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Designing Chimeric Molecules for Drug Discovery by Leveraging Chemical Biology

Journal of medicinal chemistry, 2020-03, Vol.63 (5), p.1908-1928

2020

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Decoding the Structural Basis For Carbapenem Hydrolysis By Class A β-lactamases: Fishing For A Pharmacophore

Current drug targets, 2016-07, Vol.17 (9), p.983

2016

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Sesquiterpene Lactones with Dual Inhibitory Activity against the Trypanosoma brucei Pteridine Reductase 1 and Dihydrofolate Reductase

Molecules (Basel, Switzerland), 2021-12, Vol.27 (1), p.149

2021

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In Silico Identification and In Vitro Evaluation of Natural Inhibitors of Leishmania major Pteridine Reductase I

Molecules (Basel, Switzerland), 2017-12, Vol.22 (12), p.2166

2017

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Antitarget, Anti-SARS-CoV‑2 Leads, Drugs, and the Drug Discovery–Genetics Alliance Perspective

Journal of medicinal chemistry, 2023-03, Vol.66 (6), p.3664-3702

2023

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Proteomic and Bioinformatic Studies for the Characterization of Response to Pemetrexed in Platinum Drug Resistant Ovarian Cancer

Frontiers in pharmacology, 2018-05, Vol.9, p.454-454

2018

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Permeation through the cell membrane of a boron-based β-lactamase inhibitor

PloS one, 2011, Vol.6 (8), p.e23187

2011

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Call for Papers: One Health and Vector-Borne Parasitic Diseases

ACS infectious diseases, 2023-08, Vol.9 (8), p.1449-1450

2023

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Exploiting the 2‑Amino-1,3,4-thiadiazole Scaffold To Inhibit Trypanosoma brucei Pteridine Reductase in Support of Early-Stage Drug Discovery

ACS omega, 2017-09, Vol.2 (9), p.5666-5683

2017

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Folic Acid–Peptide Conjugates Combine Selective Cancer Cell Internalization with Thymidylate Synthase Dimer Interface Targeting

Journal of medicinal chemistry, 2021-03, Vol.64 (6), p.3204-3221

2021

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Multitarget, Selective Compound Design Yields Potent Inhibitors of a Kinetoplastid Pteridine Reductase 1

Journal of medicinal chemistry, 2022-07, Vol.65 (13), p.9011-9033

2022

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Label-free fiber optic optrode for the detection of class C β-lactamases expressed by drug resistant bacteria

Biomedical optics express, 2017-11, Vol.8 (11), p.5191-5205

2017

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Alanine Mutants of the Interface Residues of Human Thymidylate Synthase Decode Key Features of the Binding Mode of Allosteric Anticancer Peptides

Journal of medicinal chemistry, 2015-01, Vol.58 (2), p.1012-1018

2015

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Pharmacokinetics and disposition of miltefosine in healthy mice and hamsters experimentally infected with Leishmania infantum

European journal of pharmaceutical sciences, 2018-08, Vol.121, p.281-286

2018

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Novel Approaches for Targeting Thymidylate Synthase To Overcome the Resistance and Toxicity of Anticancer Drugs

Journal of medicinal chemistry, 2010-09, Vol.53 (18), p.6539-6549

2010

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Characterization of 2,4-Diamino-6-oxo-1,6-dihydropyrimidin-5-yl Ureido Based Inhibitors of Trypanosoma brucei FolD and Testing for Antiparasitic Activity

Journal of medicinal chemistry, 2015-10, Vol.58 (20), p.7938-7948

2015

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Spermidine/spermine N1-acetyltranferase modulation by novel folate cycle inhibitors in cisplatin-sensitive and -resistant human ovarian cancer cell lines

Gynecologic oncology, 2010-05, Vol.117 (2), p.202-210

2010

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Biological evaluation of MR36, a novel non-polyglutamatable thymidylate synthase inhibitor that blocks cell cycle progression in melanoma cell lines

Investigational new drugs, 2012-08, Vol.30 (4), p.1484-1492

2012

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Permeation through the Cell Membrane of a Boron-Based [beta]-Lactamase Inhibitor

PloS one, 2011-08, Vol.6 (8), p.e23187

2011

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Spermidine/spermine N 1-acetyltranferase modulation by novel folate cycle inhibitors in cisplatin-sensitive and -resistant human ovarian cancer cell lines

