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Inhaled Treprostinil-Prodrug Lipid Nanoparticle Formulations Provide Long-Acting Pulmonary Vasodilation

Drug research, 2018-11, Vol.68 (11), p.605

2018

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Assessment of Inhaled Treprostinil Palmitil, Inhaled and Intravenous Treprostinil, and Oral Selexipag in a Sugen/Hypoxia Rat Model of Pulmonary Arterial Hypertension

The Journal of pharmacology and experimental therapeutics, 2022-10, Vol.383 (1), p.103

2022

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Treprostinil palmitil inhibits the hemodynamic and histopathological changes in the pulmonary vasculature and heart in an animal model of pulmonary arterial hypertension

European journal of pharmacology, 2022-02, Vol.916, p.174484, Article 174484

2022

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Strategies to Overcome Biological Barriers Associated with Pulmonary Drug Delivery

Pharmaceutics, 2022-01, Vol.14 (2), p.302

2022

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Development and Characterization of Treprostinil Palmitil Inhalation Aerosol for the Investigational Treatment of Pulmonary Arterial Hypertension

International journal of molecular sciences, 2021-01, Vol.22 (2), p.548

2021

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Therapeutic administration of inhaled INS1009, a treprostinil prodrug formulation, inhibits bleomycin-induced pulmonary fibrosis in rats

Pulmonary pharmacology & therapeutics, 2018-04, Vol.49, p.95-103

2018

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An overview of the biology of a long-acting inhaled treprostinil prodrug

Pulmonary pharmacology & therapeutics, 2020-12, Vol.65, p.102002-102002, Article 102002

2020

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Prostanoid receptor subtypes involved in treprostinil-mediated vasodilation of rat pulmonary arteries and in treprostinil-mediated inhibition of collagen gene expression of human lung fibroblasts

Prostaglandins & other lipid mediators, 2021-02, Vol.152, p.106486, Article 106486

2021

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Development and Preclinical Evaluation of New Inhaled Lipoglycopeptides for the Treatment of Persistent Pulmonary Methicillin-Resistant Staphylococcus aureus Infections

Antimicrobial agents and chemotherapy, 2021-06, Vol.65 (7), p.e0031621-e0031621

2021

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Correction for Plaunt et al., “Development and Preclinical Evaluation of New Inhaled Lipoglycopeptides for the Treatment of Persistent Pulmonary Methicillin-Resistant Staphylococcus aureus Infections”

Antimicrobial agents and chemotherapy, 2022-11, Vol.66 (11), p.e0125622-e0125622

2022

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Treprostinil palmitil, an inhaled long-acting pulmonary vasodilator, does not show tachyphylaxis with daily dosing in rats

Pulmonary pharmacology & therapeutics, 2021-02, Vol.66, p.101983-101983, Article 101983

2021

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Preclinical Pharmacology and Pharmacokinetics of Inhaled Hexadecyl-Treprostinil (C16TR), a Pulmonary Vasodilator Prodrug

The Journal of pharmacology and experimental therapeutics, 2017-12, Vol.363 (3), p.348

2017

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Characterisation of cough evoked by inhaled treprostinil and treprostinil palmitil

ERJ open research, 2021-01, Vol.7 (1), p.592

2021

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Inhaled hexadecyl-treprostinil provides pulmonary vasodilator activity at significantly lower plasma concentrations than infused treprostinil

Pulmonary pharmacology & therapeutics, 2018-04, Vol.49, p.104-111

2018

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Tachykinin NK 3 and NK 1 receptor activation elicits secretion from porcine airway submucosal glands

British journal of pharmacology, 2009-02, Vol.138 (1), p.254-260

2009

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Neuromodulation mediated by the tachykinin NK3-receptor agonist [MePhe7]-neurokinin B in the isolated perfused lung of nonsensitized nonchallenged and ovalbumin-sensitized and -challenged guinea pig

Experimental lung research, 2012-06, Vol.38 (5), p.233-249

2012

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Role of α2-adrenoceptors in electrical field stimulation-induced contraction of pig nasal mucosa and pharmacologic characterization of a novel α2C-adrenoceptor agonist

American journal of rhinology & allergy, 2013-03, Vol.27 (2), p.84

2013

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Three-dimensional analysis of rodent paranasal sinus cavities from X-ray computed tomography (CT) scans

Canadian journal of veterinary research, 2009-07, Vol.73 (3), p.205-211

2009

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Bronchoconstrictor effect of the tachykinin NK3-receptor agonists [MePhe7]-neurokinin B and senktide in the isolated guinea pig lung

Experimental lung research, 2010-11, Vol.36 (9), p.509-521

2010

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Mechanism of substance P-induced liquid secretion across bronchial epithelium

