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Measurement and meaning of cellular thiol:disufhide redox status

Free radical research, 2016-02, Vol.50 (2), p.246-271

Comini, Marcelo A.

2016

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Drugging the Undruggable Trypanosoma brucei Monothiol Glutaredoxin 1

Molecules (Basel, Switzerland), 2023-01, Vol.28 (3), p.1276

2023

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Generation and Characterization of Stable Redox-Reporter Mammalian Cell Lines of Biotechnological Relevance

Sensors (Basel, Switzerland), 2022-02, Vol.22 (4), p.1324

2022

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The indole motif is essential for the antitrypanosomal activity of N5-substituted paullones

PloS one, 2023-11, Vol.18 (11), p.e0292946-e0292946

2023

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Glucose 6-Phosphate Dehydrogenase from Trypanosomes: Selectivity for Steroids and Chemical Validation in Bloodstream Trypanosoma brucei

Molecules (Basel, Switzerland), 2021-01, Vol.26 (2), p.358

2021

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Drug-like molecules with anti-trypanothione synthetase activity identified by high throughput screening

Journal of enzyme inhibition and medicinal chemistry, 2022-12, Vol.37 (1), p.912-929

2022

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Murine colon organoids as a novel model to study Trypanosoma cruzi infection and interactions with the intestinal epithelium

Frontiers in cellular and infection microbiology, 2023-03, Vol.13, p.1082524-1082524

2023

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Identification of Novel Chemical Scaffolds Inhibiting Trypanothione Synthetase from Pathogenic Trypanosomatids

PLoS neglected tropical diseases, 2016-04, Vol.10 (4), p.e0004617-e0004617

2016

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An essential thioredoxin-type protein of Trypanosoma brucei acts as redox-regulated mitochondrial chaperone

PLoS pathogens, 2019-09, Vol.15 (9), p.e1008065-e1008065

2019

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Binding Mode and Selectivity of Steroids towards Glucose-6-phosphate Dehydrogenase from the Pathogen Trypanosoma cruzi

Molecules (Basel, Switzerland), 2016-03, Vol.21 (3), p.368

2016

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Selenosugars targeting the infective stage of Trypanosoma brucei with high selectivity

International journal for parasitology -- drugs and drug resistance, 2024-04, Vol.24, p.100529-100529, Article 100529

2024

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Nox2-derived superoxide radical is crucial to control acute Trypanosoma cruzi infection

Redox biology, 2021-10, Vol.46, p.102085-102085, Article 102085

2021

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Expression and functional characterization of chimeric recombinant bovine follicle‐stimulating hormone produced in Leishmania tarentolae

Microbial biotechnology, 2024-04, Vol.17 (4), p.e14444-n/a

2024

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The lineage-specific, intrinsically disordered N-terminal extension of monothiol glutaredoxin 1 from trypanosomes contains a regulatory region

Scientific reports, 2018-09, Vol.8 (1), p.13716-14, Article 13716

2018

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Depletion of the thioredoxin homologue tryparedoxin impairs antioxidative defence in African trypanosomes

Biochemical journal, 2007-02, Vol.402 (1), p.43-49

2007

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Diglycosyl diselenides alter redox homeostasis and glucose consumption of infective African trypanosomes

International journal for parasitology -- drugs and drug resistance, 2017-12, Vol.7 (3), p.303-313

2017

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Cytosolic peroxidases protect the lysosome of bloodstream African trypanosomes from iron-mediated membrane damage

PLoS pathogens, 2014-04, Vol.10 (4), p.e1004075-e1004075

2014

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Mechanistic and biological characterisation of novel N5-substituted paullones targeting the biosynthesis of trypanothione in Leishmania

Journal of enzyme inhibition and medicinal chemistry, 2020-12, Vol.35 (1), p.1345-1358

2020

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A glutaredoxin in the mitochondrial intermembrane space has stage-specific functions in the thermo-tolerance and proliferation of African trypanosomes

