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EGCG binds intrinsically disordered N-terminal domain of p53 and disrupts p53-MDM2 interaction

Nature communications, 2021-02, Vol.12 (1), p.986-11, Article 986

2021

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ALS-Linked Mutations Affect UBQLN2 Oligomerization and Phase Separation in a Position- and Amino Acid-Dependent Manner

Structure (London), 2019-06, Vol.27 (6), p.937-951.e5

2019

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Biochemical Reconstitution and Phylogenetic Comparison of Human SET1 Family Core Complexes Involved in Histone Methylation

The Journal of biological chemistry, 2015-03, Vol.290 (10), p.6361-6375

2015

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Structure of WDR5 Bound to Mixed Lineage Leukemia Protein-1 Peptide

The Journal of biological chemistry, 2008-11, Vol.283 (47), p.32158-32161

2008

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A Conserved Arginine-containing Motif Crucial for the Assembly and Enzymatic Activity of the Mixed Lineage Leukemia Protein-1 Core Complex

The Journal of biological chemistry, 2008-11, Vol.283 (47), p.32162-32175

2008

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On the Mechanism of Multiple Lysine Methylation by the Human Mixed Lineage Leukemia Protein-1 (MLL1) Core Complex

The Journal of biological chemistry, 2009-09, Vol.284 (36), p.24242-24256

2009

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Disentangling the recognition complexity of a protein hub using a nanopore

Nature communications, 2022-02, Vol.13 (1), p.978-978, Article 978

2022

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Parallel functional annotation of cancer-associated missense mutations in histone methyltransferases

Scientific reports, 2022-11, Vol.12 (1), p.18487-18487, Article 18487

2022

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Targeted Disruption of the Interaction between WD-40 Repeat Protein 5 (WDR5) and Mixed Lineage Leukemia (MLL)/SET1 Family Proteins Specifically Inhibits MLL1 and SETd1A Methyltransferase Complexes

The Journal of biological chemistry, 2016-10, Vol.291 (43), p.22357-22372

2016

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Regulated nucleosome mobility and the histone code

Nature structural & molecular biology, 2004-11, Vol.11 (11), p.1037-1043

2004

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Small Molecule-Induced Domain Swapping as a Mechanism for Controlling Protein Function and Assembly

Scientific reports, 2017-03, Vol.7 (1), p.44388-44388, Article 44388

2017

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Insights into the Role of Histone H3 and Histone H4 Core Modifiable Residues in Saccharomyces cerevisiae

Molecular and Cellular Biology, 2005-11, Vol.25 (22), p.10060-10070

2005

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Allosteric Activation of the Phosphoinositide Phosphatase Sac1 by Anionic Phospholipids

Biochemistry (Easton), 2012-04, Vol.51 (15), p.3170-3177

2012

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High affinity binding of H3K14ac through collaboration of bromodomains 2, 4 and 5 is critical for the molecular and tumor suppressor functions of PBRM1

Molecular oncology, 2019-04, Vol.13 (4), p.811-828

2019

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Characterization of the Grp94/OS-9 Chaperone–Lectin Complex

Journal of molecular biology, 2014-10, Vol.426 (21), p.3590-3605

2014

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Structure of a Sir2 Enzyme Bound to an Acetylated p53 Peptide

Molecular cell, 2002-09, Vol.10 (3), p.523-535

2002

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The Structural Basis of Sirtuin Substrate Affinity

Biochemistry (Easton), 2006-06, Vol.45 (24), p.7511-7521

2006

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Structure analysis suggests Ess1 isomerizes the carboxy-terminal domain of RNA polymerase II via a bivalent anchoring mechanism

Communications biology, 2021-03, Vol.4 (1), p.398-398, Article 398

2021

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Hierarchical assembly of the MLL1 core complex regulates H3K4 methylation and is dependent on temperature and component concentration

The Journal of biological chemistry, 2023-02, Vol.299 (2), p.102874-102874, Article 102874

2023

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Mixed lineage leukemia: a structure-function perspective of the MLL1 protein

The FEBS journal, 2010-04, Vol.277 (8), p.1832-1842

2010

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Phase separation promotes a highly active oligomeric scaffold of the MLL1 core complex for regulation of histone H3K4 methylation

The Journal of biological chemistry, 2023-10, Vol.299 (10), p.105204-105204, Article 105204

2023

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The Bin3 RNA methyltransferase targets 7SK RNA to control transcription and translation

Wiley interdisciplinary reviews. RNA, 2012-09, Vol.3 (5), p.633-647

2012

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Interplay of Affinity and Surface Tethering in Protein Recognition

The journal of physical chemistry letters, 2022-05, Vol.13 (18), p.4021-4028

2022

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Probing multiple enzymatic methylation events in real time with NMR spectroscopy

Biophysical journal, 2021-11, Vol.120 (21), p.4710-4721

2021

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Mechanistic insights into enhancement or inhibition of phase separation by different polyubiquitin chains

EMBO reports, 2022-08, Vol.23 (8), p.e55056-n/a

2022

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EGCG binds intrinsically disordered N-terminal domain of p53 and disrupts p53-MDM2 interaction

ALS-Linked Mutations Affect UBQLN2 Oligomerization and Phase Separation in a Position- and Amino Acid-Dependent Manner

Biochemical Reconstitution and Phylogenetic Comparison of Human SET1 Family Core Complexes Involved in Histone Methylation

Structure of WDR5 Bound to Mixed Lineage Leukemia Protein-1 Peptide

A Conserved Arginine-containing Motif Crucial for the Assembly and Enzymatic Activity of the Mixed Lineage Leukemia Protein-1 Core Complex

On the Mechanism of Multiple Lysine Methylation by the Human Mixed Lineage Leukemia Protein-1 (MLL1) Core Complex

Disentangling the recognition complexity of a protein hub using a nanopore

Parallel functional annotation of cancer-associated missense mutations in histone methyltransferases

Targeted Disruption of the Interaction between WD-40 Repeat Protein 5 (WDR5) and Mixed Lineage Leukemia (MLL)/SET1 Family Proteins Specifically Inhibits MLL1 and SETd1A Methyltransferase Complexes

Regulated nucleosome mobility and the histone code

Small Molecule-Induced Domain Swapping as a Mechanism for Controlling Protein Function and Assembly

Insights into the Role of Histone H3 and Histone H4 Core Modifiable Residues in Saccharomyces cerevisiae

Allosteric Activation of the Phosphoinositide Phosphatase Sac1 by Anionic Phospholipids

High affinity binding of H3K14ac through collaboration of bromodomains 2, 4 and 5 is critical for the molecular and tumor suppressor functions of PBRM1

Characterization of the Grp94/OS-9 Chaperone–Lectin Complex

Structure of a Sir2 Enzyme Bound to an Acetylated p53 Peptide

The Structural Basis of Sirtuin Substrate Affinity

Structure analysis suggests Ess1 isomerizes the carboxy-terminal domain of RNA polymerase II via a bivalent anchoring mechanism

Hierarchical assembly of the MLL1 core complex regulates H3K4 methylation and is dependent on temperature and component concentration

Mixed lineage leukemia: a structure-function perspective of the MLL1 protein

Phase separation promotes a highly active oligomeric scaffold of the MLL1 core complex for regulation of histone H3K4 methylation

The Bin3 RNA methyltransferase targets 7SK RNA to control transcription and translation

Interplay of Affinity and Surface Tethering in Protein Recognition

Probing multiple enzymatic methylation events in real time with NMR spectroscopy

Mechanistic insights into enhancement or inhibition of phase separation by different polyubiquitin chains

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