American journal of physiology. Lung cellular and molecular physiology, 2001-09, Vol.281 (3), p.639-L645

2001

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The synthesis and structure-activity relationship of 4-benzimidazolyl-piperidinylcarbonyl-piperidine analogs as histamine H3 antagonists

Bioorganic & medicinal chemistry letters, 2010-09, Vol.20 (17), p.5004-5008

2010

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Alpha-2c-Adrenergic Receptors Contribute to Basal Nasal Patency in the Anesthetized Cat

Pharmacology, 2010-01, Vol.85 (5), p.259-263

2010

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Introduction to the pulmonary research group's symposium upper airway disease: Clinical and research perspectives

Pulmonary pharmacology & therapeutics, 2008-01, Vol.21 (3), p.431-432

2008

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Nociceptin/orphanin FQ inhibits capsaicin‐induced guinea‐pig airway contraction through an inward‐rectifier potassium channel

British journal of pharmacology, 2002-02, Vol.135 (3), p.764-770

2002

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Nociceptin inhibits capsaicin-induced bronchoconstriction in isolated guinea pig lung

European journal of pharmacology, 2000-08, Vol.402 (1), p.171-179

2000

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Inhaled Treprostinil-Prodrug Lipid Nanoparticle Formulations Provide Long-Acting Pulmonary Vasodilation

Assessment of Inhaled Treprostinil Palmitil, Inhaled and Intravenous Treprostinil, and Oral Selexipag in a Sugen/Hypoxia Rat Model of Pulmonary Arterial Hypertension

Treprostinil palmitil inhibits the hemodynamic and histopathological changes in the pulmonary vasculature and heart in an animal model of pulmonary arterial hypertension

Strategies to Overcome Biological Barriers Associated with Pulmonary Drug Delivery

Development and Characterization of Treprostinil Palmitil Inhalation Aerosol for the Investigational Treatment of Pulmonary Arterial Hypertension

Therapeutic administration of inhaled INS1009, a treprostinil prodrug formulation, inhibits bleomycin-induced pulmonary fibrosis in rats

An overview of the biology of a long-acting inhaled treprostinil prodrug

Prostanoid receptor subtypes involved in treprostinil-mediated vasodilation of rat pulmonary arteries and in treprostinil-mediated inhibition of collagen gene expression of human lung fibroblasts

Development and Preclinical Evaluation of New Inhaled Lipoglycopeptides for the Treatment of Persistent Pulmonary Methicillin-Resistant Staphylococcus aureus Infections

Correction for Plaunt et al., “Development and Preclinical Evaluation of New Inhaled Lipoglycopeptides for the Treatment of Persistent Pulmonary Methicillin-Resistant Staphylococcus aureus Infections”

Treprostinil palmitil, an inhaled long-acting pulmonary vasodilator, does not show tachyphylaxis with daily dosing in rats

Preclinical Pharmacology and Pharmacokinetics of Inhaled Hexadecyl-Treprostinil (C16TR), a Pulmonary Vasodilator Prodrug

Characterisation of cough evoked by inhaled treprostinil and treprostinil palmitil

Inhaled hexadecyl-treprostinil provides pulmonary vasodilator activity at significantly lower plasma concentrations than infused treprostinil

Tachykinin NK 3 and NK 1 receptor activation elicits secretion from porcine airway submucosal glands

Neuromodulation mediated by the tachykinin NK3-receptor agonist [MePhe7]-neurokinin B in the isolated perfused lung of nonsensitized nonchallenged and ovalbumin-sensitized and -challenged guinea pig

Role of α2-adrenoceptors in electrical field stimulation-induced contraction of pig nasal mucosa and pharmacologic characterization of a novel α2C-adrenoceptor agonist

Three-dimensional analysis of rodent paranasal sinus cavities from X-ray computed tomography (CT) scans

Bronchoconstrictor effect of the tachykinin NK3-receptor agonists [MePhe7]-neurokinin B and senktide in the isolated guinea pig lung

Mechanism of substance P-induced liquid secretion across bronchial epithelium

The synthesis and structure-activity relationship of 4-benzimidazolyl-piperidinylcarbonyl-piperidine analogs as histamine H3 antagonists

Alpha-2c-Adrenergic Receptors Contribute to Basal Nasal Patency in the Anesthetized Cat

Introduction to the pulmonary research group's symposium upper airway disease: Clinical and research perspectives

Nociceptin/orphanin FQ inhibits capsaicin‐induced guinea‐pig airway contraction through an inward‐rectifier potassium channel

Nociceptin inhibits capsaicin-induced bronchoconstriction in isolated guinea pig lung

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