018-12, Vol.41 (6), p.815-824

2018

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Evaluation of 3'-azido-3'-deoxythymidine, morphine, and codeine as probe substrates for UDP-glucuronosyltransferase 2B7 (UGT2B7) in human liver microsomes: specificity and influence of the UGT2B72 polymorphism

Drug metabolism and disposition, 2003-09, Vol.31 (9), p.1125

2003

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Genotype-phenotype Associations of Cytochrome P450 3A4 and 3A5 Polymorphism with Midazolam Clearance in Vivo

Clinical pharmacology and therapeutics, 2005-05, Vol.77 (5), p.373-387

2005

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CYP2B6 mediates the in vitro hydroxylation of bupropion: potential drug interactions with other antidepressants

Drug metabolism and disposition, 2000-10, Vol.28 (10), p.1176

2000

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UDP glucuronosyltransferase (UGT) 1A6 pharmacogenetics: II. Functional impact of the three most common nonsynonymous UGT1A6 polymorphisms (S7A, T181A, and R184S)

The Journal of pharmacology and experimental therapeutics, 2005-06, Vol.313 (3), p.1340

2005

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UDP-glucuronosyltransferase (UGT) 2B15 pharmacogenetics: UGT2B15 D85Y genotype and gender are major determinants of oxazepam glucuronidation by human liver

The Journal of pharmacology and experimental therapeutics, 2004-08, Vol.310 (2), p.656

2004

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Stereoselective conjugation of oxazepam by human UDP-glucuronosyltransferases (UGTs): S-oxazepam is glucuronidated by UGT2B15, while R-oxazepam is glucuronidated by UGT2B7 and UGT1A9

Drug metabolism and disposition, 2002-11, Vol.30 (11), p.1257

2002

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Effect of extended exposure to grapefruit juice on cytochrome P450 3A activity in humans: Comparison with ritonavir

Clinical pharmacology and therapeutics, 2006-03, Vol.79 (3), p.243-254

2006

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Comparison between cytochrome P450 (CYP) content and relative activity approaches to scaling from cDNA-expressed CYPs to human liver microsomes: ratios of accessory proteins as sources of discrepancies between the approaches

Drug metabolism and disposition, 2000-12, Vol.28 (12), p.1493

2000

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Validation of serotonin (5-hydroxtryptamine) as an in vitro substrate probe for human UDP-glucuronosyltransferase (UGT) 1A6

Drug metabolism and disposition, 2003-01, Vol.31 (1), p.133

2003

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Molecular basis for deficient acetaminophen glucuronidation in cats

Biochemical pharmacology, 1997-04, Vol.53 (7), p.1041-1047

1997

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Short-Term Clarithromycin Administration Impairs Clearance and Enhances Pharmacodynamic Effects of Trazodone but Not of Zolpidem

Clinical pharmacology and therapeutics, 2009-06, Vol.85 (6), p.644-650

2009

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UGT1A1 polymorphisms are important determinants of dietary carcinogen detoxification in the liver

Hepatology (Baltimore, Md.), 2005-08, Vol.42 (2), p.448-457

2005

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Midazolam and triazolam biotransformation in mouse and human liver microsomes: relative contribution of CYP3A and CYP2C isoforms

The Journal of pharmacology and experimental therapeutics, 2000-02, Vol.292 (2), p.618

2000

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Role of CYP3A and CYP2E1 in alcohol-mediated increases in acetaminophen hepatotoxicity: comparison of wild-type and Cyp2e1(-/-) mice

Drug metabolism and disposition, 2007-07, Vol.35 (7), p.1223

2007

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UDP glucuronosyltransferase (UGT) 1A6 pharmacogenetics: I. Identification of polymorphisms in the 5'-regulatory and exon 1 regions, and association with human liver UGT1A6 gene expression and glucuronidation

The Journal of pharmacology and experimental therapeutics, 2005-06, Vol.313 (3), p.1331

2005

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Isoform‐Selective Probe Substrates for In Vitro Studies of Human UDP‐Glucuronosyltransferases

Interindividual variability in acetaminophen glucuronidation by human liver microsomes: identification of relevant acetaminophen UDP-glucuronosyltransferase isoforms

Interindividual variability in hepatic drug glucuronidation: studies into the role of age, sex, enzyme inducers, and genetic polymorphism using the human liver bank as a model system

Feline Drug Metabolism and Disposition: Pharmacokinetic Evidence for Species Differences and Molecular Mechanisms

Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for UGT1A1 and Atazanavir Prescribing

Tramadol Metabolism to O -Desmethyl Tramadol (M1) and N -Desmethyl Tramadol (M2) by Dog Liver Microsomes: Species Comparison and Identification of Responsible Canine Cytochrome P450s

Oral Coadministration of Fluconazole with Tramadol Markedly Increases Plasma and Urine Concentrations of Tramadol and the O- Desmethyltramadol Metabolite in Healthy Dogs

Comparative metabolism of mycophenolic acid by glucuronic acid and glucose conjugation in human, dog, and cat liver microsomes

Favipiravir inhibits acetaminophen sulfate formation but minimally affects systemic pharmacokinetics of acetaminophen

Identification of canine cytochrome P‐450s (CYPs) metabolizing the tramadol (+)‐M1 and (+)‐M2 metabolites to the tramadol (+)‐M5 metabolite in dog liver microsomes

Evaluation of 3'-azido-3'-deoxythymidine, morphine, and codeine as probe substrates for UDP-glucuronosyltransferase 2B7 (UGT2B7) in human liver microsomes: specificity and influence of the UGT2B72 polymorphism

Genotype-phenotype Associations of Cytochrome P450 3A4 and 3A5 Polymorphism with Midazolam Clearance in Vivo

CYP2B6 mediates the in vitro hydroxylation of bupropion: potential drug interactions with other antidepressants

UDP glucuronosyltransferase (UGT) 1A6 pharmacogenetics: II. Functional impact of the three most common nonsynonymous UGT1A6 polymorphisms (S7A, T181A, and R184S)

UDP-glucuronosyltransferase (UGT) 2B15 pharmacogenetics: UGT2B15 D85Y genotype and gender are major determinants of oxazepam glucuronidation by human liver

Stereoselective conjugation of oxazepam by human UDP-glucuronosyltransferases (UGTs): S-oxazepam is glucuronidated by UGT2B15, while R-oxazepam is glucuronidated by UGT2B7 and UGT1A9

Effect of extended exposure to grapefruit juice on cytochrome P450 3A activity in humans: Comparison with ritonavir

Comparison between cytochrome P450 (CYP) content and relative activity approaches to scaling from cDNA-expressed CYPs to human liver microsomes: ratios of accessory proteins as sources of discrepancies between the approaches

Validation of serotonin (5-hydroxtryptamine) as an in vitro substrate probe for human UDP-glucuronosyltransferase (UGT) 1A6

Molecular basis for deficient acetaminophen glucuronidation in cats

Short-Term Clarithromycin Administration Impairs Clearance and Enhances Pharmacodynamic Effects of Trazodone but Not of Zolpidem

UGT1A1 polymorphisms are important determinants of dietary carcinogen detoxification in the liver

Midazolam and triazolam biotransformation in mouse and human liver microsomes: relative contribution of CYP3A and CYP2C isoforms

Role of CYP3A and CYP2E1 in alcohol-mediated increases in acetaminophen hepatotoxicity: comparison of wild-type and Cyp2e1(-/-) mice

UDP glucuronosyltransferase (UGT) 1A6 pharmacogenetics: I. Identification of polymorphisms in the 5'-regulatory and exon 1 regions, and association with human liver UGT1A6 gene expression and glucuronidation

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