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Inhibition of Colony-Stimulating-Factor-1 Signaling in vivo with the Orally Bioavailable cFMS Kinase Inhibitor GW2580

Proceedings of the National Academy of Sciences - PNAS, 2005-11, Vol.102 (44), p.16078-16083

2005

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Effects of the cFMS kinase inhibitor 5-(3-methoxy-4-((4-methoxybenzyl)oxy)benzyl)pyrimidine-2,4-diamine (GW2580) in normal and arthritic rats

The Journal of pharmacology and experimental therapeutics, 2008-07, Vol.326 (1), p.41

2008

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4-Bicyclic heteroaryl-piperidine derivatives as potent, orally bioavailable stearoyl-CoA desaturase-1 (SCD1) inhibitors: part 2. Pyridazine-based analogs

Bioorganic & medicinal chemistry letters, 2014-03, Vol.24 (5), p.1437-1441

2014

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4-Bicyclic heteroaryl-piperidine derivatives as potent, orally bioavailable Stearoyl-CoA desaturase-1 (SCD1) inhibitors. Part 1: Urea-based analogs

Bioorganic & medicinal chemistry letters, 2013-12, Vol.23 (24), p.6773-6776

2013

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Regulation of tumour necrosis factor-α processing by a metalloproteinase inhibitor

Nature (London), 1994-08, Vol.370 (6490), p.558-561

1994

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Design of Selective and Soluble Inhibitors of Tumor Necrosis Factor-α Converting Enzyme (TACE)

Journal of medicinal chemistry, 2001-11, Vol.44 (24), p.4252-4267

2001

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Relationship of hepatic peroxisome proliferation and replicative DNA synthesis to the hepatocarcinogenicity of the peroxisome proliferators Di(2-ethylhexyl)phthalate and [4-chloro-6-(2,3-xylidino)-2-pyrimidinylthio]acetic acid (Wy-14,643) in rats

Cancer research (Chicago, Ill.), 1988-12, Vol.48 (23), p.6739-6744

1988

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Regulation of TNF-α secretion by a specific melanocortin-1 receptor peptide agonist

Peptides (New York, N.Y. : 1980), 2003-05, Vol.24 (5), p.709-716

2003

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The Effects of the Symbiont Rickettsia on the Interactions between a Whitefly Pest (Bemisia tabaci) and a General Fungal Pathogen (Beauveria bassiana)

Conway, James G

2017

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Inhibition of tumor necrosis factor-alpha (TNF-alpha) production and arthritis in the rat by GW3333, a dual inhibitor of TNF-alpha-converting enzyme and matrix metalloproteinases

The Journal of pharmacology and experimental therapeutics, 2001-09, Vol.298 (3), p.900

2001

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Middle Atmosphere Dynamics

1, 1987

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Microcirculation of hepatic nodules from diethylnitrosamine-treated rats

Cancer research (Chicago, Ill.), 1985-08, Vol.45 (8), p.3620-3625

1985

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Role of fatty acyl coenzyme A oxidase in the efflux of oxidized glutathione from perfused livers of rats treated with the peroxisome proliferator nafenopin

Cancer research (Chicago, Ill.), 1987-09, Vol.47 (18), p.4795

1987

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Effect of size on portal circulation of hepatic nodules from carcinogen-treated rats

Cancer research (Chicago, Ill.), 1983-07, Vol.43 (7), p.3374

1983

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Inhibition of cartilage and bone destruction in adjuvant arthritis in the rat by a matrix metalloproteinase inhibitor

The Journal of experimental medicine, 1995-08, Vol.182 (2), p.449-457

1995

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N-Hydroxyformamide peptidomimetics as TACE/Matrix metalloprotease inhibitors: oral activity via P1′ isobutyl substitution

Bioorganic & medicinal chemistry letters, 2001-08, Vol.11 (16), p.2147-2151

2001

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Relationship of oxidative damage to the hepatocarcinogenicity of the peroxisome proliferators di(2-ethylhexyl)phthalate and Wy-14,643

Carcinogenesis (New York), 1989-03, Vol.10 (3), p.513-519

1989

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Association of persistent peroxisome proliferation and oxidative injury with hepatocarcinogenicity in female F-334 rats fed di(2-ethylhexyl)phthalate for 2 years

Cancer letters, 1987, Vol.38 (1), p.15-22

1987

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Effect of the Hepatocarcinogenic Peroxisome Proliferator Wy-14,643 in Vivo: No Increase in Ethane Exhalation or Hepatic Conjugated Dienes

Toxicology and applied pharmacology, 1995-12, Vol.135 (2), p.229-236

1995

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Possible Mechanisms in Hepatocarcinogensis by the Peroxisome Proliferator Di(2-Ethylhexyl)Phthalate

