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Measurement and meaning of cellular thiol:disufhide redox status

Free radical research, 2016-02, Vol.50 (2), p.246-271

Comini, Marcelo A.

2016

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The Thiol-polyamine Metabolism of Trypanosoma cruzi: Molecular Targets and Drug Repurposing Strategies

Current medicinal chemistry, 2019-01, Vol.26 (36), p.6614

2019

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Glucose-6-Phosphate Dehydrogenase from the Human Pathogen Trypanosoma cruzi Evolved Unique Structural Features to Support Efficient Product Formation

Journal of molecular biology, 2019-05, Vol.431 (11), p.2143-2162

2019

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Drugging the Undruggable Trypanosoma brucei Monothiol Glutaredoxin 1

Molecules (Basel, Switzerland), 2023-01, Vol.28 (3), p.1276

2023

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Novel distamycin analogues that block the cell cycle of African trypanosomes with high selectivity and potency

European journal of medicinal chemistry, 2020-03, Vol.189, p.112043, Article 112043

2020

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Redox control in trypanosomatids, parasitic protozoa with trypanothione-based thiol metabolism

Biochimica et biophysica acta, 2008-11, Vol.1780 (11), p.1236-1248

2008

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A simple, robust, and affordable bioluminescent assay for drug discovery against infective African trypanosomes

Drug development research, 2022-04, Vol.83 (2), p.253-263

2022

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Generation and Characterization of Stable Redox-Reporter Mammalian Cell Lines of Biotechnological Relevance

Sensors (Basel, Switzerland), 2022-02, Vol.22 (4), p.1324

2022

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Organocatalytic Synthesis and Anti‐Trypanosomal Activity Evaluation of L‐Pentofuranose‐Mimetic Iminosugars

European journal of organic chemistry, 2022-09, Vol.2022 (34), p.n/a

2022

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Discovery of novel Leishmania major trypanothione synthetase inhibitors by high-throughput screening

Biochemical and biophysical research communications, 2022-12, Vol.637, p.308-313

2022

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The indole motif is essential for the antitrypanosomal activity of N5-substituted paullones

PloS one, 2023-11, Vol.18 (11), p.e0292946-e0292946

2023

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Glucose 6-Phosphate Dehydrogenase from Trypanosomes: Selectivity for Steroids and Chemical Validation in Bloodstream Trypanosoma brucei

Molecules (Basel, Switzerland), 2021-01, Vol.26 (2), p.358

2021

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An essential thioredoxin-type protein of Trypanosoma brucei acts as redox-regulated mitochondrial chaperone

PLoS pathogens, 2019-09, Vol.15 (9), p.e1008065-e1008065

2019

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Binding Mode and Selectivity of Steroids towards Glucose-6-phosphate Dehydrogenase from the Pathogen Trypanosoma cruzi

Molecules (Basel, Switzerland), 2016-03, Vol.21 (3), p.368

2016

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Identification of Novel Chemical Scaffolds Inhibiting Trypanothione Synthetase from Pathogenic Trypanosomatids

PLoS neglected tropical diseases, 2016-04, Vol.10 (4), p.e0004617-e0004617

2016

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Drug-like molecules with anti-trypanothione synthetase activity identified by high throughput screening

Journal of enzyme inhibition and medicinal chemistry, 2022-12, Vol.37 (1), p.912-929

2022

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Depletion of the thioredoxin homologue tryparedoxin impairs antioxidative defence in African trypanosomes

Biochemical journal, 2007-02, Vol.402 (1), p.43-49

2007

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Murine colon organoids as a novel model to study Trypanosoma cruzi infection and interactions with the intestinal epithelium

Frontiers in cellular and infection microbiology, 2023-03, Vol.13, p.1082524-1082524

2023

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Mono- and dithiol glutaredoxins in the trypanothione-based redox metabolism of pathogenic trypanosomes