Gynecologic oncology, 2009, Vol.117 (2), p.202-210

2009

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Virtual screening identifies broad-spectrum β-lactamase inhibitors with activity on clinically relevant serine- and metallo-carbapenemases

Scientific reports, 2020-07, Vol.10 (1), p.12763-12763, Article 12763

2020

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Computational and biological profile of boronic acids for the detection of bacterial serine- and metallo-β-lactamases

Scientific reports, 2017-12, Vol.7 (1), p.17716-15, Article 17716

2017

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Defining Criteria for Disease Activity States in Systemic Juvenile Idiopathic Arthritis Based on the Systemic Juvenile Arthritis Disease Activity Score

Arthritis & rheumatology (Hoboken, N.J.), 2024-09, Vol.76 (9), p.1446-1454

2024

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The impact of chest CT body composition parameters on clinical outcomes in COVID-19 patients

PloS one, 2021-05, Vol.16 (5), p.e0251768-e0251768

2021

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The Systemic Score May Identify Life‐Threatening Evolution in Still Disease: Data from the GIRRCS AOSD‐Study Group and the AIDA Network Still Disease Registry

Arthritis & rheumatology (Hoboken, N.J.), 2024-07, Vol.76 (7), p.1141-1152

2024

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Designing Chimeric Molecules for Drug Discovery by Leveraging Chemical Biology

Decoding the Structural Basis For Carbapenem Hydrolysis By Class A β-lactamases: Fishing For A Pharmacophore

Sesquiterpene Lactones with Dual Inhibitory Activity against the Trypanosoma brucei Pteridine Reductase 1 and Dihydrofolate Reductase

In Silico Identification and In Vitro Evaluation of Natural Inhibitors of Leishmania major Pteridine Reductase I

Antitarget, Anti-SARS-CoV‑2 Leads, Drugs, and the Drug Discovery–Genetics Alliance Perspective

Proteomic and Bioinformatic Studies for the Characterization of Response to Pemetrexed in Platinum Drug Resistant Ovarian Cancer

Permeation through the cell membrane of a boron-based β-lactamase inhibitor

Call for Papers: One Health and Vector-Borne Parasitic Diseases

Exploiting the 2‑Amino-1,3,4-thiadiazole Scaffold To Inhibit Trypanosoma brucei Pteridine Reductase in Support of Early-Stage Drug Discovery

Folic Acid–Peptide Conjugates Combine Selective Cancer Cell Internalization with Thymidylate Synthase Dimer Interface Targeting

Multitarget, Selective Compound Design Yields Potent Inhibitors of a Kinetoplastid Pteridine Reductase 1

Label-free fiber optic optrode for the detection of class C β-lactamases expressed by drug resistant bacteria

Alanine Mutants of the Interface Residues of Human Thymidylate Synthase Decode Key Features of the Binding Mode of Allosteric Anticancer Peptides

Pharmacokinetics and disposition of miltefosine in healthy mice and hamsters experimentally infected with Leishmania infantum

Novel Approaches for Targeting Thymidylate Synthase To Overcome the Resistance and Toxicity of Anticancer Drugs

Characterization of 2,4-Diamino-6-oxo-1,6-dihydropyrimidin-5-yl Ureido Based Inhibitors of Trypanosoma brucei FolD and Testing for Antiparasitic Activity

Spermidine/spermine N1-acetyltranferase modulation by novel folate cycle inhibitors in cisplatin-sensitive and -resistant human ovarian cancer cell lines

Biological evaluation of MR36, a novel non-polyglutamatable thymidylate synthase inhibitor that blocks cell cycle progression in melanoma cell lines

Permeation through the Cell Membrane of a Boron-Based [beta]-Lactamase Inhibitor

Spermidine/spermine N 1-acetyltranferase modulation by novel folate cycle inhibitors in cisplatin-sensitive and -resistant human ovarian cancer cell lines

Virtual screening identifies broad-spectrum β-lactamase inhibitors with activity on clinically relevant serine- and metallo-carbapenemases

Computational and biological profile of boronic acids for the detection of bacterial serine- and metallo-β-lactamases

Defining Criteria for Disease Activity States in Systemic Juvenile Idiopathic Arthritis Based on the Systemic Juvenile Arthritis Disease Activity Score

The impact of chest CT body composition parameters on clinical outcomes in COVID-19 patients

The Systemic Score May Identify Life‐Threatening Evolution in Still Disease: Data from the GIRRCS AOSD‐Study Group and the AIDA Network Still Disease Registry

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