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The application of positron emission tomography (PET) imaging in CNS drug development

Brain imaging and behavior, 2019-04, Vol.13 (2), p.354-365

2019

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Evaluation of 18F-RO-948 PET for Quantitative Assessment of Tau Accumulation in the Human Brain

The Journal of nuclear medicine (1978), 2018-12, Vol.59 (12), p.1877-1884

2018

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Evaluation of a semi-automated approach for FDG PET image analysis for routine clinical application in patients with multiple myeloma

Translational oncology, 2023-11, Vol.37, p.101767, Article 101767

2023

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Characterization of 3 Novel Tau Radiopharmaceuticals, 11C-RO-963, 11C-RO-643, and 18F-RO-948, in Healthy Controls and in Alzheimer Subjects

The Journal of nuclear medicine (1978), 2018-12, Vol.59 (12), p.1869-1876

2018

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Synaptic Changes in Parkinson Disease Assessed with in vivo Imaging

Annals of neurology, 2020-03, Vol.87 (3), p.329-338

2020

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A Comparison of Magnetic Resonance Imaging Methods to Assess Multiple Sclerosis Lesions: Implications for Patient Characterization and Clinical Trial Design

Diagnostics (Basel), 2021-12, Vol.12 (1), p.77

2021

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Widespread cell stress and mitochondrial dysfunction occur in patients with early Alzheimer's disease

Science translational medicine, 2022-08, Vol.14 (658), p.eabk1051

2022

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Radioligand development for molecular imaging of the central nervous system with positron emission tomography

Drug discovery today, 2014-12, Vol.19 (12), p.1936-1944

2014

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Quantification of [11C]Ro15-4513 GABAAα5 specific binding and regional selectivity in humans

Journal of cerebral blood flow and metabolism, 2017-06, Vol.37 (6), p.2137-2148

2017

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Monoamine oxidase B inhibitor, selegiline, reduces 18F-THK5351 uptake in the human brain

Alzheimer's research & therapy, 2017-03, Vol.9 (1), p.25-25, Article 25

2017

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Test–retest variability and reference region-based quantification of 18F-BCPP-EF for imaging mitochondrial complex I in the human brain

Journal of cerebral blood flow and metabolism, 2021-04, Vol.41 (4), p.771-779

2021

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Imaging Dopamine D3 Receptors in the Human Brain with Positron Emission Tomography, [11 C]PHNO, and a Selective D3 Receptor Antagonist

Biological psychiatry (1969), 2010-08, Vol.68 (4), p.392-399

2010

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Characterization of 3 PET Tracers for Quantification of Mitochondrial and Synaptic Function in Healthy Human Brain: 18 F-BCPP-EF, 11 C-SA-4503, and 11 C-UCB-J

Journal of Nuclear Medicine, 2020-01, Vol.61 (1), p.96-103

2020

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Evaluation of 18 F-RO-948 PET for Quantitative Assessment of Tau Accumulation in the Human Brain

Journal of Nuclear Medicine, 2018-12, Vol.59 (12), p.1877-1884

2018

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Support for dopaminergic hypoactivity in restless legs syndrome: a PET study on D2-receptor binding

Brain (London, England : 1878), 2006-08, Vol.129 (8), p.2017-2028

2006

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Positron emission tomography measurement of brain MAO-B inhibition in patients with Alzheimer’s disease and elderly controls after oral administration of sembragiline

European journal of nuclear medicine and molecular imaging, 2017-03, Vol.44 (3), p.382-391

2017

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Imaging in the cardiovascular and metabolic disease area

Drug discovery today, 2013-02, Vol.18 (3-4), p.185-192

2013

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Characterization of 3 PET Tracers for Quantification of Mitochondrial and Synaptic Function in Healthy Human Brain: 18F-BCPP-EF, 11C-SA-4503, and 11C-UCB-J

The Journal of nuclear medicine (1978), 2020-01, Vol.61 (1), p.96-103

2020

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Molecular imaging in oncology drug development

Drug discovery today, 2017-01, Vol.22 (1), p.140-147

2017

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[18F]BTK-1: A Novel Positron Emission Tomography Tracer for Imaging Bruton’s Tyrosine Kinase

