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Structure of class B GPCR corticotropin-releasing factor receptor 1

Nature (London), 2013-07, Vol.499 (7459), p.438-443

2013

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Structure of the complement C5a receptor bound to the extra-helical antagonist NDT9513727

Nature (London), 2018-01, Vol.553 (7686), p.111-114

2018

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Structure of class C GPCR metabotropic glutamate receptor 5 transmembrane domain

Nature (London), 2014-07, Vol.511 (7511), p.557-562

2014

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Structures of G protein-coupled receptors reveal new opportunities for drug discovery

Drug discovery today, 2015-11, Vol.20 (11), p.1355-1364

2015

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Serial millisecond crystallography for routine room-temperature structure determination at synchrotrons

Nature communications, 2017-09, Vol.8 (1), p.542-11, Article 542

2017

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Controlling the Dissociation of Ligands from the Adenosine A2A Receptor through Modulation of Salt Bridge Strength

Journal of medicinal chemistry, 2016-07, Vol.59 (13), p.6470-6479

2016

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Extra-helical binding site of a glucagon receptor antagonist

Nature (London), 2016-05, Vol.533 (7602), p.274-277

2016

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Crystal structure of the GLP-1 receptor bound to a peptide agonist

Nature (London), 2017-06, Vol.546 (7657), p.254-258

2017

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Towards high throughput GPCR crystallography: In Meso soaking of Adenosine A2A Receptor crystals

Scientific reports, 2018-01, Vol.8 (1), p.1-41, Article 41

2018

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Kinetics for Drug Discovery: an industry-driven effort to target drug residence time

Drug discovery today, 2017-06, Vol.22 (6), p.896-911

2017

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Comparison of Orexin 1 and Orexin 2 Ligand Binding Modes Using X‑ray Crystallography and Computational Analysis

Journal of medicinal chemistry, 2020-02, Vol.63 (4), p.1528-1543

2020

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Structures of Human A1 and A2A Adenosine Receptors with Xanthines Reveal Determinants of Selectivity

Structure (London), 2017-08, Vol.25 (8), p.1275-1285.e4

2017

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Intracellular allosteric antagonism of the CCR9 receptor

Nature (London), 2016-12, Vol.540 (7633), p.462-465

2016

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Structural insight into allosteric modulation of protease-activated receptor 2

Nature (London), 2017-05, Vol.545 (7652), p.112-115

2017

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Preparation of purified GPCRs for structural studies

Biochemical Society transactions, 2013-02, Vol.41 (1), p.185

2013

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Structural Mapping of Adenosine Receptor Mutations: Ligand Binding and Signaling Mechanisms

Trends in pharmacological sciences (Regular ed.), 2018-01, Vol.39 (1), p.75-89

2018

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X‐Ray Crystallography and Free Energy Calculations Reveal the Binding Mechanism of A2A Adenosine Receptor Antagonists

Angewandte Chemie (International ed.), 2020-09, Vol.59 (38), p.16536-16543

International ed. in English, 2020

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Crystal Structure and Subsequent Ligand Design of a Nonriboside Partial Agonist Bound to the Adenosine A 2A Receptor

Journal of medicinal chemistry, 2021-04, Vol.64 (7), p.3827-3842

2021

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Biosensor-based affinities and binding kinetics of small molecule antagonists to the adenosine A(2A) receptor reconstituted in HDL like particles

FEBS letters, 2015-06, Vol.589 (13), p.1399-1405

2015

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Biosensor-based affinities and binding kinetics of small molecule antagonists to the adenosine A2A receptor reconstituted in HDL like particles

FEBS letters, 2015-06, Vol.589 (13), p.1399-1405

2015

Volltextzugriff (PDF)

Crystal Structure and Subsequent Ligand Design of a Nonriboside Partial Agonist Bound to the Adenosine A2A Receptor

Journal of medicinal chemistry, 2021-04, Vol.64 (7), p.3827-3842

2021

Volltextzugriff (PDF)

X-Ray Crystallography and Free Energy Calculations Reveal the Binding Mechanism of A 2A Adenosine Receptor Antagonists

Angewandte Chemie International Edition, 2020-09, Vol.59 (38), p.16536-16543

2020

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Identification of a Glycosaminoglycan Binding Surface on Human Interleukin-8

Biochemistry (Easton), 1998-08, Vol.37 (32), p.11193-11201

1998

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Structures of Human A 1 and A 2A Adenosine Receptors with Xanthines Reveal Determinants of Selectivity

Structure (London), 2017-08, Vol.25 (8), p.1275-1285.e4

2017

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Identification of a novel allosteric GLP-1R antagonist HTL26119 using structure-based drug design

Bioorganic & medicinal chemistry letters, 2019-10, Vol.29 (20), p.126611-126611, Article 126611

2019

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Structure of class B GPCR corticotropin-releasing factor receptor 1

Structure of the complement C5a receptor bound to the extra-helical antagonist NDT9513727

Structure of class C GPCR metabotropic glutamate receptor 5 transmembrane domain

Structures of G protein-coupled receptors reveal new opportunities for drug discovery

Serial millisecond crystallography for routine room-temperature structure determination at synchrotrons

Controlling the Dissociation of Ligands from the Adenosine A2A Receptor through Modulation of Salt Bridge Strength

Extra-helical binding site of a glucagon receptor antagonist

Crystal structure of the GLP-1 receptor bound to a peptide agonist

Towards high throughput GPCR crystallography: In Meso soaking of Adenosine A2A Receptor crystals

Kinetics for Drug Discovery: an industry-driven effort to target drug residence time

Comparison of Orexin 1 and Orexin 2 Ligand Binding Modes Using X‑ray Crystallography and Computational Analysis

Structures of Human A1 and A2A Adenosine Receptors with Xanthines Reveal Determinants of Selectivity

Intracellular allosteric antagonism of the CCR9 receptor

Structural insight into allosteric modulation of protease-activated receptor 2

Preparation of purified GPCRs for structural studies

Structural Mapping of Adenosine Receptor Mutations: Ligand Binding and Signaling Mechanisms

X‐Ray Crystallography and Free Energy Calculations Reveal the Binding Mechanism of A2A Adenosine Receptor Antagonists

Crystal Structure and Subsequent Ligand Design of a Nonriboside Partial Agonist Bound to the Adenosine A 2A Receptor

Biosensor-based affinities and binding kinetics of small molecule antagonists to the adenosine A(2A) receptor reconstituted in HDL like particles

Biosensor-based affinities and binding kinetics of small molecule antagonists to the adenosine A2A receptor reconstituted in HDL like particles

Crystal Structure and Subsequent Ligand Design of a Nonriboside Partial Agonist Bound to the Adenosine A2A Receptor

X-Ray Crystallography and Free Energy Calculations Reveal the Binding Mechanism of A 2A Adenosine Receptor Antagonists

Identification of a Glycosaminoglycan Binding Surface on Human Interleukin-8

Structures of Human A 1 and A 2A Adenosine Receptors with Xanthines Reveal Determinants of Selectivity

Identification of a novel allosteric GLP-1R antagonist HTL26119 using structure-based drug design

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