Redox biology, 2018-05, Vol.15 (C), p.532-547

2018

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Evaluation of the Anti- Leishmania mexicana and - Trypanosoma brucei Activity and Mode of Action of 4,4'-(Arylmethylene)bis(3-methyl-1-phenyl-1 H -pyrazol-5-ol)

Biomedicines, 2022-08, Vol.10 (8), p.1913

2022

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Novel distamycin analogues that block the cell cycle of African trypanosomes with high selectivity and potency

European journal of medicinal chemistry, 2020-03, Vol.189, p.112043, Article 112043

2020

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Redox control in trypanosomatids, parasitic protozoa with trypanothione-based thiol metabolism

Biochimica et biophysica acta, 2008-11, Vol.1780 (11), p.1236-1248

2008

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CUTie2: The Attack of the Cyclic Nucleotide Sensor Clones

Frontiers in molecular biosciences, 2021-03, Vol.8, p.629773-629773

2021

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The Redox Activity of Protein Disulfide Isomerase Inhibits ALS Phenotypes in Cellular and Zebrafish Models

iScience, 2020-05, Vol.23 (5), p.101097-101097, Article 101097

2020

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Monothiol Glutaredoxin-1 Is an Essential Iron-Sulfur Protein in the Mitochondrion of African Trypanosomes

The Journal of biological chemistry, 2008-10, Vol.283 (41), p.27785-27798

2008

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Measurement and meaning of cellular thiol:disufhide redox status

Drugging the Undruggable Trypanosoma brucei Monothiol Glutaredoxin 1

Generation and Characterization of Stable Redox-Reporter Mammalian Cell Lines of Biotechnological Relevance

The indole motif is essential for the antitrypanosomal activity of N5-substituted paullones

Glucose 6-Phosphate Dehydrogenase from Trypanosomes: Selectivity for Steroids and Chemical Validation in Bloodstream Trypanosoma brucei

Drug-like molecules with anti-trypanothione synthetase activity identified by high throughput screening

Murine colon organoids as a novel model to study Trypanosoma cruzi infection and interactions with the intestinal epithelium

Identification of Novel Chemical Scaffolds Inhibiting Trypanothione Synthetase from Pathogenic Trypanosomatids

An essential thioredoxin-type protein of Trypanosoma brucei acts as redox-regulated mitochondrial chaperone

Binding Mode and Selectivity of Steroids towards Glucose-6-phosphate Dehydrogenase from the Pathogen Trypanosoma cruzi

Selenosugars targeting the infective stage of Trypanosoma brucei with high selectivity

Nox2-derived superoxide radical is crucial to control acute Trypanosoma cruzi infection

Expression and functional characterization of chimeric recombinant bovine follicle‐stimulating hormone produced in Leishmania tarentolae

The lineage-specific, intrinsically disordered N-terminal extension of monothiol glutaredoxin 1 from trypanosomes contains a regulatory region

Depletion of the thioredoxin homologue tryparedoxin impairs antioxidative defence in African trypanosomes

Diglycosyl diselenides alter redox homeostasis and glucose consumption of infective African trypanosomes

Cytosolic peroxidases protect the lysosome of bloodstream African trypanosomes from iron-mediated membrane damage

Mechanistic and biological characterisation of novel N5-substituted paullones targeting the biosynthesis of trypanothione in Leishmania

A glutaredoxin in the mitochondrial intermembrane space has stage-specific functions in the thermo-tolerance and proliferation of African trypanosomes

Evaluation of the Anti- Leishmania mexicana and - Trypanosoma brucei Activity and Mode of Action of 4,4'-(Arylmethylene)bis(3-methyl-1-phenyl-1 H -pyrazol-5-ol)

Novel distamycin analogues that block the cell cycle of African trypanosomes with high selectivity and potency

Redox control in trypanosomatids, parasitic protozoa with trypanothione-based thiol metabolism

CUTie2: The Attack of the Cyclic Nucleotide Sensor Clones

The Redox Activity of Protein Disulfide Isomerase Inhibits ALS Phenotypes in Cellular and Zebrafish Models

Monothiol Glutaredoxin-1 Is an Essential Iron-Sulfur Protein in the Mitochondrion of African Trypanosomes

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