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Synthesis and Biological Activity of 3- and 5-Amino Derivatives of Pyridine-2-carboxaldehyde Thiosemicarbazone

Journal of medicinal chemistry, 1996-06, Vol.39 (13), p.2586-2593

1996

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Apoptosis induced by inhibitors of nucleotide synthesis in deoxyadenosine-resistant leukemia L1210 cells that lack p53 expression

Anticancer research, 2000-11, Vol.20 (6B), p.4171

2000

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Overexpression of the multidrug resistance genes mdr1, mdr3, and mrp in L1210 leukemia cells resistant to inhibitors of ribonucleotide reductase

Biochemical pharmacology, 1997-09, Vol.54 (6), p.649-655

1997

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Increased sensitivity to sodium salicylate-induced apoptosis in drug-resistant leukemia L1210 cells

Anticancer research, 2001-01, Vol.21 (1A), p.173

2001

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Deoxyadenosine-resistant mouse leukemia L1210 cell lines with alterations in early response genes and p53

Anticancer research, 1996-11, Vol.16 (6B), p.3483

1996

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Altered efflux properties of mouse leukemia L1210 cells resistant to 4-methyl-5-amino-1-formylisoquinoline thiosemicarbazone

Anticancer research, 1997-09, Vol.17 (5A), p.3185

1997

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Deoxyguanosine-resistant leukemia L1210 cells. Loss of specific deoxyribonucleoside kinase activity

The Journal of biological chemistry, 1993-01, Vol.268 (1), p.405-409

1993

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2′-deoxy-2′-methylene derivatives of adenosine, guanosine, tubercidin, cytidine and uridine as inhibitors of L1210 cell growth in culture

Biochemical pharmacology, 1994-01, Vol.47 (2), p.365-371

1994

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Use of an aqueous soluble tetrazolium/formazan assay for cell growth assays in culture

Cancer communications (New York), 1991-07, Vol.3 (7), p.207

1991

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Augmentation of apoptosis responses in p53-deficient L1210 cells by compounds directed at blocking NFkappaB activation

Anticancer research, 2001-11, Vol.21 (6A), p.3807

2001

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Altered steady-state levels of the messenger RNAs for c-myc and p53 in L1210 cell lines resistant to deoxyadenosine

Cancer research (Baltimore), 1992-04, Vol.52 (7), p.2000-2003

1992

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Characterization of mouse leukemia L1210 cells resistant to the ribonucleotide reductase inhibitor 4-methyl-5-amino-1-formylisoquinoline thiosemicarbazone

Oncology research, 1996, Vol.8 (10-11), p.449

1996

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Substituted 2-acylpyridine-alpha-(N)-hetarylhydrazones as inhibitors of ribonucleotide reductase activity and L1210 cell growth

Anticancer research, 1994-05, Vol.14 (3A), p.875

1994

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Cellular Responses in Mouse Leukemia L1210 Cells Made Resistant to Deoxyadenosine

Biochemical and biophysical research communications, 1998-08, Vol.249 (3), p.687-691

1998

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Liver microsomal inactivation of 4-methyl-5-amino-1-formylisoquinoline thiosemicarbazone as an inhibitor of ribonucleotide reductase

Cancer research (Chicago, Ill.), 1988-11, Vol.48 (22), p.6375-6378

1988

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Triapine (3-aminopyridine-2-carboxaldehyde thiosemicarbazone; 3-AP): an inhibitor of ribonucleotide reductase with antineoplastic activity

Advances in enzyme regulation, 1999-01, Vol.39 (1), p.3-12

1999

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Inhibitors of ribonucleotide reductase : comparative effects of amino- and hydroxy-substituted pyridine-2-carboxaldehyde thiosemicarbazones

Biochemical pharmacology, 1994-07, Vol.48 (2), p.335-344

1994

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Lipophilic derivatives of cyclam as new inhibitors of tumor cell growth

Chemical communications (Cambridge, England), 2002-01 (2), p.154-155

2002

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Effects of PRIMA-1 on Wild-type L1210 Cells Expressing Mutant p53 and Drug-resistant L1210 Cells Lacking Expression of p53: Necrosis vs. Apoptosis

Anticancer research, 2006-03, Vol.26 (2A), p.1289-1295

2006

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Differential substrate properties of mammalian ribonucleotide reductase

Advances in experimental medicine and biology, 1994, Vol.370, p.631

1994

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Effects of 2',2'-difluorodeoxycytidine (Gemcitabine) on wild type and variant mouse leukemia L1210 cells

Oncology research, 1993, Vol.5 (2), p.59

1993

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Lactacystin, a proteasome inhibitor, potentiates the apoptotic effect of parthenolide, an inhibitor of NFkappaB activation, on drug-resistant mouse leukemia L1210 cells

