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TRP channels and pain

Current pharmaceutical design, 2009-05, Vol.15 (15), p.1736-1749

2009

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The vanilloid receptor TRPV1: 10 years from channel cloning to antagonist proof-of-concept

Nature reviews. Drug discovery, 2007-05, Vol.6 (5), p.357-372

2007

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Excitatory Monocyte Chemoattractant Protein-1 Signaling Is Up-Regulated in Sensory Neurons after Chronic Compression of the Dorsal Root Ganglion

Proceedings of the National Academy of Sciences - PNAS, 2005-09, Vol.102 (39), p.14092-14097

2005

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Distribution of mRNA for Vanilloid Receptor Subtype 1 (VR1), and VR1-Like Immunoreactivity, in the Central Nervous System of the Rat and Human

Proceedings of the National Academy of Sciences - PNAS, 2000-03, Vol.97 (7), p.3655-3660

2000

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Biochemical pharmacology of the vanilloid receptor TRPV1. An update

European journal of biochemistry, 2004-05, Vol.271 (10), p.1814-1819

2004

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TRP channels and pain

Biochimica et biophysica acta, 2007-08, Vol.1772 (8), p.978-988

2007

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Inflammation-induced reduction of spontaneous activity by adjuvant: A novel model to study the effect of analgesics in rats

The Journal of pharmacology and experimental therapeutics, 2007-01, Vol.320 (1), p.194-201

2007

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Characterization of N-(adamantan-1-ylmethyl)-5-[(3R-amino-pyrrolidin-1-yl)methyl]-2-chloro-benzamide, a P2X7 antagonist in animal models of pain and inflammation

The Journal of pharmacology and experimental therapeutics, 2008-12, Vol.327 (3), p.620

2008

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C5a, But Not C3a, Increases VEGF Secretion in ARPE-19 Human Retinal Pigment Epithelial Cells

Current eye research, 2009, Vol.34 (1), p.57-61

2009

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Distribution of mRNA for vanilloid receptor subtype 1 (VR1), and VR1-like immunoreactivity, in the central nervous system of the rat and human

Proceedings of the National Academy of Sciences - PNAS, 2000-03, Vol.97 (7), p.3655-3660

2000

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Identification and characterization of NDT 9513727 [N,N-bis(1,3-benzodioxol-5-ylmethyl)-1-butyl-2,4-diphenyl-1H-imidazole-5-methanamine], a novel, orally bioavailable C5a receptor inverse agonist

The Journal of pharmacology and experimental therapeutics, 2008-12, Vol.327 (3), p.898-909

2008

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Leukocyte Effects of C5a-Receptor Blockade During Simulated Extracorporeal Circulation

The Annals of thoracic surgery, 2007, Vol.83 (1), p.146-152

2007

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Hunting for ion channel modulators with herpes simplex virus

Nature methods, 2007-09, Vol.4 (9), p.692-693

2007

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The vanilloid receptor TRPV1: 10 years from channel cloning to antagonist proof-of-concept

Nature reviews. Drug discovery, 2007-05, Vol.6 (5), p.1-1

2007

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Locomotor activity in a novel environment as a test of inflammatory pain in rats

Methods in molecular biology (Clifton, N.J.), 2010-01, Vol.617, p.67

2010

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The Cloned Rat Vanilloid Receptor VR1 Mediates Both R-Type Binding and C-Type Calcium Response in Dorsal Root Ganglion Neurons

Molecular pharmacology, 1999-09, Vol.56 (3), p.581-587

1999

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New frontiers in assessing pain and analgesia in laboratory animals

Expert opinion on drug discovery, 2008-09, Vol.3 (9), p.1099-1108

2008

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The Tissue Distribution and Functional Characterization of Human VR1

Biochemical and biophysical research communications, 2001-03, Vol.281 (5), p.1183-1189

2001

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Formalin- or adjuvant-induced peripheral inflammation increases neurokinin-1 receptor gene expression in the mouse

Brain research, 2003-01, Vol.961 (1), p.147-152

2003

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Transient receptor potential ion channels as targets for the discovery of pain therapeutics

