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Synthesis and structure-activity relationships for a new class of tetrahydronaphthalene amide inhibitors of Mycobacterium tuberculosis

European journal of medicinal chemistry, 2022-02, Vol.229, p.114059-114059, Article 114059

2022

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Recent Developments in Cell Permeable Deubiquitinating Enzyme Activity-Based Probes

Frontiers in chemistry, 2019-12, Vol.7, p.876-876

2019

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Synthetic Studies to Help Elucidate the Metabolism of the Preclinical Candidate TBAJ-876-A Less Toxic and More Potent Analogue of Bedaquiline

Molecules (Basel, Switzerland), 2020-03, Vol.25 (6), p.1423

2020

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A tubulin binding molecule drives differentiation of acute myeloid leukemia cells

iScience, 2022-08, Vol.25 (8), p.104787-104787, Article 104787

2022

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UCHL1 as a novel target in breast cancer: emerging insights from cell and chemical biology

British journal of cancer, 2022-01, Vol.126 (1), p.24-33

2022

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Riociguat: First Global Approval

Drugs (New York, N.Y.), 2013-11, Vol.73 (17), p.1967-1975

2013

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Colistimethate Sodium Dry Powder for Inhalation: A Review of Its Use in the Treatment of Chronic Pseudomonas aeruginosa Infection in Patients with Cystic Fibrosis

Drugs (New York, N.Y.), 2014-03, Vol.74 (3), p.377-387

2014

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The maturation of DNA encoded libraries: opportunities for new users

Future medicinal chemistry, 2021-01, Vol.13 (2), p.173-191

2021

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Non-Histone Protein Methylation: Biological Significance and Bioengineering Potential

ACS chemical biology, 2021-02, Vol.16 (2), p.238-250

2021

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3,5-Dialkoxypyridine analogues of bedaquiline are potent antituberculosis agents with minimal inhibition of the hERG channel

Bioorganic & medicinal chemistry, 2019-04, Vol.27 (7), p.1292-1307

2019

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Light-mediated multi-target protein degradation using arylazopyrazole photoswitchable PROTACs (AP-PROTACs)

Chemical communications (Cambridge, England), 2022-09, Vol.58 (78), p.1933-1936

2022

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Structure-activity relationships for analogs of the tuberculosis drug bedaquiline with the naphthalene unit replaced by bicyclic heterocycles

Bioorganic & medicinal chemistry, 2018-05, Vol.26 (8), p.1797-1809

2018

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Discovery of a Potent Deubiquitinase (DUB) Small‐Molecule Activity‐Based Probe Enables Broad Spectrum DUB Activity Profiling in Living Cells

Angewandte Chemie International Edition, 2023-11, Vol.62 (47), p.e202311190-n/a

International ed. in English, 2023

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Structure-Guided Design and Optimization of Covalent VHL-Targeted Sulfonyl Fluoride PROTACs

Journal of medicinal chemistry, 2024-03, Vol.67 (6), p.4641-4654

2024

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Structure-activity relationships for unit C pyridyl analogues of the tuberculosis drug bedaquiline

Bioorganic & medicinal chemistry, 2019-04, Vol.27 (7), p.1283-1291

2019

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A Series of Substituted Bis-Aminotriazines Are Activators of the Natriuretic Peptide Receptor C

Journal of medicinal chemistry, 2022-04, Vol.65 (7), p.5495-5513

2022

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Targeting STAT3 signaling using stabilised sulforaphane (SFX-01) inhibits endocrine resistant stem-like cells in ER-positive breast cancer

Oncogene, 2020-06, Vol.39 (25), p.4896-4908

2020

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Discovery of potent and selective activity-based probes (ABPs) for the deubiquitinating enzyme USP30

RSC chemical biology, 2024-05, Vol.5 (5), p.439-446

2024

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Synthesis and structure-activity relationships for tetrahydroisoquinoline-based inhibitors of Mycobacterium tuberculosis

Bioorganic & medicinal chemistry, 2020-11, Vol.28 (22), p.115784-115784, Article 115784

2020

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Structure-activity relationships of 2-pyrimidinecarbohydrazides as utrophin modulators for the potential treatment of Duchenne muscular dystrophy