Antioxidants & redox signaling, 2013-09, Vol.19 (7), p.708

2013

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Cytosolic peroxidases protect the lysosome of bloodstream African trypanosomes from iron-mediated membrane damage

PLoS pathogens, 2014-04, Vol.10 (4), p.e1004075-e1004075

2014

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In vitro activity and mode of action of distamycin analogues against African trypanosomes

European journal of medicinal chemistry, 2017-01, Vol.126, p.776-788

2017

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Determination of acidity and nucleophilicity in thiols by reaction with monobromobimane and fluorescence detection

Analytical biochemistry, 2013-04, Vol.435 (1), p.74-82

2013

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Kinetic studies reveal a key role of a redox-active glutaredoxin in the evolution of the thiol-redox metabolism of trypanosomatid parasites

The Journal of biological chemistry, 2019-03, Vol.294 (9), p.3235-3248

2019

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Mode of action of p-quinone derivatives with trypanocidal activity studied by experimental and in silico models

European journal of medicinal chemistry, 2023-01, Vol.246, p.114926-114926, Article 114926

2023

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Selenosugars targeting the infective stage of Trypanosoma brucei with high selectivity

International journal for parasitology -- drugs and drug resistance, 2024-04, Vol.24, p.100529-100529, Article 100529

2024

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Measurement and meaning of cellular thiol:disufhide redox status

The Thiol-polyamine Metabolism of Trypanosoma cruzi: Molecular Targets and Drug Repurposing Strategies

Glucose-6-Phosphate Dehydrogenase from the Human Pathogen Trypanosoma cruzi Evolved Unique Structural Features to Support Efficient Product Formation

Drugging the Undruggable Trypanosoma brucei Monothiol Glutaredoxin 1

Novel distamycin analogues that block the cell cycle of African trypanosomes with high selectivity and potency

Redox control in trypanosomatids, parasitic protozoa with trypanothione-based thiol metabolism

A simple, robust, and affordable bioluminescent assay for drug discovery against infective African trypanosomes

Generation and Characterization of Stable Redox-Reporter Mammalian Cell Lines of Biotechnological Relevance

Organocatalytic Synthesis and Anti‐Trypanosomal Activity Evaluation of L‐Pentofuranose‐Mimetic Iminosugars

Discovery of novel Leishmania major trypanothione synthetase inhibitors by high-throughput screening

The indole motif is essential for the antitrypanosomal activity of N5-substituted paullones

Glucose 6-Phosphate Dehydrogenase from Trypanosomes: Selectivity for Steroids and Chemical Validation in Bloodstream Trypanosoma brucei

An essential thioredoxin-type protein of Trypanosoma brucei acts as redox-regulated mitochondrial chaperone

Binding Mode and Selectivity of Steroids towards Glucose-6-phosphate Dehydrogenase from the Pathogen Trypanosoma cruzi

Identification of Novel Chemical Scaffolds Inhibiting Trypanothione Synthetase from Pathogenic Trypanosomatids

Drug-like molecules with anti-trypanothione synthetase activity identified by high throughput screening

Depletion of the thioredoxin homologue tryparedoxin impairs antioxidative defence in African trypanosomes

Murine colon organoids as a novel model to study Trypanosoma cruzi infection and interactions with the intestinal epithelium

Mono- and dithiol glutaredoxins in the trypanothione-based redox metabolism of pathogenic trypanosomes

Cytosolic peroxidases protect the lysosome of bloodstream African trypanosomes from iron-mediated membrane damage

In vitro activity and mode of action of distamycin analogues against African trypanosomes

Determination of acidity and nucleophilicity in thiols by reaction with monobromobimane and fluorescence detection

Kinetic studies reveal a key role of a redox-active glutaredoxin in the evolution of the thiol-redox metabolism of trypanosomatid parasites

Mode of action of p-quinone derivatives with trypanocidal activity studied by experimental and in silico models

Selenosugars targeting the infective stage of Trypanosoma brucei with high selectivity

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