UB Paderborn / Katalog / Suche / in CDI

566 GNS396 and analogues are potent new small molecules to target and kill chemotherapy-resistant subpopulation cells in acute myeloid leukemia

European journal of cancer (1990), 2014-11, Vol.50, p.183-183

2014

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Prediction of molecular crystal structures using a genetic algorithm: Validation by GenMol™ on energetic compounds

Journal of crystal growth, 2009-06, Vol.311 (13), p.3498-3510

2009

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1205 PRELIMINARY EVALUATION OF A NEW AUTOPHAGY INHIBITOR ANTIVIRAL AGENT FOR HEPATITIS C VIRUS IN AN EX VIVO MODEL OF HUMAN LIVER SLICES CULTURE

Journal of hepatology, 2013-04, Vol.58, p.S490-S490

2013

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1168 BL-8030: A NOVEL, POTENT, SELECTIVE, ORALLY AVAILABLE INHIBITOR OF HEPATITIS C VIRUS NS3/4A PROTEASE

Journal of hepatology, 2013-04, Vol.58, p.S475-S475

2013

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Mechanistic Basis for Reduced Viral and Enzymatic Fitness of HIV-1 Reverse Transcriptase Containing Both K65R and M184V Mutations

The Journal of biological chemistry, 2004-01, Vol.279 (1), p.509-516

2004

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Prediction of HIV-1 protease inhibitor resistance by Molecular Modeling Protocols (MMPs) using GenMol™ software

European journal of medicinal chemistry, 2008-11, Vol.43 (11), p.2518-2534

2008

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1210 GNS-227: A NEW POTENT AND SELECTIVE HCV NS3 PROTEASE INHIBITOR WITH A HIGH GENETIC BARRIER TO RESISTANCE

Journal of hepatology, 2011-03, Vol.54, p.S478-S478

2011

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Structural determinants and molecular mechanisms for the resistance of HIV-1 RT to nucleoside analogues

Current drug metabolism, 2004-08, Vol.5 (4), p.305

2004

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A Loss of Viral Replicative Capacity Correlates with Altered DNA Polymerization Kinetics by the Human Immunodeficiency Virus Reverse Transcriptase Bearing the K65R and L74V Dideoxynucleoside Resistance Substitutions

The Journal of biological chemistry, 2004-06, Vol.279 (24), p.25489-25496

2004

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use of proline bioisosteres in potential HIV protease inhibitors: phenylalanine-2-thiophenoxy-3-pyrrolidinone: synthesis and anti-HIV evaluation

Bioorganic & medicinal chemistry letters, 2000-09, Vol.10 (17), p.2023-2026

2000

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Résistance aux analogues de nucléosides dans le traitement de l’hépatite chronique B

La revue de medecine interne, 2003-12, Vol.24 (12), p.786-793

2003

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Design of potential new HIV protease inhibitors: enantioconvergent synthesis of new pyrrolidin-3-ol, and pyrrolidin-3-one peptide conjugates

Perkin 1 : an international journal of organic and bio-organic chemistry, 2001 (12), p.1421-1430

2001

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Prediction of molecular crystal structures using genetic algorithm. Validation by GenMolTM on energitic compounds

Journal of crystal growth, 2009, Vol.311, p.3498-3510

2009

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Synthesis and Antiviral Evaluation of Cis-Substituted Cyclohexenyl and Cyclohexanyl Nucleosides

Journal of medicinal chemistry, 2005-01, Vol.48 (2), p.450-456

2005

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Mutation rate in hepatitis C virus NS3 protease is not influenced by HIV-1 protease inhibitor therapy

AIDS (London), 2008-08, Vol.22 (13), p.1694-1696

2008

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Stereoselective synthesis of (3 S,4 S)- tert-butyl- N-Boc-3-ethyl-4-hydroxy- l-prolinate and (3 S,4 R)- tert-butyl- N-Boc-3-ethyl-4-hydroxy- l-prolinate

Tetrahedron, 2005-04, Vol.61 (15), p.3725-3731

2005

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Prediction of HIV-1 protease inhibitor resistance by molecular modelling protocols (MMP's) using GenMolTM software

European journal of medicinal chemistry, 2008, Vol.43, p.2518-2534

2008

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How hepatitis c virus NS3-4A protease R155K/T strains can discriminate VX-950 and ITMN-191 but affect differentially SCH-503034

Antiviral therapy, 2008, Vol.13 (4), p.A43-A43

2008

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Synthesis and Antiviral Activity of New Anti-HIV Amprenavir Bioisosteres

Journal of medicinal chemistry, 2002-07, Vol.45 (15), p.3321-3324

2002

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Phenacyl (2 S ,4 S )-1- tert -butoxycarbonyl-4-hydroxyprolinate

Acta crystallographica. Section E, Structure reports online, 2005-03, Vol.61 (3), p.o792-o794

2005

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Synthesis and antiviral activity of new anti-HIV amprenavir bioisosteres