Anticancer research, 2002-11, Vol.22 (6C), p.3805

2002

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5-(3-carboxymethoxyphenyl)-2-(4,5-dimethylthiazolyl)-3-(4-sulfophenyl)tetrazolium, inner salt (MTS) and related analogs of 3-(4,5-dimethylthiazolyl)-2,5-diphenyltetrazolium bromide (MTT) reducing to purple water-soluble formazans As cell-viability indicators

Bioorganic & medicinal chemistry letters, 1991, Vol.1 (11), p.611-614

1991

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Blockage of Cyclin cdk's, PKC and Phosphoinositol 3-kinase Pathways Leads to Augmentation of Apoptosis in Drug-resistant Leukemia Cells: Evidence for Interactive Effects of Flavopiridol, LY 294002, Roscovitine, Wortmannin and UCN-01

Anticancer research, 2005-01, Vol.25 (1A), p.101-106

2005

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Phenolic Compounds, Sodium Salicylate and Related Compounds, as Inhibitors of Tumor Cell Growth and Inducers of Apoptosis in Mouse Leukemia L1210 Cells

In vivo (Athens), 2005-01, Vol.19 (1), p.31

2005

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Synthesis and Biological Activity of 3- and 5-Amino Derivatives of Pyridine-2-carboxaldehyde Thiosemicarbazone

Apoptosis induced by inhibitors of nucleotide synthesis in deoxyadenosine-resistant leukemia L1210 cells that lack p53 expression

Overexpression of the multidrug resistance genes mdr1, mdr3, and mrp in L1210 leukemia cells resistant to inhibitors of ribonucleotide reductase

Increased sensitivity to sodium salicylate-induced apoptosis in drug-resistant leukemia L1210 cells

Deoxyadenosine-resistant mouse leukemia L1210 cell lines with alterations in early response genes and p53

Altered efflux properties of mouse leukemia L1210 cells resistant to 4-methyl-5-amino-1-formylisoquinoline thiosemicarbazone

Deoxyguanosine-resistant leukemia L1210 cells. Loss of specific deoxyribonucleoside kinase activity

2′-deoxy-2′-methylene derivatives of adenosine, guanosine, tubercidin, cytidine and uridine as inhibitors of L1210 cell growth in culture

Use of an aqueous soluble tetrazolium/formazan assay for cell growth assays in culture

Augmentation of apoptosis responses in p53-deficient L1210 cells by compounds directed at blocking NFkappaB activation

Altered steady-state levels of the messenger RNAs for c-myc and p53 in L1210 cell lines resistant to deoxyadenosine

Characterization of mouse leukemia L1210 cells resistant to the ribonucleotide reductase inhibitor 4-methyl-5-amino-1-formylisoquinoline thiosemicarbazone

Substituted 2-acylpyridine-alpha-(N)-hetarylhydrazones as inhibitors of ribonucleotide reductase activity and L1210 cell growth

Cellular Responses in Mouse Leukemia L1210 Cells Made Resistant to Deoxyadenosine

Liver microsomal inactivation of 4-methyl-5-amino-1-formylisoquinoline thiosemicarbazone as an inhibitor of ribonucleotide reductase

Triapine (3-aminopyridine-2-carboxaldehyde thiosemicarbazone; 3-AP): an inhibitor of ribonucleotide reductase with antineoplastic activity

Inhibitors of ribonucleotide reductase : comparative effects of amino- and hydroxy-substituted pyridine-2-carboxaldehyde thiosemicarbazones

Lipophilic derivatives of cyclam as new inhibitors of tumor cell growth

Effects of PRIMA-1 on Wild-type L1210 Cells Expressing Mutant p53 and Drug-resistant L1210 Cells Lacking Expression of p53: Necrosis vs. Apoptosis

Differential substrate properties of mammalian ribonucleotide reductase

Effects of 2',2'-difluorodeoxycytidine (Gemcitabine) on wild type and variant mouse leukemia L1210 cells

Lactacystin, a proteasome inhibitor, potentiates the apoptotic effect of parthenolide, an inhibitor of NFkappaB activation, on drug-resistant mouse leukemia L1210 cells

5-(3-carboxymethoxyphenyl)-2-(4,5-dimethylthiazolyl)-3-(4-sulfophenyl)tetrazolium, inner salt (MTS) and related analogs of 3-(4,5-dimethylthiazolyl)-2,5-diphenyltetrazolium bromide (MTT) reducing to purple water-soluble formazans As cell-viability indicators

Blockage of Cyclin cdk's, PKC and Phosphoinositol 3-kinase Pathways Leads to Augmentation of Apoptosis in Drug-resistant Leukemia Cells: Evidence for Interactive Effects of Flavopiridol, LY 294002, Roscovitine, Wortmannin and UCN-01

Phenolic Compounds, Sodium Salicylate and Related Compounds, as Inhibitors of Tumor Cell Growth and Inducers of Apoptosis in Mouse Leukemia L1210 Cells

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