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Design, Synthesis, and Characterization of Novel sn-1 Heterocyclic DAG-Lactones as PKC Activators

Journal of medicinal chemistry, 2021-08, Vol.64 (15), p.11418-11431

2021

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Exploring the influence of indololactone structure on selectivity for binding to the C1 domains of PKCα, PKCε, and RasGRP

Bioorganic & medicinal chemistry, 2017-06, Vol.25 (12), p.2971-2980

2017

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New progresses in the enantioselective synthesis and biological properties of carbocyclic nucleosides

Mini reviews in medicinal chemistry, 2003-03, Vol.3 (2), p.95-114

2003

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Preclinical development of novel Rac1-GEF signaling inhibitors using a rational design approach in highly aggressive breast cancer cell lines

Anti-cancer agents in medicinal chemistry, 2014-01, Vol.14 (6), p.840-851

2014

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Synthesis, biological, and biophysical studies of DAG-indololactones designed as selective activators of RasGRP

Bioorganic & medicinal chemistry, 2014-06, Vol.22 (12), p.3123-3140

2014

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New human papilloma virus E2 transcription factor mimics: a tripyrrole-peptide conjugate with tight and specific DNA-recognition

PloS one, 2011-07, Vol.6 (7), p.e22409

2011

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Cerium ammonium nitrate: a new catalyst for regioselective protection of glycols

Tetrahedron, 2004-12, Vol.60 (51), p.11851-11860

2004

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Synthesis of Conformationally Locked Carbocyclic Nucleosides Built on a Thiabicyclo[3.1.0]hexane System as a Pseudosugar Surrogate

European Journal of Organic Chemistry, 2006-10, Vol.2006 (19), p.4473-4482

2006

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Synthesis of Bicyclo[3.1.0]hexanes Functionalized at the Tip of the Cyclopropane Ring. Application to the Synthesis of Carbocyclic Nucleosides

Organic letters, 2006-02, Vol.8 (4), p.705-708

2006

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Development of an Improved Guanidine‐Based Rac1 Inhibitor with in vivo Activity against Non‐Small Cell Lung Cancer

ChemMedChem, 2021-03, Vol.16 (6), p.1011-1021

2021

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Sculpting the Bicyclo[3.1.0]hexane Template of Carbocyclic Nucleosides to Improve Recognition by Herpes Thymidine Kinase

Journal of the American Chemical Society, 2007-05, Vol.129 (19), p.6216-6222

2007

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Anti-Selective Organocatalytic Michael Addition between Phenylacetaldehyde and Nitrostyrene

Journal of organic chemistry, 2016-09, Vol.81 (17), p.7952-7957

2016

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D-(+)-iso-Methanocarbathymidine: a High-Affinity Substrate for Herpes Simplex Virus 1 Thymidine Kinase

ChemMedChem, 2008-07, Vol.3 (7), p.1129-1134

2008

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Synthesis and characterization of new related substances of the antiarrhythmic drug dronedarone hydrochloride

Journal of pharmaceutical and biomedical analysis, 2015-10, Vol.114, p.441-446

2015

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Synthetic studies toward the preparation of (4 R,5 R)-(−)-3-[(benzyloxy)methyl]-4,5- O-isopropylidene-cyclopenten-2-one: an important synthetic intermediate for carbanucleosides

Tetrahedron: asymmetry, 2005-01, Vol.16 (2), p.425-431

2005

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Synthesis of conformationally locked carbocyclic nucleosides built on an oxabicyclo[3.1.0]hexane system

Tetrahedron, 2003-01, Vol.59 (3), p.295-301

2003

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Enantioselective synthesis of (+)-neplanocin F

Tetrahedron, 2002-04, Vol.58 (16), p.3129-3136

2002

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First total synthesis of (+)-neplanocin B

ARKIVOC, 2005-12, Vol.2005 (12), p.205-213

2005

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Evaluation of the antiviral activity of natural sulfated polyhydroxysteroids and their synthetic derivatives and analogs

Steroids, 1999-05, Vol.64 (5), p.335-340

1999

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Membrane anchoring of diacylglycerol lactones substituted with rigid hydrophobic acyl domains correlates with biological activities