Bioorganic & medicinal chemistry, 2022-09, Vol.69, p.116812-116812, Article 116812

2022

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Discovery and mechanism of action studies of 4,6-diphenylpyrimidine-2-carbohydrazides as utrophin modulators for the treatment of Duchenne muscular dystrophy

European journal of medicinal chemistry, 2021-08, Vol.220, p.113431-113431, Article 113431

2021

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6‑Cyano Analogues of Bedaquiline as Less Lipophilic and Potentially Safer Diarylquinolines for Tuberculosis

ACS medicinal chemistry letters, 2017-10, Vol.8 (10), p.1019-1024

2017

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Biophysical screening methods for extracellular domain peptide receptors, application to natriuretic peptide receptor C ligands

Chemical biology & drug design, 2019-06, Vol.93 (6), p.1011-1020

2019

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Chemical tools for profiling the intracellular ADP-ribosylated proteome

RSC chemical biology, 2024-07, Vol.5 (7), p.64-651

2024

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Discovery of a novel fluorescent chemical probe suitable for evaluation of neuropilin‐1 binding of small molecules

Drug development research, 2020-06, Vol.81 (4), p.491-500

2020

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Synthesis and structure-activity relationships for a new class of tetrahydronaphthalene amide inhibitors of Mycobacterium tuberculosis

Recent Developments in Cell Permeable Deubiquitinating Enzyme Activity-Based Probes

Synthetic Studies to Help Elucidate the Metabolism of the Preclinical Candidate TBAJ-876-A Less Toxic and More Potent Analogue of Bedaquiline

A tubulin binding molecule drives differentiation of acute myeloid leukemia cells

UCHL1 as a novel target in breast cancer: emerging insights from cell and chemical biology

Riociguat: First Global Approval

Colistimethate Sodium Dry Powder for Inhalation: A Review of Its Use in the Treatment of Chronic Pseudomonas aeruginosa Infection in Patients with Cystic Fibrosis

The maturation of DNA encoded libraries: opportunities for new users

Non-Histone Protein Methylation: Biological Significance and Bioengineering Potential

3,5-Dialkoxypyridine analogues of bedaquiline are potent antituberculosis agents with minimal inhibition of the hERG channel

Light-mediated multi-target protein degradation using arylazopyrazole photoswitchable PROTACs (AP-PROTACs)

Structure-activity relationships for analogs of the tuberculosis drug bedaquiline with the naphthalene unit replaced by bicyclic heterocycles

Discovery of a Potent Deubiquitinase (DUB) Small‐Molecule Activity‐Based Probe Enables Broad Spectrum DUB Activity Profiling in Living Cells

Structure-Guided Design and Optimization of Covalent VHL-Targeted Sulfonyl Fluoride PROTACs

Structure-activity relationships for unit C pyridyl analogues of the tuberculosis drug bedaquiline

A Series of Substituted Bis-Aminotriazines Are Activators of the Natriuretic Peptide Receptor C

Targeting STAT3 signaling using stabilised sulforaphane (SFX-01) inhibits endocrine resistant stem-like cells in ER-positive breast cancer

Discovery of potent and selective activity-based probes (ABPs) for the deubiquitinating enzyme USP30

Synthesis and structure-activity relationships for tetrahydroisoquinoline-based inhibitors of Mycobacterium tuberculosis

Structure-activity relationships of 2-pyrimidinecarbohydrazides as utrophin modulators for the potential treatment of Duchenne muscular dystrophy

Discovery and mechanism of action studies of 4,6-diphenylpyrimidine-2-carbohydrazides as utrophin modulators for the treatment of Duchenne muscular dystrophy

6‑Cyano Analogues of Bedaquiline as Less Lipophilic and Potentially Safer Diarylquinolines for Tuberculosis

Biophysical screening methods for extracellular domain peptide receptors, application to natriuretic peptide receptor C ligands

Chemical tools for profiling the intracellular ADP-ribosylated proteome

Discovery of a novel fluorescent chemical probe suitable for evaluation of neuropilin‐1 binding of small molecules

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