Molecular imaging and biology, 2022-10, Vol.24 (5), p.830-841

2022

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Human Kinetic Modeling of the 5HT6 PET Radioligand 11C-GSK215083 and Its Utility for Determining Occupancy at Both 5HT6 and 5HT2A Receptors by SB742457 as a Potential Therapeutic Mechanism of Action in Alzheimer Disease

The Journal of nuclear medicine (1978), 2015-12, Vol.56 (12), p.1901-1909

2015

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Mathematical modelling of [11C]-(+)-PHNO human competition studies

NeuroImage (Orlando, Fla.), 2013-03, Vol.68, p.119-132

2013

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Characterization of 3 Novel Tau Radiopharmaceuticals, 11 C-RO-963, 11 C-RO-643, and 18 F-RO-948, in Healthy Controls and in Alzheimer Subjects

Journal of Nuclear Medicine, 2018-12, Vol.59 (12), p.1869-1876

2018

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Radiation dose estimates for carbon-11-labelled PET tracers

Nuclear medicine and biology, 2012-02, Vol.39 (2), p.305-314

2012

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Kinetic Modeling of the Tau PET Tracer 18 F-AV-1451 in Human Healthy Volunteers and Alzheimer Disease Subjects

Journal of Nuclear Medicine, 2017-07, Vol.58 (7), p.1124-1131

2017

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The application of positron emission tomography (PET) imaging in CNS drug development

Evaluation of 18F-RO-948 PET for Quantitative Assessment of Tau Accumulation in the Human Brain

Evaluation of a semi-automated approach for FDG PET image analysis for routine clinical application in patients with multiple myeloma

Characterization of 3 Novel Tau Radiopharmaceuticals, 11C-RO-963, 11C-RO-643, and 18F-RO-948, in Healthy Controls and in Alzheimer Subjects

Synaptic Changes in Parkinson Disease Assessed with in vivo Imaging

A Comparison of Magnetic Resonance Imaging Methods to Assess Multiple Sclerosis Lesions: Implications for Patient Characterization and Clinical Trial Design

Widespread cell stress and mitochondrial dysfunction occur in patients with early Alzheimer's disease

Radioligand development for molecular imaging of the central nervous system with positron emission tomography

Quantification of [11C]Ro15-4513 GABAAα5 specific binding and regional selectivity in humans

Monoamine oxidase B inhibitor, selegiline, reduces 18F-THK5351 uptake in the human brain

Test–retest variability and reference region-based quantification of 18F-BCPP-EF for imaging mitochondrial complex I in the human brain

Imaging Dopamine D3 Receptors in the Human Brain with Positron Emission Tomography, [11 C]PHNO, and a Selective D3 Receptor Antagonist

Characterization of 3 PET Tracers for Quantification of Mitochondrial and Synaptic Function in Healthy Human Brain: 18 F-BCPP-EF, 11 C-SA-4503, and 11 C-UCB-J

Evaluation of 18 F-RO-948 PET for Quantitative Assessment of Tau Accumulation in the Human Brain

Support for dopaminergic hypoactivity in restless legs syndrome: a PET study on D2-receptor binding

Positron emission tomography measurement of brain MAO-B inhibition in patients with Alzheimer’s disease and elderly controls after oral administration of sembragiline

Imaging in the cardiovascular and metabolic disease area

Characterization of 3 PET Tracers for Quantification of Mitochondrial and Synaptic Function in Healthy Human Brain: 18F-BCPP-EF, 11C-SA-4503, and 11C-UCB-J

Molecular imaging in oncology drug development

[18F]BTK-1: A Novel Positron Emission Tomography Tracer for Imaging Bruton’s Tyrosine Kinase

Human Kinetic Modeling of the 5HT6 PET Radioligand 11C-GSK215083 and Its Utility for Determining Occupancy at Both 5HT6 and 5HT2A Receptors by SB742457 as a Potential Therapeutic Mechanism of Action in Alzheimer Disease

Mathematical modelling of [11C]-(+)-PHNO human competition studies

Characterization of 3 Novel Tau Radiopharmaceuticals, 11 C-RO-963, 11 C-RO-643, and 18 F-RO-948, in Healthy Controls and in Alzheimer Subjects

Radiation dose estimates for carbon-11-labelled PET tracers

Kinetic Modeling of the Tau PET Tracer 18 F-AV-1451 in Human Healthy Volunteers and Alzheimer Disease Subjects

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