Drug metabolism reviews, 1989, Vol.21 (1), p.65-102

1989

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Effect of matrix metalloproteinase inhibitors on tumor growth and spontaneous metastasis

Clinical & experimental metastasis, 1996-03, Vol.14 (2), p.115-124

1996

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Regulation of tumour necrosis factor- alpha processing by a metallproteinase inhibitor

Nature (London), 1994-01, Vol.370 (6490), p.558-561

1994

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Carcinogen treatment increases glutathione hydrolysis by γ-glutamyl transpeptidase

Carcinogenesis (New York), 1987-07, Vol.8 (7), p.999-1004

1987

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Stimulation of mixed-function oxidation by NADPH in perfused mouse livers

Biochemical pharmacology, 1986-10, Vol.35 (20), p.3607-3612

1986

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Maintenance of nicotinamide dinucleotide phosphate content and oxidation-reduction state during mixed-function oxidation of p-nitroanisole in isolated perfused livers of various species

Biochemical pharmacology, 1987-04, Vol.36 (7), p.1083-1090

1987

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Inhibition of Colony-Stimulating-Factor-1 Signaling in vivo with the Orally Bioavailable cFMS Kinase Inhibitor GW2580

Effects of the cFMS kinase inhibitor 5-(3-methoxy-4-((4-methoxybenzyl)oxy)benzyl)pyrimidine-2,4-diamine (GW2580) in normal and arthritic rats

4-Bicyclic heteroaryl-piperidine derivatives as potent, orally bioavailable stearoyl-CoA desaturase-1 (SCD1) inhibitors: part 2. Pyridazine-based analogs

4-Bicyclic heteroaryl-piperidine derivatives as potent, orally bioavailable Stearoyl-CoA desaturase-1 (SCD1) inhibitors. Part 1: Urea-based analogs

Regulation of tumour necrosis factor-α processing by a metalloproteinase inhibitor

Design of Selective and Soluble Inhibitors of Tumor Necrosis Factor-α Converting Enzyme (TACE)

Relationship of hepatic peroxisome proliferation and replicative DNA synthesis to the hepatocarcinogenicity of the peroxisome proliferators Di(2-ethylhexyl)phthalate and [4-chloro-6-(2,3-xylidino)-2-pyrimidinylthio]acetic acid (Wy-14,643) in rats

Regulation of TNF-α secretion by a specific melanocortin-1 receptor peptide agonist

The Effects of the Symbiont Rickettsia on the Interactions between a Whitefly Pest (Bemisia tabaci) and a General Fungal Pathogen (Beauveria bassiana)

Inhibition of tumor necrosis factor-alpha (TNF-alpha) production and arthritis in the rat by GW3333, a dual inhibitor of TNF-alpha-converting enzyme and matrix metalloproteinases

Middle Atmosphere Dynamics

Microcirculation of hepatic nodules from diethylnitrosamine-treated rats

Role of fatty acyl coenzyme A oxidase in the efflux of oxidized glutathione from perfused livers of rats treated with the peroxisome proliferator nafenopin

Effect of size on portal circulation of hepatic nodules from carcinogen-treated rats

Inhibition of cartilage and bone destruction in adjuvant arthritis in the rat by a matrix metalloproteinase inhibitor

N-Hydroxyformamide peptidomimetics as TACE/Matrix metalloprotease inhibitors: oral activity via P1′ isobutyl substitution

Relationship of oxidative damage to the hepatocarcinogenicity of the peroxisome proliferators di(2-ethylhexyl)phthalate and Wy-14,643

Association of persistent peroxisome proliferation and oxidative injury with hepatocarcinogenicity in female F-334 rats fed di(2-ethylhexyl)phthalate for 2 years

Effect of the Hepatocarcinogenic Peroxisome Proliferator Wy-14,643 in Vivo: No Increase in Ethane Exhalation or Hepatic Conjugated Dienes

Possible Mechanisms in Hepatocarcinogensis by the Peroxisome Proliferator Di(2-Ethylhexyl)Phthalate

Effect of matrix metalloproteinase inhibitors on tumor growth and spontaneous metastasis

Regulation of tumour necrosis factor- alpha processing by a metallproteinase inhibitor

Carcinogen treatment increases glutathione hydrolysis by γ-glutamyl transpeptidase

Stimulation of mixed-function oxidation by NADPH in perfused mouse livers

Maintenance of nicotinamide dinucleotide phosphate content and oxidation-reduction state during mixed-function oxidation of p-nitroanisole in isolated perfused livers of various species

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