Current opinion in investigational drugs (London, England : 2000), 2005-01, Vol.6 (1), p.48

2005

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Substance P and neurokinin-1 receptor expression by intrinsic airway neurons in the rat

American journal of physiology. Lung cellular and molecular physiology, 2000-02, Vol.278 (2), p.344-L355

2000

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Molecular and biochemical characterization of the mouse brain corticotropin-releasing hormone-binding protein

Molecular and cellular endocrinology, 1995-06, Vol.111 (2), p.147-157

1995

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Discovery of Novel 6,6-Heterocycles as Transient Receptor Potential Vanilloid (TRPV1) Antagonists

Journal of medicinal chemistry, 2010-04, Vol.53 (8), p.3330-3348

2010

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Hunting for ion channel modulators with herpes simplex virus: an innovative use of HSV-1 vectors lays the foundation for a novel genetic screen for modulators of ligand-gated ion channels

Nature methods, 2007-09, Vol.4 (9), p.692

2007

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Pyrido[2,3-b]pyrazines, discovery of TRPV1 antagonists with reduced potential for the formation of reactive metabolites

Bioorganic & medicinal chemistry letters, 2010-08, Vol.20 (15), p.4359-4363

2010

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TRP channels and pain

The vanilloid receptor TRPV1: 10 years from channel cloning to antagonist proof-of-concept

Excitatory Monocyte Chemoattractant Protein-1 Signaling Is Up-Regulated in Sensory Neurons after Chronic Compression of the Dorsal Root Ganglion

Distribution of mRNA for Vanilloid Receptor Subtype 1 (VR1), and VR1-Like Immunoreactivity, in the Central Nervous System of the Rat and Human

Biochemical pharmacology of the vanilloid receptor TRPV1. An update

TRP channels and pain

Inflammation-induced reduction of spontaneous activity by adjuvant: A novel model to study the effect of analgesics in rats

Characterization of N-(adamantan-1-ylmethyl)-5-[(3R-amino-pyrrolidin-1-yl)methyl]-2-chloro-benzamide, a P2X7 antagonist in animal models of pain and inflammation

C5a, But Not C3a, Increases VEGF Secretion in ARPE-19 Human Retinal Pigment Epithelial Cells

Distribution of mRNA for vanilloid receptor subtype 1 (VR1), and VR1-like immunoreactivity, in the central nervous system of the rat and human

Identification and characterization of NDT 9513727 [N,N-bis(1,3-benzodioxol-5-ylmethyl)-1-butyl-2,4-diphenyl-1H-imidazole-5-methanamine], a novel, orally bioavailable C5a receptor inverse agonist

Leukocyte Effects of C5a-Receptor Blockade During Simulated Extracorporeal Circulation

Hunting for ion channel modulators with herpes simplex virus

The vanilloid receptor TRPV1: 10 years from channel cloning to antagonist proof-of-concept

Locomotor activity in a novel environment as a test of inflammatory pain in rats

The Cloned Rat Vanilloid Receptor VR1 Mediates Both R-Type Binding and C-Type Calcium Response in Dorsal Root Ganglion Neurons

New frontiers in assessing pain and analgesia in laboratory animals

The Tissue Distribution and Functional Characterization of Human VR1

Formalin- or adjuvant-induced peripheral inflammation increases neurokinin-1 receptor gene expression in the mouse

Transient receptor potential ion channels as targets for the discovery of pain therapeutics

Substance P and neurokinin-1 receptor expression by intrinsic airway neurons in the rat

Molecular and biochemical characterization of the mouse brain corticotropin-releasing hormone-binding protein

Discovery of Novel 6,6-Heterocycles as Transient Receptor Potential Vanilloid (TRPV1) Antagonists

Hunting for ion channel modulators with herpes simplex virus: an innovative use of HSV-1 vectors lays the foundation for a novel genetic screen for modulators of ligand-gated ion channels

Pyrido[2,3-b]pyrazines, discovery of TRPV1 antagonists with reduced potential for the formation of reactive metabolites

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