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Oncogenic PIK3CA mutations reprogram glutamine metabolism in colorectal cancer

Nature communications, 2016-06, Vol.7 (1), p.11971-11971, Article 11971

2016

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5-Fluorouracil Enhances the Antitumor Activity of the Glutaminase Inhibitor CB-839 against PIK3CA -Mutant Colorectal Cancers

Cancer research (Chicago, Ill.), 2020-11, Vol.80 (21), p.4815-4827

2020

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Colorectal cancers utilize glutamine as an anaplerotic substrate of the TCA cycle in vivo

Scientific reports, 2019-12, Vol.9 (1), p.19180-9, Article 19180

2019

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Lrp5 functions in bone to regulate bone mass

Nature medicine, 2011-06, Vol.17 (6), p.684-691

2011

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Delivering on the promise of gene editing for cystic fibrosis

Genes & diseases, 2019-06, Vol.6 (2), p.97-108

2019

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A G542X cystic fibrosis mouse model for examining nonsense mutation directed therapies

PloS one, 2018-06, Vol.13 (6), p.e0199573-e0199573

2018

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Nuclear translocation of p85β promotes tumorigenesis of PIK3CA helical domain mutant cancer

Nature communications, 2022-04, Vol.13 (1), p.1974-1974, Article 1974

2022

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An evolutionary driver of interspersed segmental duplications in primates

Genome Biology, 2020-08, Vol.21 (1), p.202-202, Article 202

2020

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Huntingtin facilitates polycomb repressive complex 2

Human molecular genetics, 2010-02, Vol.19 (4), p.573-583

2010

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PD-L1 expression is regulated by ATP-binding of the ERBB3 pseudokinase domain

Genes & diseases, 2023-07, Vol.10 (4), p.1702-1713

2023

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A requirement for Notch1 distinguishes 2 phases of definitive hematopoiesis during development

Blood, 2004-11, Vol.104 (10), p.3097-3105

2004

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Axial skeletal defects caused by mutation in the spondylocostal dysplasia/pudgy gene Dll3 are associated with disruption of the segmentation clock within the presomitic mesoderm

Development (Cambridge), 2002-04, Vol.129 (7), p.1795-1806

2002

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Phenotype Variation in Two-Locus Mouse Models of Hirschsprung Disease: Tissue-Specific Interaction between Ret and Ednrb

Proceedings of the National Academy of Sciences - PNAS, 2003-02, Vol.100 (4), p.1826-1831

2003

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Phosphoenolpyruvate carboxykinase and the critical role of cataplerosis in the control of hepatic metabolism

Nutrition & metabolism, 2005-11, Vol.2 (1), p.33-33, Article 33

2005

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Rhodopsin mislocalization drives ciliary dysregulation in a novel autosomal dominant retinitis pigmentosa knock‐in mouse model

The FASEB journal, 2024-04, Vol.38 (8), p.e23606-n/a

2024

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Suppression of proteolipid protein rescues Pelizaeus-Merzbacher disease

Nature (London), 2020-09, Vol.585 (7825), p.397-403

2020

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A mouse model of the protease-activated receptor 4 Pro310Leu variant has reduced platelet reactivity

Journal of thrombosis and haemostasis, 2024-06, Vol.22 (6), p.1715-1726

2024

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In vivo editing of lung stem cells for durable gene correction in mice

Science (American Association for the Advancement of Science), 2024-06, Vol.384 (6701), p.1196-1202

2024

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β-catenin activation is necessary and sufficient to specify the dorsal dermal fate in the mouse

Developmental biology, 2006-08, Vol.296 (1), p.164-176

2006

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Governing nonconventional genetic experimentation

Journal of law and the biosciences, 2023-01, Vol.10 (1), p.lsad003-lsad003

2023

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Notch pathway molecules are essential for the maintenance, but not the generation, of mammalian neural stem cells

Genes & development, 2002-04, Vol.16 (7), p.846-858

2002

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Reply to Lrp5 regulation of bone mass and gut serotonin synthesis

Nature medicine, 2014-11, Vol.20 (11), p.1229-1230

2014

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Notch1 is required for the coordinate segmentation of somites

Development (Cambridge), 1995-05, Vol.121 (5), p.1533-1545

1995

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The Essential Role of Cited2, a Negative Regulator for HIF-1α, in Heart Development and Neurulation

Proceedings of the National Academy of Sciences - PNAS, 2002-08, Vol.99 (16), p.10488-10493

2002

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Retinoic acid and pattern formation in vertebrates

Trends in genetics, 1995-08, Vol.11 (8), p.314-319

Conlon, Ronald A.

1995

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Oncogenic PIK3CA mutations reprogram glutamine metabolism in colorectal cancer

5-Fluorouracil Enhances the Antitumor Activity of the Glutaminase Inhibitor CB-839 against PIK3CA -Mutant Colorectal Cancers

Colorectal cancers utilize glutamine as an anaplerotic substrate of the TCA cycle in vivo

Lrp5 functions in bone to regulate bone mass

Delivering on the promise of gene editing for cystic fibrosis

A G542X cystic fibrosis mouse model for examining nonsense mutation directed therapies

Nuclear translocation of p85β promotes tumorigenesis of PIK3CA helical domain mutant cancer

An evolutionary driver of interspersed segmental duplications in primates

Huntingtin facilitates polycomb repressive complex 2

PD-L1 expression is regulated by ATP-binding of the ERBB3 pseudokinase domain

A requirement for Notch1 distinguishes 2 phases of definitive hematopoiesis during development

Axial skeletal defects caused by mutation in the spondylocostal dysplasia/pudgy gene Dll3 are associated with disruption of the segmentation clock within the presomitic mesoderm

Phenotype Variation in Two-Locus Mouse Models of Hirschsprung Disease: Tissue-Specific Interaction between Ret and Ednrb

Phosphoenolpyruvate carboxykinase and the critical role of cataplerosis in the control of hepatic metabolism

Rhodopsin mislocalization drives ciliary dysregulation in a novel autosomal dominant retinitis pigmentosa knock‐in mouse model

Suppression of proteolipid protein rescues Pelizaeus-Merzbacher disease

A mouse model of the protease-activated receptor 4 Pro310Leu variant has reduced platelet reactivity

In vivo editing of lung stem cells for durable gene correction in mice

β-catenin activation is necessary and sufficient to specify the dorsal dermal fate in the mouse

Governing nonconventional genetic experimentation

Notch pathway molecules are essential for the maintenance, but not the generation, of mammalian neural stem cells

Reply to Lrp5 regulation of bone mass and gut serotonin synthesis

Notch1 is required for the coordinate segmentation of somites

The Essential Role of Cited2, a Negative Regulator for HIF-1α, in Heart Development and Neurulation

Retinoic acid and pattern formation in vertebrates

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