Journal of medicinal chemistry, 2002, Vol.45, p.3321-24

2002

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CO14 - Mécanismes moléculaires du profil de sensibilité du BILN-2061 des différents génotypes du virus de L’hépatite C (VHC) et des mutations de résistance de la protéase NS3-NS4A : D168A et D168V

Gastroentérologie clinique et biologique, 2004-08, Vol.28 (8), p.768-768

2004

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Nucleoside analogues resistance in the treatment of chronic hepatitis B virus infection

La revue de medecine interne, 2003-12, Vol.24 (12), p.786-793

2003

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ChemInform Abstract: Use of Proline Bioisosteres in Potential HIV Protease Inhibitors: Phenylalanine-2-thiophenoxy-3-pyrrolidinone: Synthesis and Anti-HIV Evaluation

ChemInform, 2000-11, Vol.31 (48), p.no-no

2000

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ChemInform Abstract: Synthesis and Chemical Reactivity of Thiophenoxyphenylalanine Bioisosteres, Suitable Synthons for the Design of HIV Protease Inhibitors

ChemInform, 2000-07, Vol.31 (28), p.no-no

2000

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566 GNS396 and analogues are potent new small molecules to target and kill chemotherapy-resistant subpopulation cells in acute myeloid leukemia

Prediction of molecular crystal structures using a genetic algorithm: Validation by GenMol™ on energetic compounds

1205 PRELIMINARY EVALUATION OF A NEW AUTOPHAGY INHIBITOR ANTIVIRAL AGENT FOR HEPATITIS C VIRUS IN AN EX VIVO MODEL OF HUMAN LIVER SLICES CULTURE

1168 BL-8030: A NOVEL, POTENT, SELECTIVE, ORALLY AVAILABLE INHIBITOR OF HEPATITIS C VIRUS NS3/4A PROTEASE

Mechanistic Basis for Reduced Viral and Enzymatic Fitness of HIV-1 Reverse Transcriptase Containing Both K65R and M184V Mutations

Prediction of HIV-1 protease inhibitor resistance by Molecular Modeling Protocols (MMPs) using GenMol™ software

1210 GNS-227: A NEW POTENT AND SELECTIVE HCV NS3 PROTEASE INHIBITOR WITH A HIGH GENETIC BARRIER TO RESISTANCE

Structural determinants and molecular mechanisms for the resistance of HIV-1 RT to nucleoside analogues

A Loss of Viral Replicative Capacity Correlates with Altered DNA Polymerization Kinetics by the Human Immunodeficiency Virus Reverse Transcriptase Bearing the K65R and L74V Dideoxynucleoside Resistance Substitutions

use of proline bioisosteres in potential HIV protease inhibitors: phenylalanine-2-thiophenoxy-3-pyrrolidinone: synthesis and anti-HIV evaluation

Résistance aux analogues de nucléosides dans le traitement de l’hépatite chronique B

Design of potential new HIV protease inhibitors: enantioconvergent synthesis of new pyrrolidin-3-ol, and pyrrolidin-3-one peptide conjugates

Prediction of molecular crystal structures using genetic algorithm. Validation by GenMolTM on energitic compounds

Synthesis and Antiviral Evaluation of Cis-Substituted Cyclohexenyl and Cyclohexanyl Nucleosides

Mutation rate in hepatitis C virus NS3 protease is not influenced by HIV-1 protease inhibitor therapy

Stereoselective synthesis of (3 S,4 S)- tert-butyl- N-Boc-3-ethyl-4-hydroxy- l-prolinate and (3 S,4 R)- tert-butyl- N-Boc-3-ethyl-4-hydroxy- l-prolinate

Prediction of HIV-1 protease inhibitor resistance by molecular modelling protocols (MMP's) using GenMolTM software

How hepatitis c virus NS3-4A protease R155K/T strains can discriminate VX-950 and ITMN-191 but affect differentially SCH-503034

Synthesis and Antiviral Activity of New Anti-HIV Amprenavir Bioisosteres

Phenacyl (2 S ,4 S )-1- tert -butoxycarbonyl-4-hydroxyprolinate

Synthesis and antiviral activity of new anti-HIV amprenavir bioisosteres

CO14 - Mécanismes moléculaires du profil de sensibilité du BILN-2061 des différents génotypes du virus de L’hépatite C (VHC) et des mutations de résistance de la protéase NS3-NS4A : D168A et D168V

Nucleoside analogues resistance in the treatment of chronic hepatitis B virus infection

ChemInform Abstract: Use of Proline Bioisosteres in Potential HIV Protease Inhibitors: Phenylalanine-2-thiophenoxy-3-pyrrolidinone: Synthesis and Anti-HIV Evaluation

ChemInform Abstract: Synthesis and Chemical Reactivity of Thiophenoxyphenylalanine Bioisosteres, Suitable Synthons for the Design of HIV Protease Inhibitors

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