The FEBS journal, 2010-01, Vol.277 (1), p.233-243

2010

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A Conformationally Locked Analogue of the Anti-HIV Agent Stavudine. An Important Correlation between Pseudorotation and Maximum Amplitude

Journal of medicinal chemistry, 2003-07, Vol.46 (15), p.3292-3299

2003

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Self-Assembly and Lipid Interactions of Diacylglycerol Lactone Derivatives Studied at the Air/Water Interface

Langmuir, 2008-10, Vol.24 (19), p.11043-11052

2008

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Conformationally Constrained Analogues of Diacylglycerol (DAG). 31. Modulation of the Biological Properties of Diacylgycerol Lactones (DAG-lactones) Containing Rigid-Rod Acyl Groups Separated from the Core Lactone by Spacer Units of Different Lengths

Journal of medicinal chemistry, 2009-05, Vol.52 (10), p.3274-3283

2009

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Structural determinants of efficacy at A3 adenosine receptors: modification of the ribose moiety

Biochemical pharmacology, 2004-03, Vol.67 (5), p.893-901

2004

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Rho GTPases as therapeutic targets in cancer and other human diseases

Medicina (Buenos Aires), 2010, Vol.70 (6), p.555-564

2010

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Design, Synthesis, and Characterization of Novel sn-1 Heterocyclic DAG-Lactones as PKC Activators

Exploring the influence of indololactone structure on selectivity for binding to the C1 domains of PKCα, PKCε, and RasGRP

New progresses in the enantioselective synthesis and biological properties of carbocyclic nucleosides

Preclinical development of novel Rac1-GEF signaling inhibitors using a rational design approach in highly aggressive breast cancer cell lines

Synthesis, biological, and biophysical studies of DAG-indololactones designed as selective activators of RasGRP

New human papilloma virus E2 transcription factor mimics: a tripyrrole-peptide conjugate with tight and specific DNA-recognition

Cerium ammonium nitrate: a new catalyst for regioselective protection of glycols

Synthesis of Conformationally Locked Carbocyclic Nucleosides Built on a Thiabicyclo[3.1.0]hexane System as a Pseudosugar Surrogate

Synthesis of Bicyclo[3.1.0]hexanes Functionalized at the Tip of the Cyclopropane Ring. Application to the Synthesis of Carbocyclic Nucleosides

Development of an Improved Guanidine‐Based Rac1 Inhibitor with in vivo Activity against Non‐Small Cell Lung Cancer

Sculpting the Bicyclo[3.1.0]hexane Template of Carbocyclic Nucleosides to Improve Recognition by Herpes Thymidine Kinase

Anti-Selective Organocatalytic Michael Addition between Phenylacetaldehyde and Nitrostyrene

D-(+)-iso-Methanocarbathymidine: a High-Affinity Substrate for Herpes Simplex Virus 1 Thymidine Kinase

Synthesis and characterization of new related substances of the antiarrhythmic drug dronedarone hydrochloride

Synthetic studies toward the preparation of (4 R,5 R)-(−)-3-[(benzyloxy)methyl]-4,5- O-isopropylidene-cyclopenten-2-one: an important synthetic intermediate for carbanucleosides

Synthesis of conformationally locked carbocyclic nucleosides built on an oxabicyclo[3.1.0]hexane system

Enantioselective synthesis of (+)-neplanocin F

First total synthesis of (+)-neplanocin B

Evaluation of the antiviral activity of natural sulfated polyhydroxysteroids and their synthetic derivatives and analogs

Membrane anchoring of diacylglycerol lactones substituted with rigid hydrophobic acyl domains correlates with biological activities

A Conformationally Locked Analogue of the Anti-HIV Agent Stavudine. An Important Correlation between Pseudorotation and Maximum Amplitude

Self-Assembly and Lipid Interactions of Diacylglycerol Lactone Derivatives Studied at the Air/Water Interface

Conformationally Constrained Analogues of Diacylglycerol (DAG). 31. Modulation of the Biological Properties of Diacylgycerol Lactones (DAG-lactones) Containing Rigid-Rod Acyl Groups Separated from the Core Lactone by Spacer Units of Different Lengths

Structural determinants of efficacy at A3 adenosine receptors: modification of the ribose moiety

Rho GTPases as therapeutic targets in cancer and other human diseases

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