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Evolution of new enzymes by gene duplication and divergence

The FEBS journal, 2020-04, Vol.287 (7), p.1262-1283

Copley, Shelley D.

2020

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An evolutionary biochemist's perspective on promiscuity

Trends in biochemical sciences (Amsterdam. Regular ed.), 2015-02, Vol.40 (2), p.72-78

Copley, Shelley D.

2015

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Moonlighting is mainstream: Paradigm adjustment required

BioEssays, 2012-07, Vol.34 (7), p.578-588

Copley, Shelley D.

2012

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Evolution of efficient pathways for degradation of anthropogenic chemicals

Nature chemical biology, 2009-08, Vol.5 (8), p.559-566

Copley, Shelley D

2009

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An evolutionary perspective on protein moonlighting

Biochemical Society transactions, 2014-12, Vol.42 (6), p.1684-1691

Copley, Shelley D

2014

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Synonymous mutations make dramatic contributions to fitness when growth is limited by a weak-link enzyme

PLoS genetics, 2018-08, Vol.14 (8), p.e1007615-e1007615

2018

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Reactivity landscape of pyruvate under simulated hydrothermal vent conditions

Proceedings of the National Academy of Sciences - PNAS, 2013-08, Vol.110 (33), p.13283-13288

2013

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Shining a light on enzyme promiscuity

Current opinion in structural biology, 2017-12, Vol.47, p.167-175

Copley, Shelley D

2017

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Inhibitory cross-talk upon introduction of a new metabolic pathway into an existing metabolic network

Proceedings of the National Academy of Sciences - PNAS, 2012-10, Vol.109 (42), p.E2856-E2864

2012

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Sequestration of a highly reactive intermediate in an evolving pathway for degradation of pentachlorophenol

Proceedings of the National Academy of Sciences - PNAS, 2013-06, Vol.110 (24), p.E2182-E2190

2013

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Three serendipitous pathways in E. coli can bypass a block in pyridoxal-5′-phosphate synthesis

Molecular systems biology, 2010-11, Vol.6 (1), p.436-n/a

2010

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compromise required by gene sharing enables survival: Implications for evolution of new enzyme activities

Proceedings of the National Academy of Sciences - PNAS, 2008-09, Vol.105 (36), p.13497-13502

2008

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A versatile and highly efficient method for scarless genome editing in Escherichia coli and Salmonella enterica

BMC biotechnology, 2014-09, Vol.14 (1), p.84-84, Article 84

2014

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Mutations that improve efficiency of a weak-link enzyme are rare compared to adaptive mutations elsewhere in the genome

eLife, 2019-12, Vol.8

2019

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Genome shuffling improves degradation of the anthropogenic pesticide pentachlorophenol by Sphingobium chlorophenolicum ATCC 39723

Applied and Environmental Microbiology, 2004-04, Vol.70 (4), p.2391-2397

2004

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The physical basis and practical consequences of biological promiscuity

Physical biology, 2020-04, Vol.17 (5), p.51001

Copley, Shelley D

2020

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Toward a Systems Biology Perspective on Enzyme Evolution

The Journal of biological chemistry, 2012-01, Vol.287 (1), p.3-10

Copley, Shelley D.

2012

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Why Metabolic Enzymes Are Essential or Nonessential for Growth of Escherichia coli K12 on Glucose

Biochemistry (Easton), 2007-11, Vol.46 (44), p.12501-12511

2007

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Evolution of a metabolic pathway for degradation of a toxic xenobiotic: the patchwork approach

Trends in biochemical sciences (Amsterdam. Regular ed.), 2000-06, Vol.25 (6), p.261-265

Copley, Shelley D

2000

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Divergence of Function in the Thioredoxin Fold Suprafamily: Evidence for Evolution of Peroxiredoxins from a Thioredoxin-like Ancestor

Biochemistry (Easton), 2004-11, Vol.43 (44), p.13981-13995

2004

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Genome-Wide Analysis of Transcriptional Changes and Genes That Contribute to Fitness during Degradation of the Anthropogenic Pollutant Pentachlorophenol by Sphingobium chlorophenolicum

mSystems, 2018-11, Vol.3 (6)

2018

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How to Recruit a Promiscuous Enzyme to Serve a New Function

Biochemistry (Easton), 2023-01, Vol.62 (2), p.300-308

2023

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A Mechanism for the Association of Amino Acids with Their Codons and the Origin of the Genetic Code

Proceedings of the National Academy of Sciences - PNAS, 2005-03, Vol.102 (12), p.4442-4447

2005

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Lateral gene transfer and parallel evolution in the history of glutathione biosynthesis genes

Genome biology, 2002-01, Vol.3 (5), p.research0025-research0025, Article research0025.1

2002

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Enzymes with extra talents: moonlighting functions and catalytic promiscuity

Current opinion in chemical biology, 2003-04, Vol.7 (2), p.265-272

Copley, Shelley D

2003

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Evolution of new enzymes by gene duplication and divergence

An evolutionary biochemist's perspective on promiscuity

Moonlighting is mainstream: Paradigm adjustment required

Evolution of efficient pathways for degradation of anthropogenic chemicals

An evolutionary perspective on protein moonlighting

Synonymous mutations make dramatic contributions to fitness when growth is limited by a weak-link enzyme

Reactivity landscape of pyruvate under simulated hydrothermal vent conditions

Shining a light on enzyme promiscuity

Inhibitory cross-talk upon introduction of a new metabolic pathway into an existing metabolic network

Sequestration of a highly reactive intermediate in an evolving pathway for degradation of pentachlorophenol

Three serendipitous pathways in E. coli can bypass a block in pyridoxal-5′-phosphate synthesis

compromise required by gene sharing enables survival: Implications for evolution of new enzyme activities

A versatile and highly efficient method for scarless genome editing in Escherichia coli and Salmonella enterica

Mutations that improve efficiency of a weak-link enzyme are rare compared to adaptive mutations elsewhere in the genome

Genome shuffling improves degradation of the anthropogenic pesticide pentachlorophenol by Sphingobium chlorophenolicum ATCC 39723

The physical basis and practical consequences of biological promiscuity

Toward a Systems Biology Perspective on Enzyme Evolution

Why Metabolic Enzymes Are Essential or Nonessential for Growth of Escherichia coli K12 on Glucose

Evolution of a metabolic pathway for degradation of a toxic xenobiotic: the patchwork approach

Divergence of Function in the Thioredoxin Fold Suprafamily: Evidence for Evolution of Peroxiredoxins from a Thioredoxin-like Ancestor

Genome-Wide Analysis of Transcriptional Changes and Genes That Contribute to Fitness during Degradation of the Anthropogenic Pollutant Pentachlorophenol by Sphingobium chlorophenolicum

How to Recruit a Promiscuous Enzyme to Serve a New Function

A Mechanism for the Association of Amino Acids with Their Codons and the Origin of the Genetic Code

Lateral gene transfer and parallel evolution in the history of glutathione biosynthesis genes

Enzymes with extra talents: moonlighting functions and catalytic promiscuity

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